Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Coxsackie viruses

Medical expert of the article

Infectious disease
, medical expert
Last reviewed: 20.11.2021

In 1948, G. Doldorf and G. Sickles isolated from the contents of the intestine of patients with poliomyelitis-like disease of children a virus close to polioviruses, but differing from them not only in antigenic properties, but also in virulence for newborn mice (poliovirus type I and III pathogen only for monkeys, type II poliovirus can adapt to cotton rats). This virus was isolated in the town of Coxsackie (New York State), so G. Doldorf proposed to temporarily name this and similar viruses by the viruses of the Coxsackie group. This name has survived to the present day.

As it turned out, Coxsackie viruses are widespread in nature, represented by a variety of options. According to their virological and epidemiological properties, they are in many respects similar to polioviruses and play a significant role in human pathology. It should be noted that Coxsackie viruses are the most cardiotropic of all enteroviruses. In 20-40% of patients under the age of 20 years, Coxsackie infection is complicated by myocarditis. Coxsackie viruses are represented by two groups: the Coxsackie A group includes 23 serovariants (A1-A22, 24); the Coxsackie group B includes six serovariants (B1-B6).

Coxsackie viruses in group A cause mild paralysis in neonatal mice due to the defeat of skeletal musculature. Unlike them, Coxsackie viruses cause damage to the central nervous system in newborn mice, and changes in muscles are poorly expressed. Characteristic of the infection is necrosis of brown interlobular fat. In addition, some Coxsackie serovars (20, 21, 24) and all Coxsackie serovars have, in contrast to polioviruses, hemagglutinating properties.

It was also estimated that Coxsackie A viruses, unlike Coxsackie B viruses, do not multiply in human cell cultures. But it turned out that a number of serovars Coxsackie A, like Coxsackie B and polioviruses, can multiply in human cell cultures. Coxsackie A and B viruses can cause a person in addition to polio-lithoid-like diseases, sometimes accompanied by paralysis, and various other diseases with a peculiar clinic:

Along with the viruses of rubella and mumps, Coxsackie viruses C, causing pancreatitis, can play a significant role in the etiology of diabetes. It is also possible intrauterine transmission of Coxsackie viruses from the mother with a persistent form of Coxsackie infection to the fetus is a congenital chronic form of Coxsackie infection, often in the background of congenital immunodeficiency.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]


Translation Disclaimer: The original language of this article is Russian.
For the convenience of users of the iLive portal who do not speak Russian,
this article has been translated into the current language, but has not yet
been verified by a native speaker who has the necessary qualifications for this.
In this regard, we warn you that the translation of this article may be 
incorrect, may contain lexical, syntactic and grammatical errors.

The iLive portal does not provide medical advice, diagnosis or treatment.
The information published on the portal is for reference only and should not be used without consulting a specialist.
Carefully read the rules and policies of the site. You can also contact us!

Copyright © 2011 - 2021 iLive. All rights reserved.