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Hematologist, oncohematologist

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Glutamate dehydrogenase in the blood

Alexey Portnov, medical expert
Last reviewed: 23.04.2024

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The reference values (norm) of the activity of glutamate dehydrogenase in serum are less than 4 IU / l.

Glutamate dehydrogenase catalyzes the conversion of glutamic acid to alpha-ketoglutaric acid and ammonia; The enzyme is concentrated in the mitochondria of cells, mainly in hepatocytes. It is also found in a small amount in the nervous tissue, skeletal muscles, myocardium and mammary gland.

Glutamate dehydrogenase - one of the organ-specific enzymes, is determined in the blood serum for liver diseases.

Since the enzyme is mitochondrial, the degree of increase in its activity reflects the depth of cytolysis in liver diseases, its level can be used to judge the severity of the pathological process.

trusted-source [1], [2], [3], [4], [5], [6], [7], [8]

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