Ulter

Ultera is an antiulcer drug that is used for gastroesophageal reflux. Ultera is an inhibitor of the proton pump. It has the second name - pantoprazole (active medication).

Patients with severe hepatic impairment are used, since the level of hepatic enzymes can change their indications. Ulter's drug does not affect the functioning of the kidneys. 

Indications Ulter

The drug Ultera is prescribed for peptic ulcer of the stomach, also with ulcer of the duodenum. Gastroesophageal reflux disease is also treated with Ulter's drug.

Successfully applied in the treatment of Zollinger-Ellison syndrome, a stress ulcer.

Ultera is prescribed as part of a combination of anti-Helicobacter eradication therapy in those patients who have ulcers and in their bodies to reduce the frequency of relapses.  

[1], [2], [3]

Release form

The form of release of Ulter, which is available on the market - is a tablet. The drug is coated with an enteric film that has a yellow or orange color. The pills are round in shape, biconvex. Each tablet has a cross section - the core (white or cream colored). In some cases, the presence of marble is permissible.  

Available in the following forms - seven pieces in two blisters and in a cardboard bundle.

Also on ten pieces in strips and a cardboard bundle and on fourteen pieces in a strip. 

Pharmacodynamics

Ulter's pharmacodynamics is carried out in the following way: the active substance suppresses the action of hydrochloric acid in the stomach in that it specifically affects the proton pump of parietal cells. Pantoprazole is transformed into an active form in an acidic medium, which is most concentrated in the parietal cells of the stomach - that is, it is converted to hydrochloric acid. Suppression depends on the dose and can affect the stimulated appearance of secretions of juice in the stomach (an effect in which secretions are not produced throughout the day). Pantoprazole reduces the level of acid in the stomach and removes gastrin from the body.   

[4], [5], [6], [7], [8], [9], [10], [11]

Pharmacokinetics

The substance of pantoprazole is absorbed without residue after administration. When analyzed in blood plasma - the level of the drug reaches one μg / ml. It takes two hours to reach this level. This level does not increase even after prolonged use of the drug.

Bioavailability of the drug as enteric tablets is 75 - 80%. Binding to plasma proteins reaches almost 100%.

Pharmacokinetics Ultera conducts major metabolites through the kidneys. About 80% of the urine is excreted. The remaining twenty are removed with a chair.

But it must be taken into account that parietal cells do not correlate with pantoprazole.

[12], [13], [14], [15], [16], [17], [18], [19]

Dosing and administration

Ultera is taken orally. The tablet is not chewed and not divided, it must be swallowed whole and washed down with plenty of water. The time of application does not depend on the time of ingestion.

In the case of peptic ulcer disease, the dose should not exceed forty milligrams per day.
Elderly - no more than twenty milligrams a day.

In cases of duodenal ulcer treatment is two weeks, gastroesophage reflux - four weeks.

The course of treatment with the drug may be increased, depending on the individual characteristics of the disease. 

[35], [36], [37], [38], [39], [40]

Use Ulter during pregnancy

Use of Ulter during pregnancy is strictly prohibited. At the moment, there are no studies that confirm the absence of adverse effects on the fetus during pregnancy.

Also, during lactation and those who breast-feed - it is not recommended to take the drug. In extreme cases, either stop taking the medication or stop breastfeeding until the end of the complete course.

Contraindications

Strictly contraindicated Ulter's reception for dyspepsia of neurotic genesis. Contraindications to the use of Ulter extends to malignant diseases of the gastrointestinal tract. Pregnant and those who are in the period of lactation - also prohibited taking the drug.

In case of severe renal failure, it is necessary to limit or prohibit the use of Ulter, so metabolites can not be excreted from the body.

It is also contraindicated to apply Ultera to those who have an increased sensitivity to one of the constituents of the drug.
 

[20], [21], [22], [23], [24], [25], [26], [27]

Side effects Ulter

Various clinical studies have shown that the use of Ulter can lead to the following side effects:

• Digestive system - local pain sensations in the epigastric region, prolonged diarrhea, constipation, fits of flatulence, prolonged nausea, possible increased activity of hepatic enzymes.
• The central nervous system - headaches or migraines, there may be some visual impairment (blurring), drowsiness or insomnia, in extreme cases with prolonged admission - bouts of depression. Therefore, it is not recommended to receive those who spend a lot of time driving.
• Allergies are skin rashes that can itch, in rare cases anaphylactic shock is possible.
• There are rare cases of myalgia, edema, fever, elevated triglycerides.
   

[28], [29], [30], [31], [32], [33], [34]

Overdose

Conducted clinical studies have not detected cases of overdose with Ulter's drug. But in cases of increased side effects, it is necessary to carry out treatment that affects the elimination of symptoms. It should be borne in mind that dialysis will not work. 

[41]

Interactions with other drugs

When conducting clinical studies for the detection of negative interactions and subsequent elimination of effects, no negative or positive effect was found on the interaction of Ulter with other drugs. 

[42], [43], [44], [45], [46], [47], [48]

Storage conditions

The storage conditions for the medicinal product of Ulter should include a dry place, which will be protected from direct sunlight and various light sources. The temperature at which the drug should be stored should not exceed room temperature - 25 ° C.

The place you choose for storage must be protected from children and pets. 

Special instructions

Analogues

At the moment, the pharmaceutical market offers the following analogues of Ulter, which coincide by their medicinal purpose and active substance: Nolpasa, Proxium, Pulcet, Sanpras, Panum, Zipantola, Peptazol. 

[49], [50], [51]

Shelf life

The shelf life of Ulter's medication is two years from the date of manufacture. If the storage conditions are violated, this period is significantly reduced. It is strongly advised not to use the drug for treatment, after the expiration date. When withdrawing tablets from their factory stay environment (blisters), the shelf life of the drug is reduced. Before each use should check the date of manufacture, apply an expired product can be dangerous to your health.

[52]