Femoden

Femoden has estrogen-gestagen and contraceptive properties.

[ 1 ]

Indications Femodena.

It is used as a contraceptive. In addition, it can be used to stabilize the menstrual cycle and reduce extremely heavy menstrual bleeding.

[ 2 ], [ 3 ]

Release form

The product is released in the form of dragees, inside blister packs.

[ 4 ], [ 5 ]

Pharmacodynamics

The drug is part of a group of drugs that have a low hormonal dosage. It affects the system that includes the pituitary gland with the hypothalamus and the ovaries.

The drug inhibits the process of binding hormones that stimulate follicular maturation. It also causes a slowdown in ovulation and activates changes in the processes of secretion of cervical mucus.

Femoden has no androgenic activity. In addition, it reduces the susceptibility of the endometrium to blastocyst attachment.

[ 6 ]

Pharmacokinetics

When taken orally, ethinylestradiol and gestodene are absorbed completely and at high speed. During the first liver passage, gestodene is not subject to breakdown, but most of the ethinylestradiol, on the contrary, enters into metabolic processes. The latter is also synthesized to a greater extent with intraplasmic protein. In addition, it passes into breast milk.

The bioavailability level of the drug is 99%. Gestodene is synthesized with plasma albumin, which is capable of binding sex steroids, and also with globulin.

Excretion of gestodene and ethinyl estradiol occurs in the form of decay products - with bile and urine.

[ 7 ], [ 8 ], [ 9 ]

Dosing and administration

The medicine should be taken orally, daily and at approximately the same time of day. The pills are swallowed whole, washed down with plain water. The drug should be taken 1 pill per 21 days. Then the patient should take a 7-day break, after which resume taking it. Menstrual bleeding often begins on the 2-3rd day from the start of the break and may end even before switching to a new pack of drugs.

Women who have not previously used any hormonal contraceptives should take Femoden from the 1st day of the menstrual cycle or from the 2nd to the 5th day. At the same time, during the 1st week of the course, it is recommended to use additional contraceptives.

Women who have previously taken other combination medications for oral administration should take the medicine on the day following the last drug. It is prohibited to start taking it later than the day following the end of the standard 7-day break for the period of menstruation.

When switching from medications containing only gestagens or from intrauterine devices releasing gestagens, you can start taking Femoden on any day. If an intrauterine drug or implant was used, the course begins immediately on the day of its removal. If an orally administered solution was used, the start falls on the following day. At this time, in the first week of the course, you need to use additional (barrier) contraceptives.

Women who had an abortion in the first trimester should start taking the drug immediately. There is no need for additional protective measures. Those who had an abortion in the second trimester or after childbirth are recommended to start using the drug after 3-4 weeks. When starting to use it at a later period, it is necessary to make sure that there is no pregnancy and use additional contraception for the first time.

If you miss a dose of the medicine (for a period of less than 12 hours), its contraceptive effect will still be effective. You need to take the medicine as soon as possible, and take the next dose at the standard time. If you miss a dose for more than 12 hours (but not longer than 7 days), the required dose should be taken as soon as possible. Then take the medicine as usual. During the entire next week, you should protect yourself from pregnancy with additional means. In addition, it is necessary to exclude the possibility of an existing pregnancy.

If you miss taking the medicine for a period longer than 12 hours in the 3rd week of taking it, you need to take it as soon as possible, then continue taking it at the standard time until the start of a new pack. Before its end, the likelihood of bleeding is quite low. During this period, when taking the medicine, spotting and slight bleeding may occur. At the same time, you can take a standard 7-day break after finishing the 1st pack, and only then start a new one.

If you miss a dose and there is no menstrual bleeding during the standard 7-day break, it is imperative to exclude the possibility of pregnancy.

If a woman develops diarrhea or vomiting during the first 4 hours after taking the medication, additional barrier contraception must be used for protection. In addition, it is necessary to follow the application schemes when a dose is missed.

There are also situations when it is necessary to postpone the menstrual cycle. In this case, the medicine should be continued to be used, without observing a 7-day break, for the required period, until the end of the 2nd pack. At this time, slight bleeding may occur, as well as spotting. After the end of the 2nd pack, a 7-day break is required.

[ 14 ], [ 15 ], [ 16 ]

Use Femodena. during pregnancy

The use of Femoden during pregnancy is prohibited.

Contraindications

Main contraindications:

• the presence of high sensitivity to medicinal components;
• liver tumors (also their presence in the anamnesis);
• migraine (with a history of focal reactions of a neurological nature);
• severe stage of diabetes mellitus, accompanied by complications in relation to the vascular system and severe form of hypertriglyceridemia;
• uterine bleeding of unknown origin;
• severe stages of functional liver disorders;
• thromboembolism (also its presence in the anamnesis or a high probability of its occurrence);
• pancreatitis accompanied by a severe stage of hypertriglyceridemia (also a history).

[ 10 ], [ 11 ], [ 12 ]

Side effects Femodena.

The use of the medication may provoke the appearance of the following side effects:

• chloasma, urticaria, hypersensitivity to contact lenses, rashes, anaphylaxis and angioedema;
• nausea with vomiting and changes in weight indicators;
• fluid retention, nipple discharge, chest pain, changes in vaginal discharge or libido, and in addition, breast engorgement;
• headaches, migraines, mood lability;
• tachycardia.

[ 13 ]

Overdose

Poisoning with the drug can cause tachycardia, vaginal bleeding, vomiting with nausea and spotting.

Femoden has no antidote. The treatment regimen should be selected by the attending gynecologist.

Interactions with other drugs

Certain antibiotics can lead to a decrease in the values of the active elements of the drug in the blood plasma. In addition, such medications as phenylbutazone and hydantoin with rifampicin can weaken its effectiveness.

[ 17 ], [ 18 ], [ 19 ], [ 20 ]

Storage conditions

Femoden must be kept at a temperature not exceeding 25°C.

Shelf life

Femoden can be used for 5 years from the date of manufacture of the drug.

Reviews

Femoden receives many different reviews on forums, but no negative opinions are written about it. Although many women note the presence of many negative symptoms. They often complain of vomiting with nausea, mood lability and weight gain. But those who found the medicine suitable, speak only positively about it.

Doctors confirm that the drug can cause negative effects - often because the drug is simply not suitable for these people. At the same time, it is often prescribed to patients not only as a contraceptive, but also to treat inflammation in the endometrium (in combination with anti-inflammatory therapy). Sometimes Femoden is used before the IVF procedure (in situations where there has already been an unsuccessful protocol).