Yohimbine hydrochloride

A medicine for normalizing erectile function – Yohimbine hydrochloride – is used for various conditions and pathologies that are accompanied by erectile dysfunction.

Indications Yohimbine hydrochloride

The urological drug Yohimbine hydrochloride is prescribed by a doctor for various types of erectile dysfunction.

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Release form

The drug Yohimbine hydrochloride is a white tablet with a dosing notch. The main ingredient of the tablets is yohimbine - its amount in one tablet is 5 mg.

The drug is sold in cardboard boxes with 50 tablets in each box.

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Pharmacodynamics

The substance yohimbine is an effective means of enhancing potency and is an alkaloid preparation obtained from the bark of an African tree plant.

The principle of action of Yohimbine hydrochloride is explained by the process of selective blocking of α²-adrenoreceptors. The drug increases the central adrenalin metabolism, activating adrenergic nerve cells in the central nervous system, which provokes the development of a psychostimulating effect and exacerbation of the reaction. There is an opinion that the drug affects the serotonergic, dopaminergic, cholinergic system of nervous innervation.

It has been proven experimentally that Yohimbine hydrochloride stimulates sexual desire and stabilizes sexual function lost due to stressful situations, and restores erectile dysfunction.

The therapeutic effect is explained by the drug's effect on the central nervous system. The effect may also be associated with the expansion of the genital blood vessels and improved blood circulation in the tissues.

Periodic decreases in the effectiveness of Yohimbine hydrochloride during the second to third week of treatment may be due to the accumulation of the active product 11-hydroxyyohimbine.

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Pharmacokinetics

Yohimbine hydrochloride is fully absorbed in the digestive system within 60 minutes. The maximum content of the substance in the bloodstream is observed after 45-75 minutes.

The first pass of the drug is through the liver. The active substance does not accumulate in the tissues and fluids of the body.

Distribution in tissues is always uniform. In blood serum, 82% of the active component binds to protein, and only a small amount of the drug is found in the intercellular fluid.

Metabolic transformation of Yohimbine hydrochloride occurs in and outside the liver. Two types of metabolites have been found - the more active is 11-hydroxyyohimbine, and the less active is 10-hydroxyyohimbine.

The half-life of a single dose of the drug is from 25 minutes to 2 ½ hours. With long-term treatment, Yohimbine hydrochloride is excreted over a period of 60 minutes to 8 hours.

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Dosing and administration

Yohimbine hydrochloride tablets are taken with food and sufficient liquid. The tablet should not be chewed or crushed.

The optimal amount of the drug per day is from one to six tablets, divided into 1-3 doses.

Usually, the doctor selects the dosage individually for each patient. The initial dose may be half a tablet three times a day, with a gradual increase to 1-2 tablets three times a day.

In some cases, the effect of treatment may be delayed and develop only after 14-20 days from the start of taking Yohimbine hydrochloride.

The total duration of therapy depends on many individual factors and can range from several weeks to 1 month.

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Use Yohimbine hydrochloride during pregnancy

The drug Yohimbine hydrochloride is prescribed only to men.

Contraindications

Yohimbine hydrochloride is not prescribed only in some cases:

• if you are prone to allergies to the composition of the medication;
• in complicated arterial hypotension;
• in severe pathologies of the liver and kidneys;
• during therapy with adrenergic drugs.

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Side effects Yohimbine hydrochloride

Sometimes taking Yohimbine hydrochloride may be accompanied by adverse reactions, namely:

• increased heart rate;
• headaches, sleep disorders, irritability, hand tremors, increased sweating, feeling of anxiety;
• dyspepsia;
• hyperemia of the skin;
• increased blood pressure;
• a decrease in the daily amount of urine, prolonged erection without sexual arousal;
• allergies.

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Overdose

Taking excessive amounts of Yohimbine hydrochloride causes signs of intoxication, which include general weakness, paresthesia, memory and motor activity disorders, headache, hypertension, a feeling of fear and anxiety. Additionally, the following signs may develop:

• increased heart rate;
• dizziness;
• increased levels of norepinephrine in the bloodstream;
• dyspeptic disorders;
• salivation;
• lacrimation;
• hyperhidrosis.

After 4 hours of taking a large amount of Yohimbine hydrochloride, pain behind the breastbone may occur, which continues to bother for several hours in a row.

As a treatment, the drug is discontinued, the stomach is washed, and sorbent preparations (activated carbon) are taken.

The antidote can be the drug Clonidine, which neutralizes the mental manifestations of an overdose. It is prescribed in the amount of 0.1-0.2 mg orally. Further repeated use of Clonidine in the amount of 0.1 mg every 60 minutes is possible until the heart function stabilizes and the patient's condition improves.

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Interactions with other drugs

Clonidine can be prescribed only in case of overdose of Yohimbine hydrochloride. In other cases, these drugs neutralize each other's action.

Yohimbine hydrochloride may interfere with the effectiveness of medications that prevent high blood pressure.

Yohimbine hydrochloride improves the effectiveness of antidepressants and increases the likelihood of developing side effects, but can reduce the effect of tranquilizers.

The drug Clomipramine increases the levels of yohimbine in the bloodstream.

Yohimbine hydrochloride contains a small amount of lactose, and this should be taken into account when prescribing the drug to people with galactose intolerance, lactase deficiency, and glucose-galactose malabsorption.

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Storage conditions

It is recommended to store Yohimbine hydrochloride tablets in the original cardboard packaging, in rooms with a temperature of up to +25°C, out of reach of children.

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Shelf life

Yohimbine hydrochloride can be stored in its original packaging for up to 3 years.

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