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Panadol Extra
Last reviewed: 10.08.2022
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Panadol Extra is a combined drug that contains caffeine with paracetamol. The medication has analgesic and antipyretic properties.
Indications Panadol Extra
The drug is used to eliminate moderate or moderate intensity pain in patients (they can have different origins):
- headaches, as well as attacks of severe migraine or migraine-like pain;
- pain in muscles, joints, rheumatic, and also due to neuralgia;
- dysmenorrhea.
The medicine can also be used as an antipyretic during treatment of acute respiratory viral infection or influenza.
Pharmacodynamics
Paracetamol is an active component of the drug. It is included in the category of NSAIDs. Helps reduce the level of GHG in the central nervous system by suppressing the enzyme cyclooxygenase. The second active ingredient is caffeine. It helps strengthen the pharmacological effectiveness of paracetamol.
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Pharmacokinetics
After internal use, paracetamol is rapidly absorbed from the digestive tract. The peak concentration in the plasma reaches in 0.5-2 hours. The process of metabolism is carried out in the liver. The half-life is 1-4 hours, and excretion is usually carried out together with urine in the form of decay products.
Dosing and administration
Take the medicine you need inside. The tablet should be swallowed whole, without grinding or chewing, while washing with water. A drug like Solyubl needs to be dissolved in a glass with water before use. The duration of the treatment course, as well as the dosage should be selected individually - this is done by the doctor in charge.
For children from 12 years and adults, the dosage is usually 500-1000 mg of the drug (2 tablets) 3-4 times per day with an interval of at least 4 hours. Thus, a day can take no more than 4000 mg (or 8 tablets) of the drug.
To consume the drug for more than 3 days is allowed only with the appointment of the treating doctor.
During treatment with the use of Panadol Extra, it is not recommended in large quantities to drink beverages that contain caffeine.
Use Panadol Extra during pregnancy
Use Panadol Extra in pregnancy is allowed only if there is an urgent need.
Contraindications
Among the contraindications:
- individual intolerance to the components of the medication;
- severe degree of disorder in the liver or kidneys, congenital form of hyperbilirubinemia, as well as a deficiency in the body G6FD.
The drug can not be taken to patients with disorders in the hematopoietic system (such as leukopenia or severe anemia), thrombosis, elevated blood pressure, atherosclerosis, and thrombophlebitis. Do not appoint him and people suffering from alcoholism.
Do not use Panadol Extra in the treatment of patients with epilepsy, glaucoma (also with a closed-angle form), hyperthyroidism, and besides with cardiac conduction disorder, insomnia, decompensated heart failure, enlarged prostate, IHD, acute pancreatitis, and diabetes mellitus .
Contraindication is also the presence of a tendency to vascular spasms and a lactation period.
It is forbidden to use children under 12 years old and elderly patients.
Precautions are allowed for patients who have renal or hepatic pathologies.
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Side effects Panadol Extra
The medicine is mostly transferred without complications, but in some cases such adverse reactions can be observed:
- GIT: Severe vomiting along with nausea, pain in the epigastrium, and in addition to these symptoms, liver intoxication may develop or liver enzyme activity may increase;
- organs of the hematopoietic system: thrombocytopenia and pancytopenia, the development of anemia (in some cases, hemolytic), and in addition, sulfemoglobinemia or methemoglobinemia;
- organs of the central nervous system: problems with the regimen of the day (wakefulness and sleep), dizziness and severe irritability;
- organs of the cardiovascular system: tachyarrhythmia and increased blood pressure;
- allergy: itching on the skin, rashes, urticaria, exudative erythema multiforme, angioedema, anaphylaxis, and toxic epidermal necrolysis;
- Other: spasm of bronchial tubes, as well as hypoglycemia up to hypoglycemic coma.
Overdose
Owing to an overdose of the drug, its hepatotoxic and nephrotoxic properties may manifest, and in addition to this, symptoms of disorders in the functioning of the hematopoietic system (anemia and agranulocytosis, and in addition thrombocyto-, pancito-, neutro- and leukopenia), as well as CNS (tremor, problems with day regimen (wakefulness / sleep), increased excitability, dizziness). In addition, the patient may experience seizures, develop tachyarrhythmia, paleness of skin, glucose metabolism, vomiting, metabolic acidosis, and hepatonecrosis.
To eliminate symptoms, you should wash the patient's stomach, give him enterosorbents and conduct symptomatic treatment. In case of severe overdose, the patient is injected with N-acetylcysteine IV and given methionine (only if he does not have vomiting). When cramps occur, diazepam should be used.
Interactions with other drugs
It is forbidden to combine the drug with MAO inhibitors, β-adrenoreceptor blockers, and tricyclics. The interval between the course of treatment with Panadol Extra and the use of drugs from the category of MAO inhibitors should be at least 2 weeks.
In the case of drug combination with domperidone, as well as metoclopramide, the rate of absorption of paracetamol is increased. And when combined with cholestyramine - on the contrary decreases.
Due to the combination with warfarin and other anticoagulants of the coumarin series, the risk of bleeding increases.
As a result of simultaneous reception with barbiturates, the antipyretic properties of paracetamol are reduced.
Isoniazid, inducers of microsomal enzymes, and in addition hepatotoxic drugs increase the toxic effect of paracetamol on liver function.
In the case of the combination of Panadol Extra with diuretic drugs, the effectiveness of the latter is weakened.
It is forbidden to combine medicine with medications containing ethanol, and in addition to alcohol.
Caffeine contained in the drug enhances the properties of α- and β-adrenomimetics, and in addition to xanthine and drugs that have a simulating effect on the central nervous system.
Due to simultaneous use with oral contraceptives, cimetidine, and also isoniazid, the medicinal properties of caffeine are enhanced.
In combination with caffeine, the effect of drugs, suppressing the function of the central nervous system, is reduced.
Caffeine increases the concentration in the blood of lithium, increases the medicinal effect of thyrotropic drugs, and besides it increases the rate of absorption of ergotamine in the digestive tract.
Shelf life
Panadol Extra is allowed to be used within 4 years from the date of manufacture of the drug.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Panadol Extra" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.