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Celestoderm-B

The drug Celestoderm-B is included in the pharmacological group of hormones of the adrenal cortex; code ATC D07AC01 - corticosteroids for topical application in dermatology.

Other trade names are: Celeston valerate, Acriderm, Beloderm, Betliben, Betnoveit, Kuterid.

ATC classification

D07AC01 Betamethasone

Active ingredients

Бетаметазон

Indications Celestoderm-B

Celestoderm-B is used in the treatment of dermatitis (atopic, allergic, contact, sun), seborrhea, eczema, neurodermatitis, pruritis, psoriasis (with exudation), discoid lupus erythematosus, sclerotrophic lichen, exfoliative erythroderma, and diaper rash.

Release form

Ointment and cream (tubes of 5 and 15 grams).

Pharmacodynamics

The composition of the drug Celestoderm-B includes pharmacologically active substance - synthetic GCS betamethasone (in the form of betamethasone 17-valerate), which reduces the intensity of inflammation, hyperemia and itching of the skin, as well as exudation of all words of the epidermis and dermis.

The therapeutic effect is based on the fact that corticosteroids stimulate intracellular synthesis of lipocortin-1, which decreases the activity of phospholipase A2, inflammatory mediators, COX 1 and COX 2, and leukocytes. In addition, betamethasone reduces the synthesis of histamine and inhibits the release of phagocytes, T-lymphocytes and other immunocompetent cells into the focus of inflammation; helps strengthen the walls of the capillaries.

Pharmacokinetics

In the absence of damage to the skin, no more than 14% of Celestoderm-B is absorbed into the blood (with skin lesions and a large area of inflammation, this proportion is higher).

About half of betamethasone binds to fiery proteins; Biotransformation of the drug occurs in the liver; from the body Tselestoderm-B is excreted in the urine and feces.

Use Celestoderm-B during pregnancy

The use of Celestoderm-B in pregnant (and breast-feeding) women, like other GCSs, is undesirable. The administration of the drug is possible only in case of emergency.

Contraindications

Celestoderm-B is contraindicated to apply for dermatological pathologies of an infectious nature: acne, papular lishae, candidiasis, mycosis, impetigo. You can not use this product for skin cancer. The drug is not used in children of the first year of life.

Side effects Celestoderm-B

Among the possible side effects of Celestoderm-B are: an allergy in the form of redness, itching and rash on the skin; dryness (in the folds - maceration), burning and depigmentation of the skin in the place of application; the appearance of stretch marks; an inflammation of hair bulbs. Prolonged use of ointment or cream can cause thinning of the epidermis and skin atrophy.

Dosing and administration

Celestoderm-B is applied topically, by lubricating skin areas with a small amount of ointment or cream twice a day; it is possible to impose an occlusive dressing.

Overdose

An overdose of this drug causes an increase in side effects, and in this case, you should stop using it.

Interactions with other drugs

Features of the interaction of ointment or cream Celestoderm-B with other drugs are not described.

Storage conditions

Store at a temperature of + 25 ° C.

Shelf life

36 months.

Pharmacological group

Глюкокортикостероиды

Pharmachologic effect

Глюкокортикоидные препараты

Manufacturer

Шеринг-Плау Лабо Н.В., Бельгия

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