Teopek

Teopec is a purine derivative that slows down the activity of the PDE element.

Indications Teopeca

It is used for bronchial obstruction of various origins:

• sleep apnea;
• pulmonary emphysema;
• chronic obstructive bronchitis or bronchitis;
• pulmonary hypertension or pulmonary heart disease.

Teopec 0.3 g can be used in the treatment of edema syndrome of renal origin (in combination with other drugs).

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Release form

The drug is released in tablets, packaged in blister packs in quantities of 10 pieces. There are 5 such packs inside the box.

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Pharmacodynamics

The medicinal effect develops by blocking specific purine endings, and also by stimulating the processes of cAMP accumulation inside tissue depots. There is also a weakening of the contractile activity of smooth muscle tissues and a decrease in the amount of calcium ions penetrating through cell walls.

The drug has a vasodilatory effect, developing in relation to vessels of a peripheral nature. The active component potentiates the activity of renal blood circulation, and at the same time relaxes the smooth muscles of blood vessels and bronchi.

Teopec is characterized by moderate diuretic activity. The drug prevents the release and excretion of allergic reaction conductors and normalizes the function of the cell walls of labrocytes. In case of hypokalemia, the active substance of the drug potentiates pulmonary ventilation.

The drug stabilizes the function of the respiratory system, helping to fully saturate the blood with oxygen, while reducing carbon dioxide levels. In addition, stimulation of the respiratory center and contractile activity of the diaphragm (along with its strengthening) is noted. The drug increases the values of the MCC and helps improve the work of the respiratory and intercostal muscles.

The active component stabilizes microcirculation processes and reduces thrombus formation. In addition, it prevents platelet cell aggregation by inhibiting a specific factor, improves blood rheological characteristics and increases the resistance of red blood cells to deforming factors.

The medication reduces the overall pressure within the pulmonary circulation, and also reduces the resistance of the vessels within the pulmonary system and the tone of the vessels of the brain, epidermis and kidneys.

Teopec stimulates cardiac activity, potentiates coronary circulation processes, and in addition increases the pulse, the force of heart contractions and the need of myocardial cells to obtain oxygen.

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Pharmacokinetics

When the drug is taken orally, the active ingredient is completely absorbed from the lumen of the gastrointestinal tract. Food intake can change the clearance rates of theophylline and the rate of its absorption, but does not affect the degree of its expression. The level of synthesis with protein is 40%. Metabolic processes occur in the liver, with the help of cytochrome P450 isoenzymes.

Active metabolic products are excreted through the kidneys, and 10% of the substance is excreted unchanged.

The metabolic rate is influenced by some specific factors – the patient’s age, smoking, diet, concomitant diseases and parallel pharmaceutical treatment.

In cases of pulmonary edema, COPD, liver disease, chronic alcoholism or heart failure, a decrease in clearance values is observed.

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Dosing and administration

The treatment regimen is selected individually for each patient. The average size of the initial daily dose is 0.4 g. It is allowed to increase the dosage by 25% at 2-3-day intervals if the medicine is tolerated without complications (the calculation is performed starting from the initial dose mark).

A maximum of 0.9 g of theophylline may be administered per day (at dosages in this range, mandatory monitoring of blood levels of the substance is not required).

If any symptoms of poisoning develop, it is necessary to monitor the blood values of the active element. The optimal portion size ranges from 10-20 mcg/ml.

When the above dosage is increased, no significant potentiation of the medicinal effect is observed, but at the same time, potentiation of the severity of the negative signs of the drug is observed. Reducing the dose leads to a weakening of the medicinal effect.

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Use Teopeca during pregnancy

The active ingredient of Teopec is able to penetrate the placenta, which is why it can be prescribed to pregnant women only if there are vital indications.

It is necessary to stop breastfeeding during therapy, because the active component of the drug is excreted in breast milk.

Contraindications

Main contraindications:

• epilepsy;
• hemorrhagic form of stroke;
• ulcers in the gastrointestinal tract;
• tachyarrhythmias of severe severity;
• history of bleeding in the digestive system;
• the presence of intolerance to the components of the pharmaceutical product;
• increased or decreased blood pressure values;
• hyperacid gastritis.

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Side effects Teopeca

The use of the drug may provoke the occurrence of some side effects:

• lesions in the nervous system: tremors affecting the limbs, a feeling of irritability or increased anxiety, insomnia, dizziness, headaches and overexcitation of a nervous nature;
• dysfunction of the cardiovascular system: decreased blood pressure, arrhythmia, cardialgia, increased heart rate, sensation of severe interruptions in cardiac activity and an increase in the number of angina attacks;
• digestive disorders: gastralgia, nausea, loss of appetite, GERD, heartburn, diarrhea syndrome, exacerbation of ulcers inside the gastrointestinal tract and vomiting;
• other symptoms: pain inside the sternum, tachypnea, itching, hypoglycemia, a feeling of blood flow to the skin on the face, as well as a feverish state, allergic manifestations, hyperhidrosis, albuminuria, hematuria and potentiation of diuresis.

Reducing the dosage of the medicine helps to reduce the severity of negative symptoms.

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Overdose

Signs of intoxication: diarrhea, insomnia, arrhythmia of ventricular form, tachypnea, loss of appetite, tremor, as well as bleeding in the gastrointestinal tract, bloody vomiting, tachycardia, a feeling of overexcitation or anxiety, hyperemia of the epidermis, convulsions and photophobia.

Severe overdose may cause confusion, metabolic acidosis, decreased blood pressure, hyperglycemia, myoglobinuria, hypokalemia, renal failure, and epileptoid seizures.

To eliminate the disorders, it is necessary to perform gastric lavage and prescribe laxatives with enterosorbents to the patient. In addition, hemodialysis, hemosorption, forced diuresis and plasmasorption procedures are carried out.

If convulsions occur, oxygen therapy and intravenous administration of diazepam are required to stop the attack. In case of severe nausea with vomiting, metoclopramide with ondansetron is administered intravenously.

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Interactions with other drugs

Cimetidine, macrolides with lincomycin, as well as allopurinol with isoprenaline and oral contraception can reduce the clearance values of the theophylline component.

A weakening of the therapeutic effectiveness of β-adrenoblockers (when the drug is combined with them) is noted, as well as a weakening of the expression of the bronchodilator effect of the drug and a narrowing of the bronchial lumen. All the above characteristics are more noticeably expressed in non-selective β-adrenoblockers than in selective ones.

The effectiveness of theophylline increases with the use of caffeine, furosemide and drugs that stimulate the activity of β2-adrenergic receptors.

When aminoglutethimide is administered, potentiation of theophylline excretion is observed, as well as a loss of its medicinal effectiveness.

When combined with acyclovir, the severity of the negative symptoms of Teopec is potentiated, because the former increases blood levels of theophylline.

Diltiazem with felodipine and nifedipine with verapamil do not change the degree of expression of the bronchodilator effect of the drug, but can affect its plasma values. There is information about cases of potentiation of negative signs and increase in blood indicators of the active element when combining the drug with verapamil or nifedipine.

Disulfiram can increase blood theophylline levels to toxic, critical levels.

Propranolol reduces drug clearance rates.

Lithium salts lose their medicinal effectiveness when used together with Teopec.

The level of the active element of the drug increases with combined use with enoxacin or fluoroquinolones.

An increase in the clearance values of the drug and a decrease in the intensity of its therapeutic effect are observed when used in combination with sulfinpyrazone, rifampicin, and also with isoniazid, carbamazepine, and phenobarbital.

A mutual decrease in the indicators of active elements is recorded with a combination of theophylline and phenytoin.

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Storage conditions

Teopec should be kept in a place protected from moisture. Temperature values are within the 25°C mark.

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Shelf life

Teopec can be used within 24 months from the date of manufacture of the pharmaceutical product.

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Application for children

Teopec is a theophylline substance with a prolonged type of activity. It can be prescribed in pediatrics - to adolescents from 12 years old.

Analogues

Analogues of the drug are such drugs as Theotard with Euphyllin, as well as Theofedrin-N.

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Reviews

Teopec is a prolonged form of the element theophylline, so it is often used at the stage of remission of diseases of the respiratory respiratory system - to prevent the development of attacks. It is prohibited to use the drug in acute forms of attacks.

In general, both doctors and patients leave positive reviews about the drug.