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Pharmadol
Medical expert of the article
Last reviewed: 03.07.2025
Farmadol is a combination drug that has analgesic and anti-inflammatory properties.
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Pharmadol
Farmadol is indicated for use in the following cases:
- As a pain-relieving drug for the relief of mild to moderate pain;
- As an antipyretic for the treatment of diseases of any nature that are accompanied by a fever;
- To eliminate headaches or toothaches, migraines, rheumatic diseases, neuralgia, joint pain, primary dysmenorrhea.
Release form
It is produced in the form of tablets, 10 tablets on a blister pack, one package contains 3 blisters.
Pharmacodynamics
The antipyretic properties of acetylsalicylic acid are due to the fact that it affects the central nervous system, as it has the ability to suppress the process of PG-E2 synthesis in the hypothalamus - as a response to the influence of pyrogens. The analgesic effect of the substance develops centrally, and in addition to it, peripherally. The central is expressed in the effect of the substance on the centers of the hypothalamus, as well as a decrease in the pain threshold, while the peripheral is manifested as the ability to slow down the process of PG synthesis in inflamed areas, as well as prevent sensitization of pain endings in relation to mechanical or chemical irritants.
Paracetamol slows down the process of PG synthesis, thus providing an analgesic and antipyretic effect. This substance acts as a weak inhibitor of the biosynthesis of PG, which are involved in the inflammation process.
Caffeine is able to suppress the active functioning of the PDE enzyme, as a result of which cAMP accumulates. The main function of caffeine is active interaction with purine receptors located in the brain. Under the influence of caffeine, the analgesic properties of acetylsalicylic acid, as well as paracetamol, are enhanced, as a result of which the therapeutic effect occurs faster.
Dosing and administration
The medicine should be taken orally 2-3 times a day after meals: 1 tablet. No more than 6 tablets are allowed per day, dividing this dose into 3 separate doses. The duration of the treatment course should not exceed 1 week, and the specific figure depends on the severity of the disease.
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Use Pharmadol during pregnancy
It is contraindicated for pregnant women and breastfeeding women to use Farmadol.
Contraindications
It is prohibited to use Farmadol in case of gastric ulcer or duodenal ulcer, gastrointestinal bleeding, severe liver or kidney dysfunction, hypocoagulation, hypersensitivity to drug substances, G6PD deficiency and age under 14 years.
Side effects Pharmadol
The use of Farmadol can cause side effects that are typical for the substances included in the drug - paracetamol or aspirin: gastrointestinal bleeding, allergies, exacerbation of bronchial asthma, ulcerogenic, nephro- or hepatotoxic effects.
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Overdose
In case of severe overdose of the drug, a clinical situation develops that usually occurs in case of acute poisoning with salicylates or paracetamol: disturbances of consciousness with a possible state of coma, the onset of collapse, a state of dehydration, shortness of breath, increased body temperature, disorders in liver function, hyperventilation, and in addition, metabolic acidosis.
Overdose can be eliminated in the following ways: general detoxification of the body (gastric lavage, taking laxatives, as well as enterosorbents), infusion therapy to normalize the acid-base balance. If the patient has acidosis, it is necessary to administer a solution of E325 or baking soda. To reduce the hepatotoxic effect of paracetamol, cysteine, acetylcysteine or mercaptamine are used. Symptomatic treatment is also performed.
Interactions with other drugs
When Farmadol is taken in combination with anticoagulants, antiplatelet agents, and methotrexate (a sulfonylurea derivative), the effect of these substances is enhanced. The drug can also increase side effects from the use of glucocorticosteroids.
Farmadol should not be combined with salicylates and barbiturates, as well as rifampicin and anticonvulsants.
Storage conditions
Farmadol should be kept in a dry place, out of the reach of children and away from light. The room temperature should not exceed 25 degrees.
Shelf life
Farmadol is permitted to be used for 2 years from the date of manufacture of the drug.
Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Pharmadol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.