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Causes of high and low testosterone
Medical expert of the article
Alexey Kryvenko, medical expert
Last reviewed: 06.07.2025
Last reviewed: 06.07.2025
Diseases and conditions in which serum testosterone concentrations change
Testosterone is elevated in the following conditions:
- Uremia.
- Myotonic dystrophy.
- Liver failure.
- Klinefelter syndrome.
- Cryptorchidism.
- Primary and secondary hypogonadism.
- Kallmann syndrome.
- Use of barbiturates, clomiphene, estrogens, gonadotropin, oral contraceptives.
- Idiopathic hirsutism.
Testosterone is reduced in the following conditions:
- Men with XYY karyotype.
- Stein-Leventhal syndrome.
- Feminizing testicle syndrome.
- Precocious puberty in boys.
- Virilizing luteoma.
- Tumors of the adrenal cortex.
- Extragonadal tumors in men, arrhenoblastoma.
- Use of androgens, dexamethasone, diethylstilbestrol, digoxin, ethanol, halothane, spironolactone, phenothiazines.
- Free testosterone in serum.
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