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Antibodies to liver-specific lipoprotein in blood
Medical expert of the article
Last reviewed: 05.07.2025
Normally, antibodies to liver-specific lipoprotein are absent in the blood serum.
Antibodies to liver-specific lipoprotein are determined by indirect immunofluorescence. Liver-specific lipoprotein (LSP) is a heterogeneous material from hepatocyte membranes containing 7-8 antigenic determinants, some of which are liver-specific, others are non-specific. It is the antibodies to liver-specific lipoprotein that cause an autoimmune reaction with the development of antibody-dependent cytolysis of hepatocytes and provoke a relapse when glucocorticosteroids are discontinued in patients with chronic autoimmune hepatitis. The presence of antibodies to liver-specific lipoprotein in the blood serum is a distinctive feature of autoimmune hepatitis. However, it has been established that they also appear in chronic liver diseases of viral etiology (in 48-97% of cases).
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