All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Agvantar
Medical expert of the article
Last reviewed: 23.04.2024
The drug Agvantar is an amino acid derivative that normalizes protein and lipid metabolism in the body. Stabilizes the main metabolism, corrects metabolic processes. Can be used with reduced appetite, lack of weight and growth, with a shortage of carnitine, and as an addition to the main course of treatment for some other diseases.
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications of the agvatara
Indications for the appointment of the drug Agvantar are manifestations of primary or secondary carnitine deficiency, as well as the following diseases and conditions:
- neurological anorexia, a lack of mass in the pathology of the psyche or due to encephalopathy;
- chronic inflammation of the walls of the stomach with signs of reduced acidity;
- chronic inflammation of the pancreas;
- rehabilitation period after operations, severe injuries or pathologies;
- premature or debilitated newborn babies (with signs of dystrophy, hypotension, poor mobility, with birth asphyxia or trauma), babies who are on hemodialysis;
- inadequate growth and underweight at the age of 16;
- initial signs of hyperthyroidism at the age of 16;
- addition of therapeutic measures for dermatological and systemic diseases;
- cardiomyopathy, ischemic heart disease, myocarditis;
- increased physical activity;
- constitutional-exogenous obesity.
Release form
Medvapratant Agvantar is made in the form of a liquid for internal reception: it looks like a transparent liquid solution of light straw color, medium density, with a characteristic odor. 20% solution is packaged in containers of 30 or 100 ml each. A special dispenser or a measuring container is supplied. Packing: Cardboard.
The active substance of the drug is levocarnitine. Of the auxiliary substances are methyl- and propylparaben, sucrose, sorbitol, water and flavors.
The drug is produced by the Irish company Shanel Medical.
Pharmacodynamics
The active substance of the drug belongs to the natural analogues of the B vitamins. This substance is produced by the liver, kidneys and brain tissue with the help of amino acids in combination with iron and ascorbic acid. The serum contains it in its free form, or in the form of acylcarnitine esters.
The effect of the drug is based on the improvement of metabolic processes of fatty acids in cardiac tissues, liver, in muscle fibers. Thanks to the effect of levocarnitine from the cytoplasm, the residual metabolic products and toxic substances are excreted, the metabolism progresses, the functional capacity improves, the development accelerates, muscle mass increases and the total lipid count in adipocytes decreases, and the basic metabolic processes stabilize in thyrotoxicosis. Weaken the signs of mechanical and psychological overload, reduce ischemic events in the heart muscle, reduce the amount of cholesterol in the bloodstream, activate the immune system at the cellular level, and increase concentration.
The effect of Levocarnitine is also used to eliminate functional disorders of the central nervous system in a number of patients with a chronic form of alcohol dependence in the withdrawal syndrome.
During significant physical exertion and active sport, endurance increases, the muscular system becomes less sensitive to pain, the function of skeletal muscles becomes active.
Pharmacokinetics
When taken orally, the drug is perfectly absorbed from the digestive system into the bloodstream. The maximum amount of active drug is detected in the blood after 3 hours. The therapeutically necessary amount of Levocarnitine in the blood can be stored for a long time - up to 9 hours.
Metabolism of the drug occurs during the formation of chemical compounds of the acyl group. Excretion from the body occurs mainly through the urinary system. Duration of half-life with oral administration of the drug can be from 3 to 6 hours, depending on the dosage of the drug taken.
Dosing and administration
Dosage and possible duration of admission Agvantar is appointed by the doctor on an individual basis, taking into account age characteristics and a specific disease.
The drug is usually taken orally for half an hour before meals. For a more accurate dosage, it is convenient to use the dispenser or measuring container provided in the packaging.
Adult patients take the drug at a primary dosage of 5 ml per day. The amount of the drug taken is gradually increased, taking into account the patient's individual reaction to the drug. The average dosage for an adult is determined in the range of 5 to 15 ml per day, can be divided into 2-3 doses. The maximum daily intake of the drug by an adult patient is 25-30 ml.
In childhood, the drug is used, starting from a daily dosage of 50 mg per kilogram of the child's weight. Agvantarum is prescribed before feeding the baby, it is possible to dilute the drug with 5% glucose solution, as well as add in kiseli, compotes, juices and other sweet drinks. The average dosage for children is determined by taking into account the age and body weight:
- newborn babies - 0.5 ml 2-3 times a day;
- To children till a year - on 0,5-1 ml 2-3 times a day;
- children from one year to 3 years - 1-2 ml three times a day;
- children from 4 to 6 years - 2-3 ml three times a day;
- children from seven to 11 years - 2.5-4 ml three times a day;
- 12 years and older - 4-5 ml three times a day.
The limiting daily norm is determined in an amount of 15 ml. Duration of treatment - from one to three months, depending on the indications. If necessary, the therapeutic course is repeated. In some cases (with a lack of carnitine in the body), Agvantar is used up to the complete relief of signs of a lack of substance.
[7]
Use of the agvatara during pregnancy
As for the possibility of using Agvantar medicinal medication in the process of bearing a child, it should be noted that sufficient specialized studies of the effect of medication in pregnant women have not been conducted. For this reason, the appointment of Agvantar is carried out only in those cases when the risk of teratogenic and embryotoxic effects is estimated to be significantly lower than the likely benefit for a pregnant woman. Treatment in this period should be conducted under constant monitoring of the condition of the future mother and baby.
If there is a need for taking Agvantar in the lactation period, breastfeeding during the entire course of use of the drug should be stopped.
In childhood, the drug is approved for use from the moment of the birth of the child.
Contraindications
Among the contraindications to the use of the drug Agvantar can be identified the presence of increased sensitivity to the components of the drug when there is a high probability of an allergic reaction.
The possibility of using the drug during pregnancy is decided by the attending doctor.
In diabetes, the drug is prescribed with extreme caution: the composition of the drug is sucrose.
The effect of the drug on the ability to drive vehicles and other complex mechanisms is not found.
Side effects of the agvatara
Possible side effects when using Agvantar:
- allergic form of dermatitis;
- disorders of digestion, stool, pain in the projection of the stomach, paroxysmal nausea;
- rarely - the appearance of convulsions, muscle weakness;
- the appearance of a characteristic odor when sweating.
Side effects are usually docked after the withdrawal of medication and do not require separate treatment.
Overdose
In case of an overdose, symptoms of dyspepsia, intensifying pain in the area of the stomach may be observed. In such cases, the drug is stopped, sorbents (activated charcoal) are taken, and gastric lavage can be done. If necessary, conduct symptomatic therapy.
Storage conditions
The drug is normally stored at room temperature, in places restricted from children's access.
Medvapratant Agvantar is released in the pharmacy network without a prescription.
[10]
Shelf life
Shelf life Agvantar - up to 2 years, subject to storage conditions. After two years of storage, the unused product is disposed of.
Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Agvantar" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.