Hayes-steril 10%

Hayes-steril 10% is a medicinal product used for surgical purposes during operations and blood transfusions. Let's consider the features of this drug, pharmacodynamics and pharmacokinetics, side effects, methods of administration and dosage.

Hayes-steril 10% is a transparent solution, which includes: sodium chloride, hydrochloric acid, sodium hydroxide, hydroxyethyl, starch, water for injection and other components. The drug is a solution for infusions, the pharmacotherapeutic group of the drug is perfusion solutions and blood substitutes.

Indications Hayes-steril 10%

Indications for use of Haes-steril 10% are directly related to the pharmacotherapeutic group of the drug. Let's consider the main indications for the use of this drug.

• Prevention and treatment of hypovolemia and hemorrhagic shock during surgical interventions.
• Treatment of traumatic injuries, traumatic shock.
• Burn infections and burn shock, septic infections.
• Normovolemic (acute) hemodilution during surgical interventions to reduce the introduction of donor blood.
• Prevention of hemodilution for therapeutic purposes.

Release form

The drug is available in glass and plastic bottles of 500 ml and 250 ml with 10% and 6% infusion solution. The drug is sold individually or in 10 bottles per package. Plastic bottles are preferred because they do not require special transportation rules and are less susceptible to damage, which cannot be said about glass bottles with Haes-steril 10%.

Transparent vials with the preparation allow you to clearly see the solution. Thus, in case of non-compliance with storage conditions or expiration of the shelf life, small flakes may appear in the solution of Haes-steril 10%, and the preparation itself may change its color or become cloudy.

Pharmacodynamics

Pharmacodynamics of Haes-steril 10% allows you to learn how the drug behaves after entering the body and how the active substances of the drug work. The active substance of Haes-steril 10% is an artificial colloid hydroxyethyl starch, which is obtained from amylopectin. The average molecular weight of the substance is 200 thousand Daltons, and the substitution is 0.5. Such data indicate that the glucose residues of the drug account for hydroxyl groups that are close to glycogen. Due to this, the drug is well tolerated and has a low risk of developing anaphylactic reactions.

Hayes-steril 10% 500 ml infusion is designed for 15 minutes of drip administration. Use in hypovolemia leads to an increase in plasma volume by more than 140% an hour after administration and by 100% after 2 hours. Hayes-steril 10% improves hemodynamics and microcirculation for 3-5 hours.

Pharmacokinetics

Pharmacokinetics of Haes-steril 10% is the processes of administration, distribution, absorption, metabolism and excretion of the drug. After administration, the active substance of the drug undergoes cleavage (enzymatic) of the blood, which leads to the appearance of polysaccharides with different molecular weights.

The drug is usually excreted through the kidneys, half of the administered dose of the drug is excreted with urine within 24 hours. A small amount of Hayes-steril 10% is deposited in tissues, about 10% continues to work in the blood serum. Another substance of the drug - sodium chloride is excreted with sweat through the skin.

Dosing and administration

The method of administration and dosage of the drug depend on the purpose of use and are prescribed by a doctor, individually for each patient. The drug is used as intravenous infusions. The solution is administered slowly, since anaphylactic reactions are possible when administering the first 20 ml of the drug. The daily dose and rate of infusion depend on the degree of hemoconcentration and blood loss. Hayes-steril 10% has therapeutic limits that depend on the degree of dilution of the drug.

If the drug is used for the prevention or treatment of hypovolemia volume deficit, the maximum dose for adults is 20 ml per kg of body weight per day, the infusion rate is 20 ml/kg. The maximum daily dosage and rate of administration are prescribed by the doctor and depend on the individual characteristics of the patient's body.

Use Hayes-steril 10% during pregnancy

The use of Hayes-steril 10% during pregnancy, as well as any other drug, is not advisable. But studies on the effect of the drug on the mother's body and the development of the baby have not been conducted. The drug Hayes-steril 10% during pregnancy and breastfeeding is prescribed for vital indications of the mother and only in the case when the potential benefit to the woman is much more important than the possible risk to the child's body.

When using the drug by pregnant women, side effects may occur. In this case, it is recommended to stop using the drug and carry out therapeutic procedures to cleanse the body of the active substances of Haes-steril 10%.

Contraindications

Contraindications to the use of Hayes-steril 10% are associated with the individual characteristics of the patient's body. But there are a number of cases when the drug is prohibited for use, that is, it has contraindications for medical reasons. Let's consider the main contraindications to the use of Hayes-steril 10%.

• Heart failure;
• Renal failure;
• Intracranial bleeding and blood coagulation disorders;
• Allergy to starch;
• Patient age up to 10 years, pregnancy and lactation period;
• Intracranial and arterial hypertension;
• Hemorrhagic diathesis and hypocoagulation;
• Cardiogenic pulmonary edema and hypervolemia;
• Thrombocytopenia and hemodialysis.

Before taking the drug, the doctor conducts diagnostics of the patient's body to determine possible contraindications. If contraindications exist, then Haes-steril 10% is replaced with safer analogues or the safest dosage is selected.

Side effects Hayes-steril 10%

Side effects of Hayes-steril 10% may occur when using the drug in patients who have contraindications for use. Side effects occur due to an incorrectly prescribed dose or with prolonged use. Very rarely, Hayes-steril 10% causes anaphylactic reactions of varying severity. Also, allergic skin reactions, tachycardia, decreased blood pressure, headache and dizziness are possible.

With prolonged use of Hayes-steril 10% or the use of high doses, patients may experience severe itching, which is almost untreatable. In other patients, the drug causes vomiting, bronchospasm and can lead to respiratory arrest and cardiac failure. High dosage of the drug is the cause of bleeding. That is why, when using Hayes-steril 10%, special attention is paid to the time of administration of the drug, the duration of treatment and dosage.

Overdose

Overdose of the drug Hayes-steril 10% may occur due to too rapid administration of the drug or due to incorrectly calculated dosage. Thus, high doses of the drug may cause prolongation of bleeding time, but do not cause clinically dangerous bleeding. Due to overdose, the level of hematocrit and protein dilution may decrease.

In order to avoid overdose symptoms, the drug is administered very slowly. During the infusion, the doctor monitors the patient's condition and controls the rate of administration. If overdose symptoms occur, Haes-steril 10% is stopped for treatment and prevention, replacing it with a safer analogue.

Interactions with other drugs

Interaction of Hayes-steril 10% with other drugs is possible only upon doctor's prescription. If the drug interacts with aminoglycoside antibacterial agents, then the nephrotic effect may increase, that is, the negative impact on the kidneys. Hayes-steril 10% is not recommended to be mixed with other drugs and administered simultaneously. Since this can cause anaphylactic shock, cause bleeding and other side effects.

Injections of other drugs are recommended to be done 2-3 hours after the introduction of Hayes-steril 10%. This will avoid unwanted interactions of drugs. In addition, with sequential administration, there is a guarantee that all antibiotics will be normally absorbed by the body and will have their therapeutic effects without losing them.

Storage conditions

Storage conditions for Haes-steril 10% are described in the instructions for the drug. The drug should be stored in a cool place, protected from sunlight and children. The storage temperature should not exceed 25°C.

Please note that failure to comply with storage conditions leads to spoilage of the drug. Due to temperature changes, Haes-steril 10% can change its consistency, from a transparent solution to a cloudy liquid with flakes. In this case, you should stop using the drug.

Shelf life

The shelf life of Haes-steril 10% is five years from the date of manufacture, which is indicated on the packaging of the drug. The drug must be stored in the original packaging, observing the storage conditions of Haes-steril 10%, which are specified in the instructions for the drug. Upon expiration of the expiration date, the drug must be disposed of. It is strictly prohibited to use Haes-steril 10% after the expiration date.