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Periosteal chondroma: causes, symptoms, diagnosis, treatment
Medical expert of the article
Last reviewed: 07.07.2025
Periosteal chondroma (synonym: juxtacortical chondroma) is a benign tumor consisting of mature cartilaginous structures and located in the cortical layer of bone under the periosteum.
The tumor accounts for only 0.66% of skeletal neoplasms and occurs in patients of various age groups.
Symptoms of periosteal chondroma correspond to those of enchondromas. A distinctive feature of a large neoplasm is a visually and palpably determined swelling in the area of the affected segment of the limb. Typical localization is the diaphyses and metadiaphyses of long tubular bones. Radiological and CT examinations reveal an eccentrically located (most often subperiosteally in the thickness of the cortical layer) focus of destruction with a surrounding zone of osteosclerosis. Periosteal reaction is not typical. Scintigraphy data are similar to those of enchondromas. Differential diagnostics include a metaphyseal fibrous defect and a primary chronic form of osteomyelitis.
Treatment of periosteal chondroma is surgical - marginal resection. In case of large tumor sizes, resection is supplemented by bone grafting of the defect.
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