Valusal

A yellowish or colorless gel intended for application to the skin, with a characteristic aroma. The active ingredient of this product is ketoprofen (a non-steroidal anti-inflammatory substance).

Indications Walusala

Inflammatory diseases of the joints and spine (systemic autoimmune arthritis, gout); degenerative-dystrophic diseases of the joint tissue, accompanied by pain and inflammation; inflammatory processes in the nerves and muscles; traumatic lesions of the joints, ligaments, tendons (sprains, dislocations, bruises); complex therapy of the lymph nodes and vessels, phlebitis.

Release form

The gel is packaged in aluminum tubes (30g and 50g), packed in cardboard boxes with instructions for use.

Pharmacodynamics

The active ingredient of the gel has a pronounced anti-inflammatory effect, due to which a decrease in pain syndrome is achieved. The action of the product is based on the suppression of the production of pro-inflammatory mediators - prostaglandins and leukotrienes by inhibiting the activity of cyclooxygenase types I and II. After applying the gel, lysosomal membranes are stabilized, vascular permeability is reduced, and microcirculation of blood and lymph at the site of inflammation is improved. This helps relieve swelling, pain, eliminates morning stiffness, and improves the patient's condition both during rest and during physical activity.

Pharmacokinetics

Serum concentration of the active component with repeated local use is almost a hundred times lower than with a single dose of 150 mg. Absorption of ketoprofen applied externally is slow, it practically does not accumulate in tissues (bioavailability does not exceed 5%). Metabolites of the active substance are acylglycuronides. Ketoprofen absorbed by the body's tissues is eliminated mainly by the kidneys. About 90% of the applied gel leaves the body per day.

Dosing and administration

Apply and lightly rub three to five centimeters of squeezed gel into the skin surface in places of inflammation twice or three times a day. The skin surface should be intact. The maximum dose is no more than 15 g/day, which corresponds to 28 cm of squeezed gel column. Treatment periods are short, depending on the specificity and severity of the pathology. It is prescribed by a specialist individually. The standard duration of therapy, as a rule, is from one to ten days.

The treated area does not need to be bandaged or covered with a dressing, since the preparation is well absorbed by the skin surface, it does not stain underwear and clothes. After treatment, it is recommended to wash your hands thoroughly, except when this is the place of application. In cases of long-term therapy, it is recommended to use rubber gloves.

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Use Walusala during pregnancy

In the first six months of pregnancy, ketoprofen can only be used if the expected benefit to the mother significantly outweighs the likelihood of harmful effects on the fetus.

In the last three months of pregnancy, ketoprofen, as a representative of substances that inhibit the production of prostaglandins, may pose a risk of cardiac and pulmonary complications for the fetus, as well as cause fetal intoxication. This substance may contribute to a decrease in blood clotting in the mother and child and activate bleeding during labor.

During lactation, Valusal-gel is contraindicated. If treatment is necessary for vital indications, breastfeeding should be stopped for this time.

Contraindications

Sensitization to the active substance of the gel, other non-steroidal anti-inflammatory drugs, aspirin triad. Photosensitivity in the anamnesis.

Recurrence of ulcerative lesions of the digestive organs; history of gastrointestinal hemorrhages, chronic digestive disorders (discomfort and pain in the epigastrium).

Violation of the integrity of the skin, exudates, rashes, infections, burns, acne. Do not use under hermetically sealed dressings.

Age group 0-15 years.

Side effects Walusala

Local effects

During treatment, allergies may be observed in the form of rashes (itchy erythema, eczematous, bullous lesions of the skin) or hyperemia, spreading over a larger area than the treatment area, rarely - they can cover the entire surface of the body.

After exposure to sunlight - itching and burning, dermatitis, malignant erythema multiforme, skin necrosis.

Avoid exposing the treated areas to ultraviolet radiation (natural and in a solarium) during the entire treatment period and for two weeks afterwards.

General effects

Long-term use and use of excessive amounts of gel may lead to:

• to dyspeptic disorders and gastrointestinal hemorrhages;
• cutaneous and respiratory manifestations of sensitization, anaphylaxis;
• weakness, drowsiness, migraine-like pain and dizziness;
• acute renal dysfunction, interstitial nephritis;
• due to the presence of ethanol, increased dryness and hyperemia of the skin may be observed;
• the ingredients of the gel may cause allergies, including delayed ones;
• Elderly people are at risk for the likelihood of side effects, however, there is no information that separate dosages are required at this age.

If side effects occur, stop using the gel and rinse the area thoroughly under running water.

Overdose

Local application virtually eliminates overdose due to the low bioavailability of the gel.

However, high doses distributed over a large surface can cause significant side effects. First aid - rinse the application site with running water.

Incorrect use of the gel or accidental ingestion may cause systemic effects (drowsiness, dyspepsia, dizziness, stomach pain, respiratory depression).

Large doses of the gel with prolonged application are associated with the risk of respiratory depression, comatose state, muscle spasms, gastrointestinal hemorrhages, hypertension or hypotension, as well as acute renal failure.

There is no specific antidote. Therapy is carried out according to symptoms. First aid, provided that no more than an hour has passed since the overdose: gastric lavage and activated carbon with sorbitol taken orally. In severe cases, an ambulance team is called immediately.

Interactions with other drugs

Since the plasma concentration is low when applied locally, the appearance of signs of interaction with other drugs is observed only in cases of frequent application on large surfaces:

• Possible intoxication with cyclosporine, methotrexate, lithium salts, cardiac glycosides as a result of their retention in the body;
• increasing the effectiveness of anticoagulants, aspirin and other non-steroidal anti-inflammatory drugs, glucocorticosteroids, phenytoin, hypoglycemic drugs;
• It is not recommended to use it in combination with other external agents that contain non-steroidal anti-inflammatory drugs;
• combination with blood pressure lowering drugs, diuretics, mifepristone weakens the effectiveness of these drugs (the interval between using Valusal and mifepristone should be at least eight days);
• combination with aspirin reduces the binding of ketoprofen to plasma albumins, with probenecid it helps to slow down the elimination of ketoprofen and reduce the level of its binding to serum proteins;
• Medical supervision is recommended for patients prescribed ketoprofen in combination with a coumarin.

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Storage conditions

Store at temperatures below 25°C. Keep out of reach of children.

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Shelf life

2 years.