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Symptoms of lymphohistiocytosis
Medical expert of the article
Last reviewed: 04.07.2025
The initial symptoms of lymphohistiocytosis are numerous and nonspecific: fever accompanied by symptoms of gastrointestinal pathology or viral infection, progressive hepatosplenomegaly, lymphadenopathy, nonspecific rash, jaundice, edema, symptoms of CNS damage, and rarely hemorrhagic syndrome.
Thus, the following symptoms are practically obligatory: prolonged hectic fever with spontaneous regression in some patients, refractory to antibacterial therapy; rapidly increasing spleen, often in combination with an enlarged liver. All other manifestations are detected much less frequently, on average in a third of patients. Among them: transient maculopapular rash, widespread lymphadenopathy of moderate severity, in the absence of conglomerates and adhesion of lymph nodes to each other and surrounding tissues; neurological symptoms in the form of increased excitability, vomiting, convulsions, signs of intracranial hypertension and delayed psychomotor development.
Along with the tec, a small proportion of patients exhibit such formidable neuropathic symptoms as rigidity of the occipital muscles, opisthotonus, paresis and paralysis, acute loss of vision and consciousness. In isolated reports, there are data on lung damage, represented by interstitial changes.
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