Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Deficiency of antithrombin: causes, symptoms, diagnosis, treatment

Medical expert of the article

Hematologist, oncohematologist
, medical expert
Last reviewed: 23.04.2024

Antithrombin is a protein that inhibits thrombin and factors Xa, IXa, Xla.

trusted-source

Epidemiology

The prevalence of heterozygous deficiency of plasma antithrombin is from 0.2 to 0.4%. Venous thromboses develop in half of heterozygotic individuals. Homozygous deficiency leads to fetal death in utero. Acquired deficiency occurs in patients with ICE, liver disease, nephrotic syndrome, with therapy with heparin or L-asparaginase.

trusted-source[1], [2], [3]

Forms

The mutation of the prothrombin 20210 gene leads to an increase in the plasma prothrombin level and an increased risk of venous thromboembolism.

trusted-source[4], [5], [6], [7], [8], [9], [10], [11], [12]

Diagnostics of the antithrombin deficiency

Laboratory determination of deficiency includes quantification of the plasma thrombin inhibitor in the presence of heparin.

trusted-source[13], [14]

Who to contact?

Treatment of the antithrombin deficiency

Taking warfarin by mouth is used to prevent venous thromboembolism with an antithrombin deficiency.

More information of the treatment


The iLive portal does not provide medical advice, diagnosis or treatment.
The information published on the portal is for reference only and should not be used without consulting a specialist.
Carefully read the rules and policies of the site. You can also contact us!

Copyright © 2011 - 2025 iLive. All rights reserved.