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Alpha 2 antiplasmin
Medical expert of the article
Last reviewed: 05.07.2025
Reference values (norm) for alpha 2 -antiplasmin content in blood plasma are 80-120%.
Alpha 2 -antiplasmin is the main fast-acting plasmin inhibitor. It suppresses fibrinolytic and esterase activity almost instantly. Its mechanism of action is based on the fact that it prevents the adsorption of plasminogen on fibrin, thus reducing the amount of plasmin formed on the clot surface and thereby sharply slowing down fibrinolysis. For specific binding of alpha 2 -antiplasmin to fibrinogen, the presence of factor XIII is necessary. Alpha 2 -antiplasmin characterizes the state of the fibrinolysis inhibitor system.
Determination of alpha 2 -antiplasmin is used in a comprehensive assessment of the state of the plasmin system. When assessing the content of alpha 2 -antiplasmin, it is necessary to take into account that it depends on both the content of plasminogen and the amount of fibrinogen in the blood.
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