All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Gangleron
Medical expert of the article
Last reviewed: 23.04.2024
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Gangleron
Gangleron is used for such diseases as:
- acute and chronic cholecystitis,
- cholangitis,
- hepatitis,
- peptic ulcer of the stomach and duodenum,
- dyskinesia of the digestive system with spasms, a violation of the motility of the gastrointestinal tract,
- defeat of the nodes of the sympathetic trunk of different localization (ganglionvrit, ganglionitis),
- angina (to prevent seizures).
Pharmacodynamics
The active substance of the ganglionic Gangleron -3-diethylamino-1,2-dimethylpropyl ester, parabutoxybenzoic acid in the form of hydrochloride, prevents the effect of acetylcholine on the nicotinic receptors (n-cholinergic receptors) of autonomic nerve nodes (ganglia) located on their membranes and disrupts the process of polarization and excitation postganglionic neurons.
As a result, the passage of nerve impulses from peripheral organs through the ganglia to the central nervous system occurs, which in turn inhibits their functions (including motor and secretory ones). At the same time, reflex spasms of the smooth muscle tissues of the organs and walls of the vessels are removed.
In addition, Gangleron promotes vasodilation and a reduction in peripheral resistance to blood flow, which reduces systolic blood pressure.
Dosing and administration
Ganglionone in capsules is taken orally - one capsule three times a day (before meals): the maximum daily dose is 0.3 g.
Solution for injection is injected intramuscularly or subcutaneously - 4 ml; the maximum daily dose is 12 ml.
[11]
Use Gangleron during pregnancy
Not provided.
Contraindications
Among the contraindications of the drug Gangleron, renal and hepatic insufficiency, vascular hypotension, decreased motility of the gastrointestinal tract, atony of the bladder, glaucoma, thrombosis, children's age are noted.
[9]
Side effects Gangleron
The use of Gangleron may cause general weakness, dizziness, orthostatic BP depression, increased heart rate, dry mouth, constipation, decreased tonus of the muscular walls of the bladder, accommodation disorder, dilated pupils.
[10]
Overdose
Although gangliobloktorav in large doses can cause respiratory depression, Gangleron's instructions indicate that there are no cases of his overdose.
Storage conditions
Ganglerone should be stored at room temperature, in a dark place.
Shelf life
Gangleron capsules - 24 months, in ampoules - 36 months.
Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Gangleron" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.