Unilevel

Drug Uniliv belongs to the pharmacotherapeutic group of drugs used in diseases of the liver and biliary tract. Is hepatotropic agent.

Category of the medication drug Uniliv - without a prescription. 

Indications Unilevel

Unilev is used for both medical and preventive purposes:

• for the protection of the liver from exposure to toxic substances, including long-term use of various medications, poisoning with poisons or chemicals;
• in the complex therapy of cirrhosis and hepatitis;
• to alleviate liver condition in chronic alcoholics;
• for therapeutic and preventive effects in diseases of the gallbladder.

[1], [2], [3], [4]

Release form

The drug is available in tablet form. Tablets are semicircular, biconvex, have a protective shell of mustard shade.

The composition of the tablets is presented by the active and auxiliary ingredients:

• extract from milk thistle dry (30% silibinin A and B 150 mg), extract turmeric (10% curcumin 100 mg), extract dandelion (10% taraxasterol 75 mg);
• MCC, calcium hydrogen phosphate, magnesium stearate, sodium, stearic acid, silicon dioxide, dye, titanium dioxide, talc, and the like.

Blister pack contains 15 pcs. Tablets. A plastic bottle can contain 30, 60 or 120 pieces. Tablets. The blister or bottle is additionally packed in a cardboard box. 

[5], [6]

Pharmacodynamics

Unilev is a combined herbal remedy based on three types of medicinal plants: milk thistle, turmeric and dandelion.

The effect of milk thistle is explained by the properties of silymarin - a combination of powerful antioxidants, such as silibin, silichristin, silidianin. The main abilities of this plant:

• strengthening of cellular hepatic membranes;
• protection from the negative effects of intoxication, ethyl alcohol, free radicals;
• regeneration of affected liver cells, stimulation of phospholipid production;
• facilitating metabolic processes;
• prevention of fatty liver;
• blocking the development of the inflammatory process in the liver and the bile excretory system;
• stabilization of the formation and excretion of bile;
• detoxification of the liver.

 The action of curcumin is manifested by the following properties:

• choleretic;
• anti-inflammatory;
• lowers cholesterol.

 Dandelion also has a choleretic effect, due to the content of taracasterol in the plant. 

[7], [8], [9], [10], [11], [12], [13], [14], [15], [16]

Pharmacokinetics

The active substances of the drug interact with free radicals in the hepatic tissues and reduce their toxic effect. They also inhibit the process of cross-oxidation of fats, which can stop the destruction of hepatocytes. In the affected liver cells, the production of proteins and phospholipids is activated, the cell membranes are stabilized, the loss of basic cellular components and enzymes is blocked, the restoration of hepatocytes is accelerated.

Metabolism in the liver is a method of conjugation. The products of metabolism are derived through the system of bile secretion in the form of glucuronides and sulfates, and only a small part of them is excreted in the urine. Do not accumulate in the body.

[17], [18], [19], [20], [21], [22], [23]

Dosing and administration

Unilevel can be used for the treatment of adult patients and children, starting from the age of 12 years.

Oral tablets are taken during or immediately after meals. The standard scheme of treatment involves taking 1 tablet 1 to 2 times a day. The duration of the therapeutic course is not less than 90 days.

During treatment, you should follow a special diet, which is prescribed for liver diseases. Refusal to drink alcohol is mandatory, otherwise treatment will be impractical. 

[32]

Use Unilevel during pregnancy

Yunliv is not recommended for use in pregnancy and breastfeeding. Treatment Uniliv is possible only with a careful correlation of danger for the future child and benefits for the female body.

Contraindications

Like any drug, the drug Uniliv has certain contraindications to use:

• individual hypersensitivity to any of the ingredients of the medication;
• period of pregnancy;
• lactation period;
• children's age till 12 years;
• acute course or exacerbation of cholelithiasis or cholecystitis.

Before treatment, always consult a specialist and weigh all possible consequences. 

[24], [25], [26], [27]

Side effects Unilevel

Among the possible side effects can be identified as follows:

• irritation of the gastric mucosa;
• headache;
• itching;
• appetite disorder;
• increased gassing;
• heartburn;
• joint pain;
• allergic reactions;
• Dyspeptic phenomena (eg, diarrhea).

If you have any side effects, it is recommended that you consult a doctor. 

[28], [29], [30], [31]

Overdose

The cases of a drug overdose with Uniliv were not observed or described. Theoretically, it is possible to increase the side effects when using a large dosage of the drug. Treatment in this case is symptomatic.

[33], [34], [35], [36], [37], [38]

Interactions with other drugs

It is recommended to avoid the combined use of Uniliv and diuretics.

With simultaneous use of the drug and oral hormonal contraception, as well as other hormonal agents, their effectiveness may decrease.

Unilev is able to enhance the action of such drugs as Diazepam, Vinblastine, Ketoconazole, Alprazolam, Lovastatin.

Yunliv is incompatible with any alcoholic beverage or pharmacy tincture on alcohol.

[39], [40], [41], [42], [43], [44], [45]

Storage conditions

The drug should be stored at temperatures up to + 30 ° C. The storage location must be protected from children's access and darkened from sunlight. It is desirable to store the medicine in a sealed original package.

[46], [47], [48]

Shelf life

Shelf life of the drug - up to 3 years.

[49], [50], [51], [52], [53]