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Causes of increased and decreased red blood cells

Medical expert of the article

Hematologist, oncohematologist
, medical expert
Last reviewed: 04.07.2025

Diseases and conditions accompanied by an increase in the number of red blood cells in the blood

Main pathogenetic groups

Clinical forms

Absolute erythrocytosis (increased production of red blood cells)

Primary

Secondary (symptomatic):

  • caused by hypoxia;
  • associated with increased production of erythropoietin
  • associated with excess corticosteroids or androgens in the body

Relative erythrocytosis

Mixed erythrocytosis due to blood thickening and placental transfusion

Erythremia

Lung disease, heart defects, presence of abnormal hemoglobin, increased physical activity, stay at high altitudes, obesity

Renal parenchymal cancer, hydronephrosis and polycystic kidney disease, liver parenchymal cancer, benign familial erythrocytosis

Cushing's syndrome.

Pheochromocytoma, hyperaldosteronism

Dehydration, emotional stress, alcoholism, smoking

Physiological erythrocytosis of newborns


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