Colpitis treatment with candles

Treatment of infectious inflammation of the vaginal mucosa includes, among other things, the use of local remedies, and doctors prescribe vaginal suppositories - a suppository from colpitis.

Indications for the use of suppositories from colpitis - various forms of colpitis (vaginitis), which can be caused by staphylococci or streptococci (nonspecific infection), diagnosed on the basis of bacteriological examination of vaginal secretions , Trichomonas vaginalis, Gardnerella vaginalis, Candida Albicans, Candida glabrata or Candida parapsilosis.

[1], [2], [3], [4], [5], [6], [7], [8]

Pharmacodynamics and pharmacokinetics of suppositories from colpitis

Active substance suppositories Betadine povidone-iodine, which is an antiseptic and a strong bactericidal substance, leading to cell death and spores of bacteria and protozoa. A suppository chlorhexidine in the same way behaves chlorhexidine diklukonat.

Active substance of suppositories Metranidazole - antibiotic 5-nitroimidazole - is effective in anaerobic bacterial and bacteroid infections, Gardnerella and Mobiluncus. Preventing the synthesis of nucleic acids in the DNA of microorganisms, the drug causes their death. Almost the same mechanism of action (at the level of DNA damage of microbial cells and Trichomonas cells) in suppositories of Dalacin (in which the antibiotic clindamycin), Neo-Pentotran (metronidazole + miconazole), Serconazole and antiprotozoal suppositories Trichomonacid.

Pharmacodynamics of suppositories from colpitis Gainomax is due to two active components of thioconazole and tinidazole. The first violates the processes of intracellular metabolism at the level of cytoplasmic membranes of fungi of the genus Candida, and the second penetrates directly into the cells of Trichomonads and Anaerobes and breaks the sequence of amino acids and the replication of their DNA.

Nystatin refers to polyene antibiotics, which have a destructive effect on the water-electrolyte balance in Candida alb. Cells. Polienovym antibiotic-macrolide is also natamycin - an active substance of suppositories Natamycin. The drug also inhibits the synthesis of protein components in the membranes of fungal cells, stopping their multiplication. The action of nystatin in Suppositories MacMiore enhances the derivative of nitrofuran, a synthetic antibacterial substance of nifuratel, which causes a violation of oxygen absorption by the cells of microbes and leads to a complete loss of their viability.

The main component of suppositories Vagikal - calendula, which in its composition has salicylic and pentadecyl acids, possessing bactericidal properties in relation to streptococcal and staphylococcal infections.

The pharmacokinetics of some vaginal globules have simply not been studied by manufacturers. Most of the active substances that make up the suppository from colpitis do not enter the blood. However, after topical application of suppositories of Dalacin about a third of a single dose of the antibiotic clindamycin within three days falls into the systemic bloodstream, but its overall impact on the body, as experts say, is insignificant.

Also in minimal volumes it is absorbed by blood and metronidazole is completely excreted in the urine of Neo-Pentotrans suppositories, but mikonazol does not enter the systemic bloodstream at all.

Names of suppositories from colpitis

It is worth mentioning the main names of suppositories from colpitis, presented to date in the domestic pharmaceutical market, the names of the trade names of the preparations are indicated in brackets:

• Betadine (Iodoxide) antiseptic suppositories prescribed for nonspecific colpitis, as well as for the candidiasis form of the disease.
• Metronidazole (Flagil) antiprotozoal suppositories are used in colpitis, the etiology of which is associated with trichomonads and gardnella.
• Suppositories Dalatsin (Klindachin, Cleocin) belong to the antibiotics of the group of lincosamide, effective for bacterial colpitis and vaginosis.
• Neo-Pentotran is a combined remedy for many types of microbial infection (including gram-positive microbes) and protozoa based on the antibiotic metronidazole and the antifungal drug Miconazole.
• Sertaconazole (Zalain) (imidazole + benzothiophene), suppository for fungal colpitis.
• Ginezol - a suppository with miconazole from a candida colpitis.
• Trichomonaside suppository for the treatment of trichomonas colpitis.
• Suppositories Gainomax can be used in various forms of colpitis, primarily caused by a nonspecific infection and Trichomonas vaginalis.
• Chlorhexidine (hexicon) - antiseptic vaginal suppositories used for nonspecific, trichomonas, as well as mixed colpitis and vaginitis.
• Nystatin (Antikandin, Fungitsidin, Fungistatin, Mikostatin, Nistafungin) is an antifungal agent, a polyene antibiotic.
• Macmirror - antifungal and antiprotozoal globules (nystatin + nifuratel).
• Natamycin (Pimafucin) antifungal suppository with polyene antibiotic.
• Vagical bactericidal and anti-inflammatory phyto-suppositories.

Dosing and Administration

All suppositories from colpitis are applied intravaginally, that is, they are injected into the vagina:

• Betadine for one or two suppositories per day, treatment course 7 days;
• Metronidazole - either once or twice a day (morning and evening), treatment course 10 days;
• Dalacin one suppository a day (at night), treatment course for three days. Macmirror is applied in the same way, but within a week. Trichomonacid is one suppository per day for 10 days.
• Gainomax and Serconazole are administered one suppository on the first day of treatment, and then one week later.
• Suppositories Neo-Pentotran, Ginezol and Natamycin should be administered one at night, for 7-14 days (Natamycin - 3-7 days).
• Globules Chlorhexidine is administered to the vagina twice a day for a week or longer (as the doctor will prescribe). A Vagical is usually applied 2-3 times a day (one candle), and the duration of application does not exceed 10-12 days.

As reported in the instructions to these drugs, given their local use, an overdose is unlikely.

Contraindications for use

Chlorhexidine and betadine can not be administered if the body is sensitive to the active substances of these agents.

The use of suppositories Metronidazole and Neo-Pentotran is contraindicated with a low level of leukocytes in the blood and pathologies of the central nervous system of an organic nature.

Gainomax is not used in the presence of diabetes, as well as in the first trimester of pregnancy and during lactation.

The use of suppositories from colpitis during pregnancy depends on the particular drug. So, the suppository from colpate Betadine, Metronidazole, Dalacin, Trichomonacid, Gainomax can not be used by pregnant women. Suppositories of Genizol are not used in the first trimester of pregnancy, and Neo-Penotran in the second and third.

There is no safety information for pregnant suppository serconazole; Suppository Nystatin is acceptable in the treatment of pregnant women only with extensive fungal infection of the genitals - under strict medical supervision. When appointing supplements Makmioror doctor should evaluate the ratio of the likely benefits for a pregnant woman with the degree of possible negative effects on the unborn child.

There are no contraindications during pregnancy of the suppository Chlorhexidine and Pimafucin.

Side effects

Side effects of suppositories Metronidazole can be expressed in the form of urticaria and skin itching, vomiting and nausea, pain in the abdominal cavity, increased dryness in the mouth, changes in taste (taste of metal in the mouth), problems with the work of the intestine and gallbladder. In addition, weakness, headache and dizziness are not excluded.

The use of suppositories Dalacin may be accompanied by irritation of the vaginal mucosa, itching and rash on the skin, the development of thrush, the violation of the menstrual cycle and urination.

Irritation of the mucous membranes is noted in the case of using such vaginal suppositories as Trichomonacid, Gainomax, Chlorhexidine, Ginezol and Neo-Pentotran. In addition, the Neo-Pentotran suppository can cause headache, dizziness, nausea, vomiting, abdominal pain, flawing sensations and stools.

Interactions with other drugs

Gainomax enhances the effect of indirect anticoagulants (to reduce the risk of bleeding the dose is reduced by 50%) and the effect of ethanol (disulfiram-like reactions). Compatible with sulfonamides and antibiotics.

Neo-Pentotrans suppositories are incompatible with the use of alcohol-containing beverages, and the parallel use of anticoagulant drugs may increase clotting time. You can not use these suppositories at the same time as cimetidine (GastroMet, Supramet, Ulceratil, etc.) used for exacerbation of gastric and duodenal ulcers, as this can cause serious side effects from the CNS.

Chlorhexidine is not used concomitantly with iodine.

Storage conditions

Suppositories Nystatin should be stored in a place protected from light and moisture, at a temperature of no more than + 5 ° C. At a temperature of +18-25 ° C, the suppository Metronidzol, Dalacin, Chlorhexidine, Serconazole, Macmiore, Neo-Pentorran should be preserved.

Shelf life: Metronidzol, Ginezol - 4 years; Dalacin, Macmirror and Neo-Pentorran are 3 years old; Trichomonacid, Gainomax, Serconazole, Chlorhexidine for 24 months.