Tsiprolet with cystitis

, medical expert
Last reviewed: 10.08.2022

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Inflammation of the bladder, as a rule, occurs due to the ingress of bacteria into it, therefore, antibacterial agents are used to treat it, including Ciprolet prescribed for cystitis.

Other trade names for this drug, that is, synonyms: Ciprofloxacin, Cipro, Cipriol, Ciprolac, C-phlox, Ciprinol, Cifran, Medociprin, etc. Etc.

Indications Tsiprolet with cystitis

Taking into account a fairly wide range of bactericidal effects of Ciprolet on aerobic gram-negative and gram-positive bacteria, indications for its use include infectious (bacterial) inflammation of the eyes, ENT organs and respiratory organs, the genitourinary system, intestines, abdominal organs and small pelvis, osteoarticular infectious diseases as well as bacteremia, bacteriuria and primary sepsis. [1]

Can Tsiprolet be used for cystitis? The expediency of using this antibacterial agent is determined by the attending physician - based on the results of a microbiological study (bakposev) of urine, which ensures the identification of the pathogen. Antimicrobial agents of the fluoroquinolone group of the II generation, which include the active substance of Tsiprolet - ciprofloxacin hydrochloride, are not used for the empirical treatment of cystitis, but are used when other antibiotics are not effective enough.

In addition, antibiotic therapy is not indicated for interstitial, drug-induced, radiation inflammation of the bladder, as well as cystitis that occurs with other diseases (diabetes, nephrolithiasis, spinal cord injury).

Read -  Antibiotics for cystitis . [2], [3]

Ciprolet for cystitis in women is prescribed under the same conditions, given that in almost 80% of cases of inflammation of the bladder and urinary tract are caused by bacteria from the intestines and lower urinary tract, since the female genital area often contains bacteria that can cause cystitis. Urologists refer to the causative agents of cystitis E. Coli - the bacterium Escherichia coli, as well as Enterobacter cloacae, Klebsiella spp., Proteus spp., Pseudomonas aeruginosa, Staphylococcus saprophyticus.

Release form

Tsiprolet is available in such forms as tablets (0.25 and 0.5 g each), solution for infusions (in 100 ml vials), eye drops (in 5 ml vials).


The active substance of the drug Ciprolet is a synthetic antibiotic of the second generation fluoroquinolone group ciprofloxacin (in the form of hydrochloride), which is a bicyclic fluorinated derivative of quinolinecarboxylic acid.

The basis of its pharmacological action, which leads to the death of pathogens (bactericidal effect), is the ability to specifically irreversibly suppress topoisomerase enzymes of bacterial cells (DNA topoisomerases II and IV), which ensure their DNA replication, protein synthesis and reproduction by division.


After oral administration of Ciprolet, ciprofloxacin hydrochloride is rapidly absorbed from the gastrointestinal tract and reaches peak plasma levels in one to one and a half hours. Binding to blood albumin does not exceed 30%, although the average level of bioavailability is 70%.

Ciprofloxacin hydrochloride droops into almost all tissues and body fluids, overcoming the blood-brain barrier; interstitial concentration is higher than in the blood, and remains at a high level for 10-12 hours.

The half-life in plasma lasts 3-5 hours; It is excreted from the body mainly by the kidneys (in unchanged form), as well as through the intestines.

Dosing and administration

How to take Ciprolet with cystitis? Cirolet tablets are taken orally before meals with water. A single dose of the drug is one tablet of 0.25 g. Two tablets are taken during the day (with an interval of 12 hours).

How much to drink Ciprolet with cystitis? The duration of the drug is determined by the doctor - according to the results of urine culture. The standard course of treatment is five to seven days.

  • Application for children

In connection with the existence of a threat of impaired development of articular cartilage tissue, fluoroquinolone antibacterial agents are contraindicated for children and adolescents under 18 years of age.

Use Tsiprolet with cystitis during pregnancy

It is not allowed to use antibiotics of the fluoroquinolone group during pregnancy and lactation, including Tsiprolet and its synonyms containing ciprofloxacin hydrochloride.


Tsiprolet for cystitis is not used if the patient's history includes:

  • individual hypersensitivity to fluoroquinolones;
  • convulsive syndrome;
  • disorders of cerebral circulation;
  • severe renal insufficiency and / or severe impairment of liver enzymes;
  • hemolytic anemia with deficiency of the enzyme glucose-6-phosphate dehydrogenase;
  • inflammation and dystrophic changes in tendons.

Side effects Tsiprolet with cystitis

The use of Ciprolet can cause side effects in the form of:

  • nausea, vomiting, abdominal pain, flatulence, and diarrhea;
  • headache, dizziness and increased intracranial pressure;
  • sleep disturbances, anxiety, general depression, tremor; decreased attention, visual acuity and hearing, as well as impaired taste and smell;
  • tachycardia and heart rate disorders;
  • skin itching and allergic skin rashes, hypersensitivity to ultraviolet radiation;
  • decrease in the level of leukocytes, granulocytes and platelets in the blood;
  • weakening and violation of the integrity of the tendons;
  • the appearance of blood, protein, calcium oxalate crystals in the urine;
  • urination disorders with damage to the renal glomeruli.


An overdose of Ciprolet leads to an increase in its gastrointestinal side effects, as well as to the appearance of convulsions and neurotic symptoms. There is no specific antidote; individual symptoms are treated.

Interactions with other drugs

In the instructions for Tsiprolet, the following interactions with other drugs are noted:

  • Tsiprolet is not taken simultaneously with antacids, Theophylline, Santuril (Probenecid), anti-tuberculosis antibiotic Rifampicin, selective immunosuppressant Cyclosporine, indirect anticoagulant Warfarin;
  • the simultaneous use of fluoroquinolones and drugs to lower blood sugar levels, as well as non-steroidal anti-inflammatory drugs (NSAIDs) slows down their elimination;
  • a combination of Ciprolet with antibiotics of the penicillin, aminoglycosides and cephalosporins groups is possible.

Storage conditions

Tsiprolet tablets should be stored in a dry place, away from light, at room temperature; solution - at a temperature not lower than +5°С and not higher than +25°С.

Shelf life

The drug is suitable for use within three years after release.

Tsiprolet analogues for cystitis

Pharmacotherapeutic action similar to Ciprolet, used in the treatment of inflammation of the bladder, is exerted by: antibiotics of the fluoroquinolone group, for example, Levofloxacin (Levoflox), Pefloxacin (Peflacin, Pinaflox), Lomefloxacin (Lomflox, Lofox, Okatsin); nalidixic acid preparations (Nevigramone, Negram); pipemidic acid preparations (Palin, Pimidel, Uropimide, Uripan, Uromidin).

Antimicrobials commonly used for bacterial cystitis are Nitrofurantoin (Furadonin), Co-trimoxazole, Fosfomycin (Fosmycin, Uronormin, Monural), the cephalosporin antibiotics Ceftriaxone, and Cephalexin.

What is better for cystitis, Tsiprolet or Nolicin?

Like Ciprolet, Nolicin (synonymous with Norfloxacin) is an antibiotic of the fluoroquinolone group, and has the same mechanism of action and pharmacodynamics. But the bioavailability of norfloxacin, as well as plasma protein binding, is almost half that of ciprofloxacin. In addition, the minimum single dose of Nolicin is higher than Tsiprolet (0.4 g versus 0.25 g). However, it is possible to take Nolicin for a longer period (up to two months) in patients with recurrent chronic cystitis.

Therefore, what is better for cystitis - Tsiprolet or Nolicin, is determined for each patient by a urologist.

The first FDA statements about the need to limit the use of antibacterial drugs belonging to the fluoroquinolone group due to serious side effects were made in 2016. And at the beginning of October 2018, having considered all the feedback from patients and doctors regarding the side effects of fluoroquinolone antibiotics, the experts of the European Medicines Agency came to the conclusion that it is necessary to introduce a restriction on their use.


To simplify the perception of information, this instruction for use of the drug "Tsiprolet with cystitis" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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