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Biocerulin
Medical expert of the article
Last reviewed: 04.07.2025
Biocerulin is a blood substitute, a protein fraction of blood plasma.
The element ceruloplasmin is a multifunctional enzyme that contains copper. It is a glycoprotein of the α-globulin fraction obtained from human donor plasma. [ 1 ]
The substance increases the stability of cell walls (antioxidant effect and slowing down of lipid peroxidation), is a participant in ion metabolism and immune processes, and also reduces poisoning and stimulates the development of hematopoiesis. [ 2 ] Helps to non-specifically protect the body from negative external influences. [ 3 ]
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Biocerulin
It is used to reduce poisoning and maintain immunoreactivity processes during complex chemotherapy in people with oncology (this includes patients with hemoblastoses accompanied by moderate poisoning). In addition, it is used in the following cases:
- performing preparation before operations (especially in weakened people - with poisoning, anemia or severe exhaustion);
- during the early postoperative stage (in case of severe surgical blood loss, as well as purulent-septic complications);
- stimulation of hematopoiesis processes;
- combination treatment in patients with osteomyelitis in the chronic or active phase.
Release form
The drug is released in the form of an injection liquid - inside ampoules or vials with a capacity of 0.1 g. Inside the package there are 5 vials or 5 or 10 ampoules.
Dosing and administration
The medication is administered through a drip, intravenously, at a rate of 30 drops per minute.
Before use, the contents of the ampoule or vial must be dissolved in 5% glucose or 0.9% NaCl (0.2 l). The size of a standard 1-time portion is 0.06-0.1 g with administration daily or every other day (determined by the patient's condition). The therapeutic cycle includes 5 injection procedures. In total, 0.3-0.5 g of the drug is administered per course.
In oncology, during preparation before surgery, the medication is used daily or every other day in a dose of 0.5 mg/kg. The entire cycle lasts up to 10 injections (the patient's condition is taken into account). During the postoperative stage, the dosage is selected taking into account blood loss (from a dose of 0.5 mg/kg, if it is small, to a dose of 1.5 mg/kg, if it is massive). It should be used daily for a period of 5-8 days.
During chemotherapy, a single dose is 1-1.5 mg/kg, and the treatment cycle consists of 10-14 procedures (3 injections per week).
For people with hemoblastosis, a single dose is 0.5-1 mg/kg; the entire therapeutic course includes 5-8 injections (daily, once a day).
In case of active phase of osteomyelitis, 1-time dosage is equal to 1 mg/kg. During the course of treatment, 5 injections are administered daily or every other day.
If osteomyelitis is chronic, Biocerulin is prescribed in a dose of 2 mg/kg with 2-3-fold use, with a 1-2-day interval. Then the medication is administered in a dose of 1 mg/kg, 3-7 times, every other day.
- Application for children
The use of the drug in pediatrics has not been studied, therefore it is not used for this category of patients.
Use Biocerulin during pregnancy
The use of Biocerulin in breastfeeding or pregnant patients has not been studied, which is why it is not used in this group of patients.
Contraindications
It is contraindicated to use the medicine in case of severe intolerance to substances of protein nature.
Side effects Biocerulin
The use of the medication may cause the following side effects: nausea, epidermal rash (urticaria), hot flashes, short-term increase in temperature, allergy symptoms, chills and manifestations in the injection area. In case of such disorders, the dosage or injection rate is reduced or the medication is discontinued.
Clinical trials show that adverse reactions usually occur due to increased infusion rates. Low-speed drip infusions often do not cause complications.
Interactions with other drugs
The medicine must not be mixed with other medicinal substances.
Use in combination with 5% glucose or corticosteroids in high doses increases the likelihood of developing diabetes mellitus.
Storage conditions
Biocerulin should be stored in a place protected from moisture and children. Temperature level – in the range of 2-8 °C.
Shelf life
Biocerulin can be used for a 2-year period from the date of manufacture of the medicinal substance.
Analogues
Analogues of the drug are Tensiton, Albumin, Polyglyukin with Venofundin, Refortan with Hetasorb, and also Gecodez, Reopoliglyukin and Hyperhaes.
Attention!
To simplify the perception of information, this instruction for use of the drug "Biocerulin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.