Medical expert of the article
New publications
Preparations
Gentaxan
Last reviewed: 10.08.2022
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Gentaxan is a combination substance with antimicrobial activity and a prolonged type of exposure. Used only locally.
[1]
Indications Gentaxan
It is applied in case of such violations:
- infected wounds in various places with different etiologies;
- infected wounds after surgical procedures (abscesses with phlegmon and postoperative suppurations);
- having a 2nd or 3rd degree burns;
- trophic ulcers, appearing in connection with insufficiency of veins in chronic form, thrombophlebitis in the area of saphenous veins on the legs or with atherosclerosis obliterans ;
- erysipelas of different types;
- bedsores ;
- weakening of the regenerative processes associated with a weakened immune system, diabetes mellitus or radiation damage;
- preventing the development of sepsis that occurs when purulent infections are extensive;
- preventing the formation of keloids.
Release form
The release of the drug is produced in the form of a powder for external treatment, in bottles with a capacity of 2 g or dropper bottles of 5 g.
Pharmacodynamics
The drug contains an aminoglycoside substance gentamicin sulfate, and in addition, an organic silicon sorbent (metoxan substance) and a coordination zinc-tryptophan bond.
Gentamicin Sulfate Element is an antibiotic with an extensive range of bactericidal activity. It demonstrates high efficiency in eliminating disease-causing Gram-positive (Staphylococcus aureus, Mycobacterium and Streptococcus) and negative bacteria (Shigella, Klebsiella, Serra, Salmonella, intestinal bacilli, and in addition, citrobacterium, Aerobacter aeruginosa, synegmic chalice, and intestinal sticks, and in addition, citrobacter, Aerobacter aeruginosa, synegna, and syephous cholori men, and intestinal sticks.
Polymethylsiloxane helps to provide a sorption-detoxification effect, and in addition, in combination with zinctryptophan, it has an antibacterial effect (for 8 days).
Genaxaxan already on the 2-3rd day reduces the number of microbes inside the wound to the extreme lower mark (101-103 per 1 g), and at the same time increases the rate of transition from the hydration stage to the dehydration stage and prevents the occurrence of suppuration. Sorption activity allows the drug to absorb toxic products of functioning of pathogenic bacteria, toxic metabolic products of connective tissues, having a low molecular weight character (lactate polypeptides, pyruvic acid, lipids with amino acid oxidation products, etc.), as well as fibrin degradation products.
The drug acts not only by preventing protein binding to bacteria, but also by breaking down the plasma membrane bilipid layer. The drug reduces the severity of systemic and local intoxication, providing a draining effect, antibacterial activity, and besides stabilizing gas exchange, the pH level and microcirculation inside the wound. Thanks to all this, the wound is cleared of the elements of tissue decomposition and functioning, and in addition there is a stimulation of the growth of granulations, improvement of regeneration, prevention of the formation of keloids and the treatment of inflammation.
Gentaxan is used to heal burns, because it reduces the size of deep lesions, reduces inflammation during their treatment, prevents tissue destruction, increases the rate of formation of the granulation surface in the case of deep lesions and produces epithelization in case of burns of a superficial nature. In addition, the drug helps to prepare the wound for autodermoplasty.
Dosing and administration
Gentaxan is a drug for local treatment, which is used throughout the course of treatment of wound surfaces, until they are completely healed.
At the initial stage (1-5th days) it is necessary to change the bandage 1-2 times a day, and later, when the inflammation subsides, the wound is cleared of masses of pus and necrotic tissues and the process of granulation begins, this procedure is performed 1 time per 2 of the day
Wound lesions should be treated using a special drip tube with a hole. The procedure is performed after surgical manipulations and rinsing of the affected area with antiseptic solutions (the skin after this must be dried so that the medicinal substance is laid evenly (with a layer of 0.5-1 mm), completely covering the wound). If the lesion is too extensive (for example, a burn), about 8-12 g of the drug can be applied at a time.
After powder treatment, drainage is performed, followed by the application of a tight dressing. In case of burns, the lesion area is treated with medicine for 5-6 days (use up to 15 days is allowed). It is necessary to fix the medicine on the wound using a disinfecting bandage.
When dressings are very important to completely remove the remaining powder from the wound site, using antiseptics or special shampoos for treating wounds. You can apply the medicine on any areas of the patient's body.
In case of injuries (if it is impossible to perform a full surgical treatment), 1-4 g of powder is powdered (the amount of the substance depends on the damage site), and then a bandage is applied on it (for a maximum of 24 hours).
[4]
Use Gentaxan during pregnancy
Now there is no information regarding the use of drugs during lactation or pregnancy. If the medication is to be used during these periods, the doctor should evaluate the expediency of his appointment, taking into account the individual characteristics of the patient, identified during diagnosis.
Contraindications
It is contraindicated to use the powder with a strong sensitivity to drug elements.
Overdose
In case of intoxication, signs of allergy may develop, in which it is necessary to carry out desensitization treatment and completely abolish the use of drugs.
Storage conditions
Gentaxan must be kept in a dark and dry place, at temperature values within the limits of 15-25 ° C.
[8]
Shelf life
Application for children
Gentasept allowed to appoint children of any age, because it has a non-systemic effect, providing only superficial effects, and has no resorptive properties.
Analogs
Analogues of drugs are drugs Inflaraks, Trofodermin with Fastin, and in addition, Streptonitol and Levosin.
Reviews
Gentaxon receives excellent reviews from patients. The comments indicate that it acts as quickly and efficiently as possible, is extremely convenient to use due to the special traffic jam-dropper, and also has a low cost.
Attention!
To simplify the perception of information, this instruction for use of the drug "Gentaxan" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.