Vibrocil

Vibrocil is a decongestant; it is a vasoconstrictor substance that acts on the nasal mucosa. It has a complex composition (dimethindene, which is an antagonist of H1 endings, as well as the sympathomimetic phenylephrine).

The drug has a long-lasting and very rapid vasoconstrictor effect on the venous bed of the nasal mucosa with paranasal sinuses. It reduces pathogenic exudation and improves the activity of the ciliated epithelium. The combination with dimethindene causes the development of an antiallergic effect. [ 1 ]

Vibrocil is a local agent, therefore its therapeutic activity is not determined by the blood level of active ingredients.

Indications Vibrocil

It is used to treat manifestations of respiratory colds (swelling of the nasal mucosa). It is also used in such cases:

• rhinitis in the active or chronic stage;
• rhinitis of vasomotor or allergic etiology;
• polysinusitis, as well as sinusitis in the active or chronic phase;
• the process of preparation before performing manipulations or diagnostic procedures in the nasal cavity;
• preparation for surgery or postoperative elimination of swelling after a procedure in the nasal cavity.

Release form

The drug is produced in the form of nasal drops - inside 15 ml bottles. In addition, it is sold in the form of a spray - inside bottles equipped with a sprayer (volume 15 ml). It can also be produced in the form of a gel - inside a 12 g tube.

Pharmacodynamics

Phenylephrine is an amine sympathomimetic. It is used as a nasal decongestant with moderate vasoconstrictor effect, and in addition, it selectively stimulates the activity of α1-adrenergic endings within the venous cavernous tissues of the nasal mucosa. [ 2 ] As a result, swelling of the nasal mucosa with paranasal sinuses disappears quickly and for a long time. [ 3 ]

Dimethindene is a substance with an antagonistic effect on the H1-ends of histamine; it has antiallergic properties. It has an effect when administered in small doses and is tolerated without complications. [ 4 ]

Pharmacokinetics

In case of accidental oral administration of the drug, the bioavailability of phenylephrine decreases by about 38%. This is due to metabolic processes during the first intrahepatic and intestinal passage. The half-life is approximately 2.5 hours.

The systemic bioavailability of dimethindene after oral administration of solution is approximately 70%; the half-life is approximately 6 hours.

Dosing and administration

Drops LS for infants up to 12 months of age are administered 1 drop in each nostril, 3-4 times a day. At the age of 1-6 years - 1-2 drops, 3-4 times a day. For persons over 6 years of age, use 3-4 drops, 3-4 times a day.

The gel is injected deep into the nasal passage. The procedure is performed 3-4 times a day. It is prescribed only for persons over 6 years of age.

The spray is also used only for people aged 6 years and over. It is necessary to make 1-2 injections into each nostril, 3-4 times a day. The procedure should be performed holding the head vertically, taking shallow breaths after using the drug. The bottle is held with the spray upward, and the injection is made with light pressure.

The cycle duration is 1 week.

• Application for children

The medicine in the form of a spray and gel is not used by persons under 6 years of age.

Use Vibrocil during pregnancy

Vibrocil is prohibited for use during breastfeeding or pregnancy.

Contraindications

Among the contraindications:

• severe intolerance to the components of the drug;
• rhinitis that has an atrophic form;
• administration in combination with substances from the MAOI subcategory.

Side effects Vibrocil

Occasionally, the use of drugs leads to the occurrence of nasal dryness or burning.

Overdose

No severe manifestations were observed in cases of accidental oral administration of the drug by a child. Occasional abdominal pain, sleep disorders, severe fatigue, increased blood pressure, agitation, palpitations, and pale mucous membranes with epidermis appeared.

The medication has no antidote. Symptomatic actions are performed (taking laxatives and enterosorbents, as well as drinking large amounts of liquid).

Interactions with other drugs

The drug contains phenylephrine, which is why it is prohibited to combine it with MAOIs. In cases where the patient is already using MAOIs, the use of Vibrocil is allowed only after at least 2 weeks have passed since the last MAOI administration.

The drug should be used with caution in people taking tricyclics and antihypertensive drugs from the subcategory of beta-adrenergic receptor blockers.

Storage conditions

Vibrocil should be kept in a dark place, away from any heating devices. Temperature indicators - maximum 30°C.

Shelf life

Vibrocil can be used for a period of 36 months from the date of manufacture of the medicinal substance.

Analogues

An analogue of the drug is Grippocitron Rinos.

Reviews

Vibrocil receives generally good reviews from patients. It eliminates nasal congestion fairly quickly, has an anti-allergic effect and is convenient to use. The disadvantages include the short duration of the therapeutic effect and the high cost of the medication.