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Last reviewed: 20.11.2021

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Fibrinogen (factor I) is a protein synthesized mainly in the liver. In the blood, it is in a dissolved state, but as a result of the enzymatic process, under the influence of thrombin and factor XIIIa it can turn into insoluble fibrin.

Fibrinogen refers to the proteins of the acute phase, and its concentration in the plasma increases with infection, inflammation, trauma and stress. Synthesis of fibrinogen stimulates hormones (insulin, progesterone), fatty acids and PDF. Nevertheless, the main stimulator of fibrinogen synthesis is the secretion of IL-6 by macrophages and monocytes in response to phagocytosis of PDF. The concentration of fibrinogen in the blood plasma is increased in smokers who have diabetes mellitus. As the concentration of fibrinogen increases, the risk of cardiovascular diseases increases. In women, the concentration of fibrinogen is higher than that of men, and their increase with age is more noticeable.

Reference values (norm) of fibrinogen concentration in blood plasma


Concentration of fibrinogen

Mg / dL

G / l

Newborn Adults

125-300 200-400


trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9]

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