Medication Uniklofen, which is used in ophthalmic practice, refers to non-steroidal anti-inflammatory drugs based on diclofenac. It has the encoding ATC S01B C03.
Indications of the uniklofen
The eye preparation Uniklofen is used:
- to suppress the development of operative miosis during surgical intervention in patients with cataracts;
- for elimination of postoperative inflammatory reaction, which can develop after the operation of cataract removal, or on another occasion;
- to alleviate pain and discomfort in eye problems associated with the lesion of the epithelial layer of the cornea (for example, after mechanical damage or PRK);
- to facilitate the course of the inflammatory reaction after the procedure of argon laser trabeculoplasty;
- for relief of the condition with conjunctivitis of allergic nature;
- to eliminate inflammation and discomfort after surgery associated with correct strabismus;
- for the relief of soreness and elimination of unpleasant sensations after the operation of radial keratotomy.
The medication is available as a solution for instillation into the eye.
The active ingredient of the drug is sodium diclofenac. Among the auxiliary components are boric acid, sodium tetraborate, propylene glycol, hydroxypropyl betadex, edetate disodium, benzalkonium chloride.
Ophthalmic solution Uniklofen is a clear liquid, which sometimes can have a somewhat yellowish hue, without turbidity and impurities.
The drug is released in a special plastic dropper with a capacity of 5 ml. Packaging is a box of cardboard with an annotation liner inside.
Uniklofen acts due to the presence of diclofenac - a non-steroid substance with a bright anti-inflammatory and analgesic ability. The action of the solution is based on suppression of the biological synthesis of prostaglandins, which are of great importance in the development of an inflammatory reaction accompanied by pain.
Among the additional properties of Uniklofen are:
- prevention of pupillary narrowing during surgery;
- suppression of the inflammatory reaction in the postoperative period;
- relief of soreness and discomfort in trauma or ophthalmic procedures;
- prevention of puffiness after surgery;
- decrease in the phenomena of photophobia, burning, tingling, feelings of a foreign object in the eye.
Hydroxypropyl betadec - an auxiliary component - improves the dissolution of the drug in a water base and makes the drug more accessible to biological media and tissues.
Use of the uniklofen during pregnancy
Studies on the use of Uniklofen by pregnant patients have not been conducted.
Experiments with animals indicated an undesirable toxicity of the drug, which is especially evident in the third trimester. In this regard, we can assume the danger of early closure of the arterial duct and the possible inhibition of labor during labor.
In the first half of pregnancy, Uniklofen can be prescribed only for life indications.
The active ingredient is found in breast milk, but the negative effect of the drug on the baby is not proven. Nevertheless, it is desirable to avoid the use of a solution of Uniklofen during breastfeeding.
Side effects of the uniklofen
The most common side symptom when using Uniklofen is a temporary irritation of the eye mucous membranes.
In addition, other manifestations are possible:
- sensation of itching, redness of the eyelids, transient blurred vision;
- soreness in the eye;
- keratitis and corneal epithelium;
- allergic phenomena;
- difficulty breathing and exacerbation of bronchial asthma.
Dosing and administration
The drug Uniklofen is used to instill in the lower eyelid the eyes. The drug is never injected subconjunctivalally, or directly into the anterior eye chamber.
The dosage of Uniklofen may be as follows:
- to prevent operational miosis - drop by drop every 30 minutes for 2 hours before surgery;
- to control the inflammatory reaction after the operation - drop by drop four times a day, 14-28 days;
- to monitor the condition after PRK - drop by drop every half hour before surgery, drop by drop twice for 5 minutes immediately after PRK, drop by drop every 3-4 hours while awake during the day;
- for the control of a condition at a lesion of a corneal epithelium - on a drop 4 times a day, during 2 days;
- to control inflammation after ALT - drop by drop every half hour for 2 hours before ALT, after drop by drop 4 times a day for a week;
- to relieve the condition with allergic conjunctivitis - drop by drop 4 times a day;
- to ease the condition after surgery for strabismus - drop by drop 4 times a day (I week), three times a day (II week), twice a day (III week);
- to ease the condition after radial keratotomy - drop by drop before surgery, drop after operation, drop by drop 4 times a day for two days after the operation.