Heparil

Heparil has an intense anticoagulant and antithrombotic effect, demonstrates anti-edematous activity, reduces inflammation and helps heal connective tissues.

The anticoagulant effect develops with a direct effect on the blood coagulation system, by forming a compound with antithrombin-3, which synthesizes intraplasmic coagulation factors. The substance stimulates metabolism, tissue epithelialization and granulation. The intensity of the medicinal effect of the gel significantly exceeds the effect of ointments - because the gel can penetrate deeper into the tissues.

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Indications Heparil

It is used for diseases affecting superficial veins, such as varicose veins (and its complications), thrombophlebitis with phlebothrombosis, and superficial periphlebitis.

Can be used for postoperative varicose phlebitis and complications associated with surgical removal of subcutaneous veins in the legs.

It is prescribed in case of localized swelling, infiltrates, bruises with injuries, and subcutaneous hematomas. Together with this, it is used in case of sprains or injuries affecting the capsule-ligament and muscle-tendon structures.

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Release form

The medicinal component is released in the form of a gel, inside tubes with a capacity of 40 g. There is 1 tube in a box.

Pharmacokinetics

Heparin is determined in blood plasma for 24 hours from the moment of using the drug; Cmax heparin values are noted after 8 hours. After external treatment, the gel does not cause the development of systemic effects.

After absorption of the substance, it undergoes intrahepatic and reticuloendothelial biotransformation. Intraplasmic protein synthesis is 95%.

The half-life is 1-1.5 hours. Excretion is via the kidneys.

Dosing and administration

The medicine is used 1-3 times a day. The affected area is treated with gel (3-10 cm), gently rubbing it in. The duration of therapy is selected individually (this is done by the attending physician), taking into account the intensity of the pathology.

The applied substance is completely absorbed through the epidermis after 1.5-2 minutes, leaving no stains.

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Use Heparil during pregnancy

There is no information regarding the use of the drug during lactation or pregnancy, so it is not prescribed during these periods.

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Contraindications

Among the contraindications:

• severe intolerance to heparin or other components of the drug, including parabens (nipasol with nipagin);
• bleeding trophic ulcers on the legs;
• infected or open wounds;
• hemophilia;
• hemorrhagic diathesis;
• thrombocytopenia or purpura;
• tendency to bleeding.

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Side effects Heparil

Sometimes intolerance manifestations may be observed, including epidermal itching and swelling, burning, redness, urticaria, hemorrhages, rashes and Quincke's edema. In addition, the appearance of small bubbles, pustules or blisters is possible (they quickly disappear after stopping the use of the drug). Treatment of large areas of the epidermis can cause general side effects.

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Overdose

If a small child accidentally swallows the gel, vomiting or nausea may occur.

If this occurs, gastric lavage and symptomatic measures should be performed if necessary. The effect of heparin is neutralized with protamine sulfate.

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Interactions with other drugs

Heparin helps prolong PT values in people using oral anticoagulants.

It is prohibited to combine Heparil with other local medications (for example, substances containing salicylic acid, tetracycline or hydrocortisone) and anticoagulants.

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Storage conditions

Heparil should be stored in a place closed to small children. Temperature indicators - maximum 25°C.

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Shelf life

Heparil can be used for a period of 36 months from the date of manufacture of the therapeutic agent.

Application for children

Because experience with the use of drugs in pediatrics is extremely limited, it is not used in children.

Analogues

The analogs of the drug are Venitan, Heparoid, Liogel, Venogepanol with Esfatil, Liotromb, Venosan with Hepatrombin, and also Viatromb, Dermaton, Heparin ointment, Lioton and Thrombocid with Trombles.