Faspic

The well-known non-steroidal anti-inflammatory drug ibuprofen, an effective antipyretic analgesic, is now presented by Swiss pharmacists in a new dosage form of granules for the preparation of an oral solution, flavored with various flavor additives that mask the bitter taste of the active ingredient.

Under this trade mark Faspic, a tablet form is also produced in the form of a salt of the L-isomer of aliphatic arginine acid, which contributes to some increase in the absorption and effectiveness of ibuprofen.

Indications Faspika

Symptomatic relief of joint, muscle, headache, menstrual, dental, neuralgic pain, as well as pain and fever syndrome associated with acute viral infections, flu and colds.

Release form

This medication is available in solid form of tablets coated with a gastro-soluble shell, which contain 0.4 g of the active substance - ibuprofen, as well as in granulated form for the preparation of a warm drinking solution, packaged in sachets:

• Faspic with mint flavor contains 0.2 g of active ingredient and excipients: sodium bicarbonate, synthetic sweetener - aspartame, L-arginine, saccharinate, cane sugar, food flavoring "mint";
• Faspic with apricot flavor is available in two dosage options of the active ingredient: 0.4 and 0.6 g, and differs from the previous type by the presence of the food flavoring “apricot” in the composition;
• Faspic with mint-anise flavor is available in two dosage options of the active ingredient: 0.4 and 0.6 g; the auxiliary composition of this type contains two food flavors - mint and anise.

In all forms, the active ingredient (ibuprofen) is contained as a salt of the L-isomer of the aliphatic acid arginine.

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Pharmacodynamics

The action of this drug is determined by the presence of ibuprofen in its composition - a non-hormonal substance that reduces the production of inflammation mediators. The mechanism of this phenomenon is associated with the suppression of the enzymatic activity of cyclooxygenase - a catalyst for the production of prostaglandins from arachidonic acid. A decrease in their number in the hypothalamic thermoregulation center causes a decrease in the patient's body temperature, while only abnormally high temperatures are selectively reduced; if this indicator is normal, then there is no decrease.

As a result of the decrease in prostaglandin levels, sensitivity to pain mediators decreases.

Inhibition of cyclooxygenase also affects the synthesis of the endogenous proaggregant thromboxane, thinning the blood and having a thrombolytic effect.

Pharmacokinetics

The active substance is absorbed in the digestive tract at a good rate and distributed in the body tissues. The maximum plasma content is determined after 15 minutes, sometimes this period is extended, but does not exceed half an hour from the moment of administration.

Splitting occurs in the liver, excreted in the urine as inactive metabolites. The half-life of the active substance in the blood is from one to two hours.

Dosing and administration

To reduce the likelihood of developing digestive disorders, it is recommended to take the drug during meals.

For elderly patients, as well as those with severe organic or functional disorders of vital organs, the dose is adjusted downwards.

Tablets: at the beginning of treatment, one tablet is dosed per dose, no more than 1.2 g of the drug can be taken per day, the interval from one dose to the next should be at least four hours. The tablet is swallowed whole, washed down with clean water in the required volume.

The solution is prepared as follows: pour the granules from the bag into ½ glass of warm boiled water, dissolve, shaking slightly. Take immediately after dissolution. The rules for taking are similar to tablets.

The maximum single dose of the active substance is 0.6 g.

The duration of taking any form should not exceed a week.

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Use Faspika during pregnancy

The drug is contraindicated for pregnant women and nursing mothers, and is also not recommended for patients planning pregnancy.

Contraindications

1. Sensitization to the ingredients of the drug, history of NSAIDs (in particular, the aspirin triad).
2. Pregnancy and lactation.
3. A course of treatment with another cyclooxygenase inhibitor.
4. Low prothrombin index, hemorrhagic diathesis, unspecified bleeding tendency, hemophilia.
5. Phenylketonuria.
6. Gastrointestinal hemorrhages, perforations and ulcerative-erosive lesions, acute and in history.
7. Severe and progressive cardiac, renal and hepatic failure.
8. Age 0-11 years, for a dose of 0.6 g – 0-18 years.
9. Pathologies of the optic nerve.
10. Hyperkalemia.
11. Congenital sucrase-isomaltase deficiency, fructosemia, galactosemia.

Use with caution in elderly patients suffering from diabetes mellitus, collagenoses, liver and kidney dysfunction, bronchial asthma and those prone to bronchial spasms, taking medications that increase the likelihood of hemorrhages.

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Side effects Faspika

With short-term treatment with this drug, the most likely development of skin and respiratory allergic reactions is up to anaphylactic shock.

Long-term use may provoke the development of the following phenomena:

Digestive organs: abdominal pain, nausea, vomiting (possibly with blood), bloating, diarrhea, heartburn and other digestive disorders, erosive and ulcerative lesions along the digestive tract, gastrointestinal hemorrhages (possibly intense with the risk of death); there is a risk of developing inflammatory processes in the pancreas, esophagus or duodenum, Crohn's disease, jaundice, hepatonecrosis, liver inflammation and dysfunction.

Neurology: migraine-like pain that cannot be relieved by non-narcotic analgesics even in high doses; dizziness, tinnitus, drowsiness, emotional lability or, on the contrary, increased excitability, insomnia, anxiety, restlessness, muscle spasms, hearing impairment.

Urogenital system: acute renal dysfunction, urination disorders, inflammatory and degenerative processes along the urinary tract, fertility disorders;

Hematopoietic organs: agranulocytosis, anemia (including aplastic), decreased quantitative indicators of blood cell content: leukocytes, platelets, erythrocytes, increased levels of eosinophils;

Heart and blood vessels: a sharp decrease in blood pressure up to the development of a comatose state; heart rhythm disturbances, increased heart rate; symptoms of cardiac and cerebral vascular insufficiency; high doses of the drug can provoke the development of acute stroke, arterial thromboembolism.

Sensitization reactions: from urticaria and allergic rhinitis to shock.

Eyes: color vision problems, visual acuity problems, lazy eye.

In individuals with collagenoses, aseptic meningitis may develop.

The risk of adverse effects from taking the drug is significantly reduced with short-term use at the minimum effective dosage.

Overdose

Exceeding the recommended dosage may cause any of the side effects or a combination of them in an acute form, including shock, which can be fatal.

Therapy is carried out according to the symptoms. If the time interval from the moment of taking a large amount of the drug is no more than half an hour, you can wash the stomach and give activated carbon or enterosgel. The antidote is not known.

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Interactions with other drugs

Combination use of the following medications with ibuprofen may cause consequences:

• the formation of multiple erosive and ulcerative lesions of the mucous membrane of the digestive tract and bleeding from them - drugs that selectively inhibit the synthesis of serotonin, prevent the formation of blood clots, glucocorticosteroids;
• decreased effectiveness of hypotensive and diuretic drugs;
• increased plasma concentrations of cardiac glycosides, methotrexate and lithium;
• enhancing the effect of drugs that reduce blood clotting and sugar levels;
• the toxic effect of cyclosporine and tacrolimus on the kidneys increases;
• reduction in the effectiveness of mifepristone (the interval between doses of the drug should be at least eight days);
• increased risk of seizures in patients taking quinolone antibiotics.

Faspic should not be combined with other NSAIDs or alcoholic beverages.

Patients with HIV infection taking zidovudine should be aware that concomitant administration of Faspic increases the risk of hemarthrosis and bruising.

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Storage conditions

Store at a temperature of 15-25℃. Keep out of reach of children.

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Shelf life

3 years.