Alendronate stoma

Alendronate stoma is a medication that affects bone mineralization.

The component alendronate Na slows down bone resorption processes; it is an artificial analogue of pyrophosphate. The drug inhibits the activity of osteoclasts, slows down bone tissue resorption, synthesizes hydroxyapatite inside the bones, which leads to stabilization of the positive balance between bone resorption and restoration. Along with this, the mineral density in the area of the pelvic bones with the spine, etc. increases.

The drug helps to form bone tissue with a healthy histological structure.

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Indications Alendronate stoma

It is used in the following situations:

• prevention and therapy in case of osteoporosis (in postmenopausal women or to increase bone mass in men);
• therapy for osteoporosis associated with the use of GCS (men and women);
• Paget's disease.

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Release form

The therapeutic agent is released in tablets - 10 or 30 pieces in a box.

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Pharmacokinetics

The drug is absorbed inside the gastrointestinal tract – by 25%. The absolute bioavailability of a 10 mg dose (corresponding to 1 tablet), taken 120 minutes before meals, is 0.78% (in women) and 0.59% (in men). At a dosage of 40 mg it is 0.6% (in women). The element binds to intraplasmic protein by 78%. The plasma level of the drug after administration of a therapeutic dose is below 5 ng/ml.

For some time, the element is distributed within soft tissues, and then at high speed it is redistributed within bones (by 30-40% of the portion) or excreted with urine. It does not participate in metabolic processes.

Excretion is realized through the kidneys. The level of intrarenal clearance is 71 ml per minute, and the total is 200 ml per minute. The half-life is a maximum of 10 hours. In the final stage, the half-life can last over 10 years - due to the fact that the active component is released from the bones. A large amount of the substance accumulates inside the bone tissue.

When the drug is taken immediately before, with or immediately after a meal, its bioavailability values decrease. Taking it with orange juice or coffee reduces bioavailability by approximately 60%.

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Dosing and administration

The medication should be taken orally; the tablets should not be sucked or chewed. The medication should be taken on an empty stomach, 0.5-1 hour before the first meal; the tablet should be washed down with plain water (1 full glass).

Adults should take 10 mg of the substance per day (1 tablet). In case of Paget's disease - 40 mg (equivalent to 4 tablets) for six months.

For the treatment of osteoporosis, a longer cycle is required - 2-3+ years. After 3 years of therapy, the daily dose of the drug is reduced to 5 mg.

Individuals with moderate renal impairment (creatinine clearance level in the range of 35-60 ml per minute) and the elderly do not need to change dosages.

After taking Alendronate-stom, the patient must remain in an upright position for at least half an hour (lying down is prohibited).

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Use Alendronate stoma during pregnancy

The drug should not be used during pregnancy. Breastfeeding should be discontinued during therapy.

Contraindications

Among the contraindications:

• strong personal sensitivity to the drug;
• diseases affecting the esophagus that make it difficult to remove contents from it (achalasia or strictures);
• severe renal failure;
• the patient's inability to sit or stand up straight for at least half an hour;
• hypocalcemia.

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Side effects Alendronate stoma

Main side effects:

• dyspepsia, bloating, pain in the abdominal area, constipation, erosions or ulcers affecting the esophagus, diarrhea and dysphagia;
• decreased serum phosphorus and calcium levels or esophagitis;
• headaches;
• erythema or rash;
• myalgia.

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Overdose

Signs of poisoning: hypophosphatemia or -calcemia, as well as gastritis, diarrhea or esophagitis, as well as ulcers or erosions that occur in the gastrointestinal tract.

The victim should take an antacid orally or drink milk - to synthesize alendronate. He also needs to remain in an upright position at all times. Symptomatic measures are taken. Vomiting should not be induced, because this can lead to irritation of the esophageal mucosa.

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Interactions with other drugs

Combination with other medications for oral administration (including calcium-containing substances and antacids) leads to a decrease in the intensity of absorption of alendronate. Because of this, it is necessary to maintain at least a half-hour interval between the use of these drugs.

The use of NSAIDs causes potentiation of the gastrotoxic activity of alendronate.

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Storage conditions

Alendronate-stoma should be stored in a dark and dry place, out of the reach of small children. Temperature indicators are in the range of 15-25°C.

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Shelf life

Alendronate stoma is allowed to be used within a 3-year period from the date of sale of the medicinal element.

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Application for children

The use of Alendronate-stom is prohibited in pediatrics.

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