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Health

Ibufen D

, medical expert
Last reviewed: 23.04.2024
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The drug Ibufen D is a non-steroidal anti-inflammatory drug, which also has analgesic and antipyretic effects. Refers to preparations containing a derivative of propionic acid ibuprofen. Among its synonyms: Ibuprofen, Ibuprof, Ibufen junior, Nurofen, etc.

trusted-source[1]

Indications Ibufen D

The list of indications for the use of this drug in the treatment of children includes: acute respiratory viral infections, as well as any childhood infections with fever; pain and inflammation of the throat (sore throat, pharyngitis), middle ear (otitis); headache, dental, muscular and joint pain; soreness with teething; conditions caused by vaccination: pain and swelling with bruises and sprains of the ligaments of the musculoskeletal system.

trusted-source[2], [3], [4]

Release form

Ibufen D - suspensions for internal use (in bottles of 120 ml) with a spoon-dispenser or syringe-dispenser. 5 ml of the suspension contains 100 mg of ibuprofen, as well as auxiliary substances such as macrogol, glyceryl hydroxy stearate, xanthan gum, glycerol, sodium benzoate, citric acid monohydrate, sodium saccharinate, liquid maltitol, orange flavor, purified water.

trusted-source[5], [6], [7]

Pharmacodynamics

Pharmacodynamics Ibufen D is provided by the active substance of the drug ibuprofen, which blocks the enzyme cyclooxygenase (COX) - a catalyst for the reaction of the conversion of arachidonic acid into neurohumoral mediators of inflammatory reactions of the prostaglandin organism. Due to the decrease in the activity of synthesis of neurotransmitters, the response of the proteolytic kallikrein-kinin system of the organism takes place, which takes part in the regulation and development of pathological conditions associated with pain syndrome, inflammation and increased synthesis of endogenous pyrogens as the temperature rises. Reduction of pain signals gives an analgesic, anti-inflammatory and antipyretic effect. Ibufen D.

trusted-source[8], [9], [10], [11], [12], [13], [14], [15]

Pharmacokinetics

After ingestion, the active ingredient Ibufen D (ibuprofen) is absorbed into the digestive tract; 90% of the substance binds to blood plasma proteins, reaching a maximum concentration after 45-90 minutes; penetrates into the synovial fluid, where the highest concentration is reached after about 2-3 hours, which leads to a decrease in body temperature to normal levels.

Pre-systemic and post-systemic metabolism of Ibufen D occurs in the liver; the products of transformation and partially unchanged ibuprofen (not more than 1%) are eliminated by the kidneys - with urine - and in minor amounts with bile (with feces). The drug does not accumulate in the body; half of the drug taken is withdrawn after 2-2.5 hours, complete elimination occurs within 24 hours.

trusted-source[16], [17], [18], [19]

Dosing and administration

Ibuphen D should be taken orally - after eating, with water. The dose is determined by the doctor individually and depends on the nature of the disease, the age of the child and the weight of his body.

Standard dosage for children 3-12 months (body weight from 5 to 9 kg) - 50 mg 3 times a day; for children from 1 year to 3 years (with a body weight of 10-15 kg) - 100 mg (three times a day); for children 4-6 years (body weight 16-20 kg) - 150 mg; for children 7-9 years old (body weight up to 30 kg) - 200 mg; for children 10-12 years old (body weight from 30 to 40 kg) - 300 mg 3 times a day. The maximum duration of treatment at elevated temperature is three days, with pain syndrome - five days.

trusted-source[26], [27], [28], [29], [30], [31], [32]

Use Ibufen D during pregnancy

Use during pregnancy in the first and second trimesters is not recommended because of the lack of reliable data on its safety for the mother and fetus. The use of this drug in the last three months of pregnancy is contraindicated.

Contraindications

Contraindications to the use of Ibufen D are:

  • individual hypersensitivity to the drug components (ibuprofen) and non-steroidal anti-inflammatory drugs (NSAIDs);
  • an allergic reaction to acetylsalicylic acid in the anamnesis;
  • exacerbation of peptic ulcer of stomach and duodenum, ulcerative colitis, Crohn's disease;
  • severe liver and / or kidney dysfunction;
  • reduced blood clotting (hemophilia, hemorrhagic diathesis);
  • the last trimester of pregnancy;
  • Children's age is up to 3 months.

Use during pregnancy in the first and second trimesters is not recommended because of the lack of reliable data on its safety for the mother and fetus. The use of this drug in the last three months of pregnancy is contraindicated.

trusted-source[20], [21], [22], [23]

Side effects Ibufen D

The main possible side effects of Ibufen D are expressed as:

  • headache, dizziness, drowsiness;
  • feelings of discomfort and pain in the stomach, nausea, vomiting and decreased appetite;
  • allergic reactions (skin rash, itching, spasm of bronchial tubes, attacks of suffocation);
  • anemia, thrombocytopenia or leukopenia.

trusted-source[24], [25]

Overdose

An overdose of Ibufen D leads to symptoms such as headache, nausea, vomiting, abdominal pain, tinnitus, acute renal failure, and a decrease in heart rate.

Treatment of overdose is carried out by washing the stomach and alkaline drink. 

trusted-source[33], [34], [35], [36]

Interactions with other drugs

Do not take Ibufen D simultaneously with other nonsteroidal anti-inflammatory drugs and acetylsalicylic acid.

Ibuphen D causes a decrease in the effectiveness of drugs used in hypertension, as well as diuretics.

Ibufen D enhances the effect of anticoagulants and increases the threat of side effects of corticosteroids.

trusted-source[37], [38], [39],

Storage conditions

Conditions of storage of Ibufen D - at a temperature of + 20-25 ° C.

trusted-source[40], [41]

Shelf life

Shelf life - 3 years, printed vial - 6 months.

trusted-source[42]

Attention!

To simplify the perception of information, this instruction for use of the drug "Ibufen D" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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