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Nazofan
Last reviewed: 10.08.2022
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Nasophane is a topical nasal glucocorticoid with an external method of action.
Indications Nazofan
Indications for use are pollinosis (such as hay fever or allergic rhinitis) - the drug can be both curative and preventive.
Release form
Produced in the form of a nasal spray in flakonchikah for 120 or 150 doses. The pack contains 1 vial.
Pharmacodynamics
The active component of the drug - fluticasone - has anti-edema, as well as anti-inflammatory properties.
The anti-inflammatory effect is provided by suppressing the synthesis of cytokines and nitric oxide, and in addition to reducing the activity of genes responsible for the production of proteins and enzymes that provoke inflammatory processes.
The antiallergic effect is achieved by decreasing the sensitivity of the nerve endings with respect to the effect of histamine, as well as reducing the nonspecific hyperreactivity. The medicine helps to normalize the function of mast cells, and also prevents the release of inflammation conductors.
Fluticasone is related to receptors located on the nasal mucosa, it is able to inhibit the secretion secretion of the glands of the nasal cavity, and also removes edema, thereby facilitating breathing through the nose.
Pharmacokinetics
The medicine has a local effect, so the systemic absorption will be insignificant even if the spray is accidentally swallowed due to leakage through the nasopharynx. After intranasal administration of the drug in a daily dosage of 200 mcg, daily fluctuations in the cortisol substance do not change.
Fluticasone has a significant relationship with plasma proteins, and it binds to albumin up to an index of 91%. The metabolism of the substance occurs in the liver, where it is converted from fluticasone propionate to an inactive decay product of a carboxylic acid. Excretion occurs with bile.
Dosing and administration
Nasophane may only be used intranasally. Before the introduction of the first dose, you should press the nozzle 6 times, so that the medicine gets into the cavity of the nebulizer. If the spray is stored without use for more than 7 days, a new dose can be injected only after the nozzle has been pre-filled by several blanking strokes.
Adult patients, as well as children from 12 years of age, are prescribed 2 sprays per each nostril for the 1st time per day (the volume of the dose is 200 micrograms). It is advisable to conduct the procedure in the first half of the day. In rare situations, 2 procedures may be allowed per day with a break of 12 hours (the volume of the daily dose is 400 μg).
As a prophylaxis, a daily maintenance dosage of 100 μg-1 is used in each nostril once a day. At an exacerbation of disease the dosage should be increased up to medical. For a day it is allowed to take a maximum of 400 μg - 4 sprays per each nostril.
Children aged 4-12 years are recommended to do 1 spray in each of the nostrils once a day (100 mcg). In rare cases, it is possible to do 1 spraying per day with a break of 12 hours (a dosage of 200 μg is obtained). During the day, you can consume no more than 200 μg - in the amount of 2 sprays per each nostril. With a long course of treatment, the minimum permissible dosages are used. Regularity of procedures is required.
The treatment course with Nasophan spray usually lasts about 6 weeks.
Use Nazofan during pregnancy
Do not use Nazofan during periods of lactation, as well as pregnancy. The use is permissible only in cases when there is an urgent need.
Contraindications
Among the contraindications:
- individual intolerance of the active component or other elements of the drug;
- children's age is less than 4 years.
Side effects Nazofan
Occasionally, there may be adverse reactions, manifested as dryness or irritation of the mucous membranes inside the nasopharynx with the nasal cavity, and in addition perforation of the nasal septum, ulcerous defects on the skin or mucous membrane, bleeding from the nose, and the appearance of an unpleasant odor or taste.
There is the possibility of an anaphylactic reaction, and in addition to spasm of bronchi and edema in the nasopharynx - if there is individual sensitivity to the drug.
From the side of the central nervous system, the reaction can be manifested under the guise of headaches. Among other symptoms, there is an increase in the level of intraocular pressure, the development of cataracts or glaucoma - mainly due to prolonged use of the drug in large doses.
Interactions with other drugs
In the case of the combination of Nasofan with inhibitors of hemoproteins P450 (such as ritonavir), the level of fluticasone in the blood increases significantly, which increases the strength of its side reactions, which results in a powerful suppression of the adrenal function.
Erythromycin, and in addition to it, ketoconazole slightly increases the pharmacological activity of the active component of Nasophan, as a result of which the side effects of the drug are enhanced, but they still do not interfere with the function of the hypothalamus-pituitary adrenal system.
Storage conditions
Contain the spray is required in standard for medicines conditions, the temperature should not exceed 25 degrees.
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Shelf life
Nasophane is allowed to be used within 3 years from the date of manufacture of the spray. After opening the bottle - no more than 3 months.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Nazofan" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.