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The causes of increase and decrease of free thyroxine

Medical expert of the article

Endocrinologist
, medical expert
Last reviewed: 19.10.2021

Diseases and conditions in which the concentration of cT 4 (thyroxine) in the blood serum changes

Increase in concentration

  • Hyperthyroidism
  • Acute thyroiditis
  • Pregnancy
  • Obesity
  • Hepatitis
  • The use of estrogens (oral contraceptives), thyroid drugs, heparin, imidazole derivatives

Reduction in concentration

  • Hypofunction of the thyroid gland (myxedema)
  • Increased protein loss (kidney syndrome)
  • Isenko-Cushing syndrome
  • Androgen therapy
  • Significant deficiency of iodine
  • Exercise stress
  • Pangypopituitarism
  • Loss of protein through the digestive tract
  • The use of glucocorticosteroids, reserpine, sulfonamides, penicillin, potassium iodide
  • Resection of the thyroid gland
  • Thyroid cancer
  • Overdose of thyrostatics


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