Enelbin 100 retard

Enelbin 100 retard is a drug with peripheral vasodilating activity.

The component naftidrofuryl demonstrates a spasmolytic muscle-tropic effect on smooth arterial muscles, and at the same time weakens the tone of arterioles and the stability of peripheral vessels. The drug helps improve blood flow inside peripheral tissues, especially inside the central nervous system, and also weakens ischemic pain.

The medicine has a positive effect on brain activity – it normalizes sleep, reduces the frequency of headaches with dizziness and improves cognitive abilities.

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Indications Enelbin 100 retarda

It is used for disorders of peripheral blood flow, including trophic ulcers, intermittent claudication, Raynaud's disease, angiopathy of diabetic origin, paresthesia, acrocyanosis, cramps affecting the calf muscles, and pain that occurs in the limbs when at rest.

It is prescribed for disorders of blood flow within the brain (including insufficiency and atherosclerosis of a cerebral nature).

It can be used for behavioral disorders in the elderly, stroke or during recovery from it, post-comatose states or injuries, circulatory disorders in the inner ear, Meniere's morbus and damage to the eye function and retina of ischemic origin.

Release form

The component is released in tablets - 10 pieces in a cell plate; in a pack - 5 such plates.

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Pharmacodynamics

Naftidrofuryl is a specific blocker of the activity of S2-endings located inside platelets and smooth vascular muscles (antiplatelet effect and antiserotonergic vasodilation). Together with this, the component acts as an antagonist of bradykinin with nicotine.

Naftidrofuryl is a stimulator of energy exchange processes inside neurons and reduces the formation of algogenic elements (lactic acid). The substance activates the action of succinyl dehydrogenase inside tissues, helps to increase the volume of oxygen supplied to tissues, and also helps to remove glucose and increases the formation of ATP.

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Pharmacokinetics

Naftidrofuryl has good absorption in the digestive system. Prolonged release of the active element allows maintaining effective plasma indicators for at least 3-5 hours from the moment of drug administration. The component is 80% synthesized with intraplasmic protein.

Excretion in the form of metabolic elements is realized mainly with bile, and also with urine (to a lesser extent). The plasma half-life is approximately 40-60 minutes. The substance passes into mother's milk without complications and overcomes the BBB.

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Dosing and administration

The selection of the portion is carried out individually, taking into account the nature of the disease and its intensity.

In case of peripheral blood flow disorders, 0.1-0.2 g of the drug is usually used 2-3 times a day. The drug achieves its maximum effect when administered in a total daily dose of 0.4-0.6 g. The therapy lasts at least 3 months.

When treating conditions caused by disorders of intracerebral blood flow, it is necessary to take 0.1 g of the drug 3 times a day.

In case of ischemic stroke, 0.2 g of the substance is used 3 times a day, or 0.3-0.4 g 2 times a day.

The treatment should be long-term. The tablets are swallowed whole, without chewing, and washed down with plain water.

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Use Enelbin 100 retarda during pregnancy

There is no adequately confirmed information regarding the safety of using Enelbin 100 retard during pregnancy and breastfeeding. Therefore, during pregnancy it is used only in situations where the probable benefit from it is more expected than the risk of negative consequences for the fetus.

You should not breastfeed your baby during therapy.

Contraindications

Among the contraindications:

• severe intolerance caused by the action of naftidrofuryl or other components of the drug;
• recent acute myocardial infarction;
• Severe heart failure (NYHA class 3-4);
• TIA;
• severe disorders of nerve signal transmission;
• severe coronary insufficiency;
• conditions in which bleeding develops;
• history of vascular collapse;
• hyperoxaluria;
• a marked decrease in blood pressure values;
• disorders of orthostatic regulatory processes;
• recurrent calcium nephrolithiasis.

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Side effects Enelbin 100 retarda

In general, the medication is tolerated without complications, and sometimes the side effects that do occur are short-term and mild. Among them:

• disorders in the functioning of the cardiovascular system: orthostatic collapse, decreased blood pressure and heart rhythm disorders;
• problems affecting the function of the nervous system: anxiety and weakness, sleep disorders (eg, insomnia), increased fatigue, dizziness and headaches;
• gastrointestinal disorders: anorexia, gastric disorders, nausea, hepatopathy, pain in the epigastric region, vomiting, ulcers in the esophagus and diarrhea;
• disorders associated with the epidermis: itching, rash and signs of allergy;
• liver symptoms: liver disorders, including failure and hepatitis;
• disorders of the urinary tract and kidneys: formation of calcium oxalate stones inside the kidneys.

Overdose

Manifestations of overdose: usually develop spasms of central origin, confusion, cardiac conduction disorder, decreased blood pressure and increased signal transmission within the myocardium.

Symptomatic procedures are carried out, as well as procedures that support vital functions of the body.

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Interactions with other drugs

The combination of naftidrofuryl and antiarrhythmic agents or β-blockers leads to the development of a cardiodepressant effect and negative dromotropic activity, which can lead to the development of AV block.

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Storage conditions

Enelbin 100 retard should be stored in a place closed to children. Temperature indicators – no more than 25°С.

Shelf life

Enelbin 100 retard can be used within a 3-year period from the date of sale of the therapeutic substance.

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Application for children

The drug cannot be prescribed in pediatrics, because there is no information regarding the safety of its use and therapeutic effectiveness in this group of patients.

Analogues

Analogues of the drug are Naftidrofuril and Naftilux with Duzodrill.

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