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Causes of increased and decreased renin
Medical expert of the article
Alexey Kryvenko, Medical Reviewer, Editor
Last reviewed: 06.07.2025
Last reviewed: 06.07.2025
Diseases and conditions in which plasma renin activity may be altered
Renin is low
- Excessive salt consumption
- Adrenal cortex disorders: primary hyperaldosteronism; bilateral adrenal hyperplasia; adrenal cancer
- Low renin hypertension
- Acute renal failure
- Liddle's syndrome
- Use of diuretics, glucocorticosteroids, prostaglandins, estrogens
Renin is elevated
- Secondary hyperaldosteronism
- Renal parenchyma damage
- Liver diseases (hepatitis, cirrhosis)
- Primary adrenal insufficiency (Addison's disease)
- Right ventricular failure
- Nephrosis, nephropathy
- Renal artery stenosis
- Activation of the sympathetic nervous system
- Kidney cancer with hyperreninemia
- Neuroblastoma
- Bartter's syndrome (juxtaglomerular cell hyperplasia)