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Paternal causes of non-pregnancy
Medical expert of the article
Last reviewed: 08.07.2025
Paternal causes of miscarriage play a lesser role than maternal ones, with the exception of chromosomal pathology. However, according to many researchers, husbands of women with habitual miscarriage have a high percentage of spermatogenesis disorders: oligospermia, polyspermia, teratospermia and leukocytospermia.
According to research data, when examining married couples with a history of miscarriage for protein content in sperm using the immunodiffusion analysis method, it was found that men have a marked decrease in fertility proteins. Thus, alpha2-microglobulin of fertility (AMGF), produced by the seminal vesicles, is almost two times lower compared to the control group: 21.6 ± 1.8 and 40.6 ± 2.7 μg / ml, respectively. With a deficiency of AMGF in the ejaculate, sperm migration in the female genital tract is disrupted, which can lead to disruptions in the fertilization process and the formation of a defective ovum. A significant decrease in the level of PAMG-2 (placental alpha2-microglobulin) in sperm to 16 mcg/ml and below was noted. As a result of the low content of PAMG-2, spermatozoa become “aged”, which during fertilization leads to the formation of a defective fertilized egg.
The content of salivary sperm globulin (SSG) produced by the testes is increased compared to the control group (57.9±8.9 and 17.7+2.7, respectively). The increased level of SSG is explained by the fact that, being resistant to the action of proteolytic enzymes, this protein can perform its function in inflammation foci. Inflammatory processes in men in a married couple with miscarriage are very common. Thus, according to research data, chronic prostatitis was detected in 38.8% of men, chronic urethritis - in 7.7%.
According to research, inflammatory changes in the form of prostatitis, urethritis, varicocele, and spermatogenesis disorders are observed in 42% of men in a married couple with miscarriage. Therefore, when examining a married couple, it is necessary to examine the spermogram, and if pathology is detected, refer to an andrologist for more accurate diagnosis and treatment.
It is believed that the father's chronic alcoholism is associated with the termination of pregnancy.
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