Grover's transient acantholytic dermatosis: causes, symptoms, diagnosis, treatment

Grover's transient acantholytic dermatosis was first described in 1970 by R. W. Grover. In scientific literature it is called Grover's disease.

The causes and pathogenesis of Grover's transient acantholytic dermatosis have not been fully studied. However, most authors express the opinion that UV radiation plays a decisive role in the development of this disease. The disease most often occurs in people with a nervous disorder, predisposed to allergic reactions, and especially sensitive to ultraviolet rays.

Symptoms of Grover's transient acantholytic dermatosis. The disease is observed mainly in middle-aged and elderly men. Bright red nodules of a hard consistency appear on unchanged or edematous erythematous, and sometimes on healthy skin. On the surface of the nodules, scales, crusts or vesicles can be observed, similar to papules-vesicles in s trophulus. The presence of itching is considered a characteristic symptom of the disease. The rash is most often located on the neck, shoulders, chest and lumbar parts of the body, mainly giving frequent relapses in the summer months.

Histopathology. The presence of acantholytic lesions in the epidermis is considered a pagognomonic symptom characteristic of this disease. However, histopathological changes on the skin resemble pemphigus, Darier's disease and Hailey-Hailey disease.

Differential diagnosis. The disease should be distinguished from Darier's disease, Hailey-Hailey disease, pemphigus, and adult pruritus.

Treatment of Grover's transient acantholytic dermatosis. In mild cases, vitamin A, antibiotics, and corticosteroid ointments are recommended. If these procedures do not help or the disease is severe, then corticosteroids (daily dose of 10-15 mg prednisolone) or aromatic retinoids are prescribed.