Veral

Veral is a medicinal product from the NSAID group of drugs.

Indications Verala

It is used locally for rheumatic pathologies of a degenerative or inflammatory nature:

• rheumatoid arthritis;
• JURA;
• arthritis of psoriatic origin;
• exacerbation of gout;
• dermatomyositis or polymyositis;
• polymyalgia of rheumatic nature;
• Libman-Sachs disease;
• Bechterew's disease;
• osteoarthritis.

In addition, the gel is prescribed for rheumatism of extra-articular origin (such as periarthritis humeroscapularis, as well as tendinitis, epicondylitis and tendosynovitis), pain in the spine, and in the treatment of postoperative or traumatic deformations affecting the motor system (dislocations, distortions or contusions).

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Release form

The substance is released in the form of a 1% gel, in tubes of 55 g, 1 piece per box.

Pharmacodynamics

An important element of the effect exerted by diclofenac is the slowing down of the processes of PG biosynthesis. Diclofenac suppresses the manifestations of inflammation (acute or chronic form), and also eliminates hyperemia and pain.

Topical use of diclofenac quickly leads to relief from pain and stiffness of joints in the morning, and in addition to this, it helps improve the mobility of the musculoskeletal system and reduces swelling. Thanks to this, it is possible to reduce the doses of NSAIDs and painkillers, which are prescribed for oral use simultaneously with the gel.

Pharmacokinetics

After local use, diclofenac passes well through the epidermis into the subcutaneous tissues, tendons, fascia, and also into the synovium and joint capsule. The component reaches effective indicators inside the inflamed tissues after 20 minutes, but inside the systemic bloodstream its values remain extremely low.

Diclofenac absorption after local application is 3.3%. This allows to exclude the development of most negative manifestations observed with parenteral or oral administration of the element.

Absorbed diclofenac is 99.7% synthesized in plasma with protein and undergoes first intrahepatic passage. After this, metabolic products are excreted in urine (40-65%) and feces (35%). Approximately 0.8-1% of the active component is excreted unchanged.

The distribution volume of the substance is quite low: within 0.12-0.55 l/kg. The level of total clearance is within 267-350 ml/minute.

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Dosing and administration

Most often, a strip of approximately 2-4 g of gel is applied to the affected area. The procedure is performed 3-4 times a day (0.4-0.8 m2 ⁾. The gel must be rubbed in for absorption into the epidermis.

The use of Veral gel can be combined with the introduction of other therapeutic forms of release containing diclofenac. The drug can be used for a long time.

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Use Verala during pregnancy

Considering that there is not enough information regarding the use of Veral gel in pregnant or breastfeeding women, it cannot be prescribed during these periods.

Contraindications

It is contraindicated for use by people with severe intolerance to any elements of the drug or drugs from the NSAID group. It is also prohibited to treat areas with wounds with the gel.

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Side effects Verala

Local side effects: sometimes contact dermatitis is observed, accompanied by itching, rash, burning sensation and redness of the epidermis.

General signs: negative effects on the gastrointestinal tract may develop, as well as manifestations of intolerance (Quincke's edema, asthmatic symptoms, etc.), which often develop when using drugs on large areas of the skin.

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Storage conditions

Veral should be kept in a dark place, out of reach of children. Temperature indicators should be within the range of 15-25°C.

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Shelf life

Veral can be used within 36 months from the date of manufacture of the pharmaceutical product.

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Application for children

The use of the gel in pediatrics (persons under 15 years of age) is prohibited.

Analogues

Analogues of the substance are Voltaren, Diclofenac, Diclac with Diclogen, and in addition Ortofen and Diclovit with Penseid, Dorosan, Flector and Naklofen.

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