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Extragenital diseases of the mother and premature termination of pregnancy
Last reviewed: 20.11.2021
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Extragenital diseases of the mother are one of the frequent causes of premature termination of pregnancy. The group of high risk for miscarriage is primarily women with diseases of the cardiovascular system, hypertension, chronic kidney disease, liver, intestines.
With habitual miscarriages, diseases of an autoimmune nature are closely associated - systemic lupus erythematosus, in the first place.
Disorders in the hemostasis system, congenital and acquired, are associated not only with the loss of pregnancy, but also with high maternal mortality due to thrombophilic complications: antiphospholipid syndrome, hereditary hemostasis defects, hyperhomocystinemia, thrombocythemia, etc.
With unfavorable course of pregnancy and its unfavorable outcomes in terms of miscarriage and frequent abnormalities in the fetus, such maternal diseases as insulin-dependent diabetes, hypofunction and hyperthyroidism of the thyroid, phenylketonuria in the mother, severe forms of myasthenia gravis, multiple sclerosis, and significant obesity are associated.
Premature termination of pregnancy with extragenital pathology is facilitated by significant changes in the mother's body, metabolic disorders and complications of pregnancy that accompany extragenital pathology. Vascular disorders, hypoxia, often lead to the loss of pregnancy in the pathology of the mother, and often contributes to the pharmacotherapy of the underlying diseases of the mother (iatrogenic actions).
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