Ibufen D

The drug Ibufen D is a non-steroidal anti-inflammatory drug, which also has analgesic and antipyretic effects. Refers to drugs containing the propionic acid derivative ibuprofen. Among its synonyms: Ibuprofen, Ibuprof, Ibufen Junior, Nurofen, etc.

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Indications Ibufen D

The list of indications for the use of this drug in the treatment of children includes: acute respiratory viral infections, as well as any childhood infections with an increase in body temperature; pain and inflammation of the throat (tonsillitis, pharyngitis), middle ear (otitis); headache, toothache, muscle and joint pain; pain during teething; conditions caused by vaccination: pain and swelling with bruises and sprains of the ligaments of the musculoskeletal system.

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Release form

Ibufen D - suspensions for internal use (in 120 ml bottles) with a dosing spoon or dosing syringe. 5 ml of suspension contains 100 mg of ibuprofen, as well as such excipients as macrogol, glyceryl hydroxystearate, xanthan gum, glycerol, sodium benzoate, citric acid monohydrate, sodium saccharinate, liquid maltitol, orange flavoring, purified water.

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Pharmacodynamics

Pharmacodynamics of Ibufen D is provided by the active substance of the drug ibuprofen, which blocks the enzyme cyclooxygenase (COX) - a catalyst for the reaction of converting arachidonic acid into neurohumoral mediators of inflammatory reactions of the body prostaglandins. Due to the decrease in the activity of synthesis of neurotransmitters, a response reaction of the proteolytic kallikrein-kinin system of the body occurs, which takes part in the regulation and development of pathological conditions associated with pain syndrome, inflammation and increased synthesis of endogenous pyrogens with an increase in temperature. A decrease in the conduction of pain signals gives an analgesic, anti-inflammatory and antipyretic effect of Ibufen D.

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Pharmacokinetics

After oral administration, the active substance Ibufen D (ibuprofen) is absorbed in the gastrointestinal tract; 90% of the substance binds to plasma proteins, reaching maximum concentration after 45-90 minutes; penetrates into the synovial fluid, where the highest concentration is reached after approximately 2-3 hours, which leads to a decrease in body temperature to normal values.

Presystemic and postsystemic metabolism of Ibufen D occurs in the liver; transformation products and partially unchanged ibuprofen (no more than 1%) are eliminated by the kidneys - with urine - and in small quantities by bile (with feces). The drug does not accumulate in the body; half of the drug taken is excreted in 2-2.5 hours, complete excretion occurs within 24 hours.

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Dosing and administration

Ibufen D should be taken orally - after meals, with water. The dose is determined by the doctor individually and depends on the nature of the disease, the child's age and body weight.

The standard dosage for children aged 3-12 months (weight 5 to 9 kg) is 50 mg 3 times a day; for children aged 1 to 3 years (weight 10 to 15 kg) - 100 mg (three times a day); for children aged 4-6 years (weight 16 to 20 kg) - 150 mg; for children aged 7-9 years (weight up to 30 kg) - 200 mg; for children aged 10-12 years (weight 30 to 40 kg) - 300 mg 3 times a day. The maximum duration of treatment for fever is three days, and for pain syndrome - five days.

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Use Ibufen D during pregnancy

Use during pregnancy in the first and second trimesters is not recommended due to the lack of reliable data on its safety for the mother and fetus. Use of this drug in the last three months of pregnancy is contraindicated.

Contraindications

Contraindications to the use of Ibufen D are:

• individual hypersensitivity to the components of the drug (ibuprofen) and non-steroidal anti-inflammatory drugs (NSAIDs);
• history of allergic reaction to acetylsalicylic acid;
• exacerbation of gastric ulcer and duodenal ulcer, ulcerative colitis, Crohn's disease;
• severe liver and/or kidney dysfunction;
• decreased blood clotting (hemophilia, hemorrhagic diathesis);
• last trimester of pregnancy;
• children under 3 months of age.

Use during pregnancy in the first and second trimesters is not recommended due to the lack of reliable data on its safety for the mother and fetus. Use of this drug in the last three months of pregnancy is contraindicated.

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Side effects Ibufen D

The main possible side effects of Ibuprofen D are expressed as:

• headache, dizziness, drowsiness;
• feelings of discomfort and pain in the stomach, nausea, vomiting and loss of appetite;
• allergic reactions (skin rash, itching, bronchospasm, asthma attacks);
• anemia, thrombocytopenia or leukopenia.

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Overdose

Overdose of Ibuprofen D leads to symptoms such as headache, nausea, vomiting, abdominal pain, tinnitus, acute renal failure, decreased heart rate.

Treatment of overdose is carried out by gastric lavage and alkaline drink.

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Interactions with other drugs

Ibuprofen D should not be taken simultaneously with other non-steroidal anti-inflammatory drugs and acetylsalicylic acid.

Ibuprofen D reduces the effectiveness of drugs used for hypertension, as well as diuretics.

Ibuprofen D enhances the effect of anticoagulants and increases the risk of side effects of corticosteroids.

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Storage conditions

Storage conditions for Ibuprofen D: at a temperature of +20-25°C.

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Shelf life

Shelf life is 3 years, unopened bottle – 6 months.

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