Celestoderm-B with Garamycin
Combined drug Celestoderm-B with garyamicin for pharmacological action refers to external dermatological agents with antibacterial and anti-inflammatory properties (code ATC D07CC01).
Other trade names: Belogent, Betaderm, Akriderm Genta, Diprogen, Kuterid G.
Active substances of the drug Celestoderm-B with garyamicin - synthetic glucocorticosteroid (hormone of the adrenal cortex) betamethasone and aminoglycoside antibiotic garamycin (gentamycin sulfate).
Betamethasone removes inflammation due to inhibition of the release of arachidonic acid and the synthesis of inflammatory mediators from it, slowing the movement of leukocytes to the focus of the inflammatory process, blocking the activity of lysosomal enzymes and other biochemical processes. The reduction of itching is facilitated by the stabilization of the membranes of immune cells and the reduction of the release of histamine into the blood. A decrease in the synthesis of tissue immunoglobulins provides antiallergic effect of the corticosteroid in the composition of the Celestoderm-B ointment with garyamycin.
Gentamycin sulfate (Garamycin) has a bactericidal effect by disrupting the cell membranes of Gram-positive and Gram-negative microorganisms, which leads to a violation of protein synthesis and the death of bacteria.
Betamethasone in the Tselestoderm-B Ointment with Garamycin is adsorbed into the bloodstream in an insignificant amount (about 14%), binds to the proteins of the plasm, undergoes metabolism in the liver and is eliminated through the kidneys and intestines.
Information on the pharmacokinetics of garamycin is not available in the official instructions. Although it is noted that when applying ointment to large areas and with continued use, the level of systemic absorption of this agent is increased.
Side effects Celestoderm-B with Garamycin
The use of Celestoderm-B with garamycin can be accompanied by urticaria, the appearance of acne, dermatitis, inflamed hair bulbs and excessive hair growth, increased dry skin and burning sensation.
Prolonged use of this ointment (cream) can cause such systemic unwanted effects as weight gain, brittle bones, increased blood pressure and blood sugar. And children may have a violation of the functions of the adrenal cortex, an increase in cerebral pressure (with protrusion of the fontanel) and the development of edema of the optic nerve disk.
In addition, gramicidin can cause paresthesia, seizures, headaches, fever, angioedema and development of superinfection (or attachment of a fungal infection).