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Celestoderm-B with Garamycin
Last reviewed: 09.08.2022
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Release form
Ointment, cream (in tubes of 15 and 30 grams).
Pharmacodynamics
Active substances of the drug Celestoderm-B with garyamicin - synthetic glucocorticosteroid (hormone of the adrenal cortex) betamethasone and aminoglycoside antibiotic garamycin (gentamycin sulfate).
Betamethasone removes inflammation due to inhibition of the release of arachidonic acid and the synthesis of inflammatory mediators from it, slowing the movement of leukocytes to the focus of the inflammatory process, blocking the activity of lysosomal enzymes and other biochemical processes. The reduction of itching is facilitated by the stabilization of the membranes of immune cells and the reduction of the release of histamine into the blood. A decrease in the synthesis of tissue immunoglobulins provides antiallergic effect of the corticosteroid in the composition of the Celestoderm-B ointment with garyamycin.
Gentamycin sulfate (Garamycin) has a bactericidal effect by disrupting the cell membranes of Gram-positive and Gram-negative microorganisms, which leads to a violation of protein synthesis and the death of bacteria.
Pharmacokinetics
Betamethasone in the Tselestoderm-B Ointment with Garamycin is adsorbed into the bloodstream in an insignificant amount (about 14%), binds to the proteins of the plasm, undergoes metabolism in the liver and is eliminated through the kidneys and intestines.
Information on the pharmacokinetics of garamycin is not available in the official instructions. Although it is noted that when applying ointment to large areas and with continued use, the level of systemic absorption of this agent is increased.
Dosing and administration
Celestoderm-B with garamycin is applied topically, ointment (cream) should be applied to the affected areas of the skin with a thin layer - once or twice a day.
[11]
Use Celestoderm-B with Garamycin during pregnancy
Use during pregnancy and during breastfeeding is prohibited.
Contraindications
Celestoderm-B with garamycin is contraindicated for skin tuberculosis, mycoses, candidiasis, lesions of herpes simplex virus and chickenpox, with syphilitic rash. Ointment is not used in the treatment of children under 6 months, as well as after vaccination.
Side effects Celestoderm-B with Garamycin
The use of Celestoderm-B with garamycin can be accompanied by urticaria, the appearance of acne, dermatitis, inflamed hair bulbs and excessive hair growth, increased dry skin and burning sensation.
Prolonged use of this ointment (cream) can cause such systemic unwanted effects as weight gain, brittle bones, increased blood pressure and blood sugar. And children may have a violation of the functions of the adrenal cortex, an increase in cerebral pressure (with protrusion of the fontanel) and the development of edema of the optic nerve disk.
In addition, gramicidin can cause paresthesia, seizures, headaches, fever, angioedema and development of superinfection (or attachment of a fungal infection).
[10]
Overdose
May lead to increased side effects.
Storage conditions
Store at t <+ 25 ° C.
[15]
Shelf life
Attention!
To simplify the perception of information, this instruction for use of the drug "Celestoderm-B with Garamycin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.