Tenochek

Tenochek is a combination drug with antihypertensive properties.

Indications Tenochek

It is used to treat people with stable angina or high blood pressure.

Release form

The substance is released in tablets, packed in blister strips of 14 pieces. The box contains 2 such strips.

Pharmacodynamics

The active ingredients of the drug are atenolol and amlodipine. They mutually potentiate the medicinal effect and have complementarity.

Amlodipine has a powerful hypotensive and antianginal effect, weakening the tone of the smooth muscles of the vascular layer, and thereby reducing the total peripheral vascular resistance, and in addition, reduces blood pressure values. In addition, amlodipine reduces the need experienced by the heart muscle to obtain oxygen and stabilizes the energy balance inside the myocardial cells. Along with this, the substance helps to slightly expand the coronary vessels and improve blood circulation inside ischemic and healthy areas.

Atenolol is a β1-adrenoreceptor blocker; however, it does not have a membrane-stabilizing or internal sympathomimetic effect. The substance has a pronounced hypotensive effect, and at the same time, it has antianginal and antiarrhythmic properties that develop due to a decrease in heart rate. Atenolol reduces the need for the heart muscle to receive oxygen, reduces the number of angina attacks and helps improve the condition of the myocardium during hypoxia.

Dosing and administration

Tenochek is used for oral administration. It is prohibited to crush the tablets, but if necessary, they can be divided along the line. To obtain the maximum medicinal effect, the medicine should be taken before meals, at the same time of day. The drug is discontinued gradually, under the supervision of the attending physician. Withdrawal syndrome may develop if the use of the drug is stopped abruptly.

People with high blood pressure or angina are often prescribed 1 tablet per day.

People with kidney problems and CC values above 10 ml/minute are often prescribed 50% of the usual dose of the drug.

For those patients with renal dysfunction whose CC level is less than 10 ml/minute, it is recommended to take 25% of the usual dosage of the medication.

If necessary, the dose of Tenochek can be increased by the attending physician. During the first few weeks of therapy after increasing the dosage, it is necessary to monitor the patient's condition.

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Use Tenochek during pregnancy

Tenochek should not be used during lactation or pregnancy.

Contraindications

Main contraindications:

• use in people with intolerance to the components of the drug;
• significantly reduced blood pressure values;
• SSSU;
• AV block of 2nd or 3rd degree severity;
• acute heart failure;
• sinoatrial block;
• bradycardia;
• CHF at the compensation stage (stages 2-3);
• cardiogenic shock;
• severe peripheral blood flow disorders;
• diabetes mellitus;
• metabolic form of acidosis;
• chronic obstructive pulmonary pathology or bronchial asthma;
• psoriasis;
• severe kidney or liver dysfunction;
• cardiomegaly without symptoms of heart failure;
• spontaneous angina.

Caution is required when using in the following cases:

• First degree AV block;
• CHF at the compensation stage;
• aortic stenosis;
• pheochromocytoma;
• hyperthyroidism;
• state of depression (history or current);
• myasthenia;
• patients over 65 years old.

People who use contact lenses should take into account that when using Tenochek, tear production may be reduced.

Side effects Tenochek

The drug is fairly well tolerated. During treatment, the following side effects were noted in some patients:

• disorders in the cardiovascular system: problems with heart rhythm, decreased blood pressure, disturbances in AV conduction processes, signs of heart failure. In isolated cases, people suffering from angina experienced a worsening of their condition;
• problems with the functioning of the PNS or CNS: a feeling of severe fatigue, a feeling of cold along with tremors in the limbs, depression, dizziness, strange dreams, disruption of the daily routine, convulsions, and in addition to this, tinnitus, hallucinations, headaches, polyneuropathy and a feeling of weakness;
• gastrointestinal disorders: vomiting, dry mouth, taste bud dysfunction, nausea and bowel disorder. In addition, pancreatitis or hepatitis are also observed, or the bilirubin and liver enzyme levels increase;
• lesions affecting the respiratory system: dyspnea or bronchospasms;
• disorders of the endocrine system: gynecomastia, erectile dysfunction and decreased glucose tolerance;
• signs of allergy: urticaria, erythema multiforme, hyperemia, photosensitivity, itching and angioedema;
• Others: thrombocytopenia, decreased visual acuity, purpura, alopecia, antinuclear antibody formation, myalgia, hyperhidrosis, conjunctivitis and keratoconjunctivitis sicca. In addition, myasthenia gravis, gingival hyperplasia, vasculitis, joint pain and lipid metabolism disorder may be observed.

Overdose

When using excessively large doses of drugs, disturbances in heart rhythm or consciousness, bronchial spasms, nausea, and in addition to this, cyanosis of the fingers, dizziness and convulsions of a generalized nature are observed. Along with this, one can expect the appearance of reflex tachycardia or a significant decrease in blood pressure, reaching shock.

In case of poisoning or risk of shock, it is necessary to stop using the drug. If a strong drop in blood pressure is observed, it is necessary to carry out supportive procedures aimed at the work of the cardiovascular system.

Overdose of amlodipine and atenolol requires monitoring of respiratory function, cardiovascular system, diuresis and circulating blood volumes.

The attending physician may decide to prescribe parenteral administration of calcium gluconate, atropine (bolus intravenous injection in a portion of 0.5-2 ml), as well as glucagon (jet intravenous administration of 1-10 mg of the substance, and then through a dropper at a rate of 2-2.5 mg/hour), and in addition sympathomimetics.

If drug intolerance and severe bradycardia are observed, an ECS is prescribed temporarily.

If generalized seizures occur, diazepam is administered intravenously at a low rate.

Interactions with other drugs

The drug should not be combined with medications that inhibit ACE activity.

Parenterally administered Ca channel blockers, as well as other antiarrhythmic drugs, can be administered to people using Tenochek only in intensive care.

Anesthetic agents and antiarrhythmic agents when combined with the drug may potentiate the cardiodepressant effect of atenolol.

Combination with antidiabetic drugs may require a change in the dosage of insulin, as well as oral hypoglycemic drugs.

Concomitant use with clonidine, reserpine, and also guanfacine, SG and α-methyldopa leads to potentiation of the dromotropic, bathmotropic, and chronotropic effects of the drug.

The antihypertensive effect of atenolol is weakened when combined with sympathomimetics, xanthines, estrogens and non-narcotic analgesics.

Apresin, antacids, and nitroglycerin can reduce the absorption of atenolol when combined with the drug, while cimetidine inhibits the metabolic processes of atenolol.

Sympatholytics increase the medicinal activity of atenolol.

A potentiation of the effect of atenolol on the central nervous system is observed when Tenochek is combined with sedatives, neuroleptics, ethanol, sleeping pills and tricyclics.

Quinidine, inhalational anesthetics, calcium antagonists and amiodarone may enhance the effects of amlodipine.

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Storage conditions

The shade tree must be kept at temperatures around 25°C.

Shelf life

Tenochek can be used within 36 months from the date of manufacture of the pharmaceutical product.

Application for children

The drug is not used in pediatrics.