All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Dalfaz retard
Medical expert of the article
Last reviewed: 03.07.2025
Dalfaz retard is an alpha-adrenergic blocker. Drugs from this group block adrenergic synapses, which leads to the expansion of precapillaries and arterioles. In addition, Dalfaz retard improves the process of urine excretion in case of prostate enlargement.
Dalfaz retard helps improve the condition of patients with benign formation in the prostate gland. The medication improves general well-being, facilitates urination, and relieves pain.
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Dalfaz retard
Dalfaz retard is used to treat benign tumors in the prostate gland.
Release form
The medication is available in the form of light beige film-coated tablets.
Pharmacodynamics
The active substance of Dalfaz retard is alfuzosin, which is active when taken orally.
Alfuzosin blocks adrenergic receptors located in the triangle of the bladder, prostate gland, and urethra.
In the case of a benign tumor in the prostate gland, smooth muscle contraction occurs, which prevents the outflow of urine and leads to disruption of the bladder.
Dalfaz retard directly affects the smooth muscles of the prostate gland tissue and improves urine flow, reduces pressure in the urethra, and facilitates urination.
Pharmacokinetics
Dalfaz retard reaches its highest concentration in the body 3 hours after use. The half-life of the drug in the body is eight hours.
The therapeutic effect of the drug does not depend on food intake.
The active substance (alfuzosin) of the drug breaks down mainly in the liver, 11% of the substance is excreted by the kidneys unchanged, 80-90% - in the form of metabolites in the feces.
At the age of over 75 years, the period of absorption of the drug is shortened, and the highest concentration in the body is higher.
In severe liver dysfunction, the half-life and bioavailability are increased compared to healthy patients.
When kidney function is impaired, the process of cleansing the body and the level of distribution of the drug increase.
Dosing and administration
The Dalfaz retard tablet is taken orally whole, it is recommended to wash it down with one glass of water. You need to take 2 tablets per day (morning and evening).
Adult patients are prescribed 5 mg of the drug (one tablet) twice a day.
In old age, with low blood pressure, when taking medications to lower blood pressure, 1 tablet is prescribed in the first days (preferably in the evening), then, taking into account the clinical response, the specialist can increase the dosage, but not more than two tablets per day.
In case of renal insufficiency, no dosage adjustment is required.
In case of liver failure, 1/2 tablet (2.5 mg) is prescribed once a day, then a specialist can increase the dose (no more than 1 tablet per day).
A violation of the tablet structure can affect the rate of absorption and provoke the development of side effects, so you cannot crush, chew, etc. tablets before taking.
Use Dalfaz retard during pregnancy
There have been no studies on the safety of Dalfaz retard in pregnant women.
Contraindications
Dalfaz retard should be taken with caution simultaneously with drugs that lower blood pressure, in elderly patients, with ischemia, angina pectoris, and in cases of ischemic brain disease against the background of low blood pressure.
Side effects Dalfaz retard
Dalfaz retard quite often provokes dizziness, weakness, headaches. In rare cases, cerebral ischemia and drowsiness occur.
Also possible are vision problems, decreased blood pressure, increased heart rate (rarely attacks of angina in ischemic heart disease), inflammation of the nasal mucosa, nausea, upset stomach, skin rashes, and a feeling of fatigue.
In rare cases, liver disease, liver cell damage, angioedema, redness of the skin, swelling and tenderness in the chest, painful erection not associated with sexual arousal may develop.
[ 1 ]
Overdose
Dalfaz retard, when taken in high doses, causes a decrease in blood pressure and an increased heart rate.
In case of overdose, the patient must be hospitalized and treated in a hospital with vasoconstrictors and plasma substitutes; after the condition improves, it is recommended to monitor the patient for at least 24 hours.
Blood purification is ineffective in this case, since the active substance binds to proteins to a high degree.
Interactions with other drugs
Dalfaz retard should not be taken simultaneously with urapidil, prozazin and other alpha1-adrenergic receptor blockers.
Dalfaz retard should be taken with caution with drugs to lower blood pressure, ketoconazole, itraconazole, ritonavir.
Simultaneous intake of nitrates can provoke increased heart rate and decreased blood pressure.
Anesthesia during drug treatment may cause instability of blood pressure.
Storage conditions
The medicine should be stored in a place protected from moisture and sunlight, the storage temperature should not exceed 25°C.
[ 4 ]
Shelf life
The medicine is valid for three years from the date of manufacture. If the packaging is damaged or storage conditions are not met, or after the expiration date, it cannot be used.
Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Dalfaz retard" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.