Medox

Medox is a drug from the mucolytic category.

Indications Medoxa

It is used to treat diseases affecting the respiratory system, against the background of which a cough is observed - to speed up the expectoration process. The medicine demonstrates effectiveness in diseases during which difficult to separate, highly viscous sputum appears.

The drug is prescribed for pneumonia, bronchitis, diseases accompanied by obstruction, asthma and bronchiectatic pathology.

Release form

The drug is released in tablets of 30 mg, packed in the amount of 10 pieces inside blister strips. One box contains 2 or 3 such strips.

It is also produced as a syrup, in 100 ml bottles (5 ml contains 15 mg of ambroxol). The pack contains 1 bottle of syrup and 1 measuring spoon.

[ 1 ], [ 2 ]

Pharmacodynamics

The active ingredient of the drug is ambroxol, which has a pronounced secretolytic and secretion-removing effect.

The medicine helps to excrete the secretion accumulated inside the bronchi, increasing the rate of mucolytic activity of the ciliated epithelium. In addition, it regulates the processes of sputum production inside the glandular cells.

Pharmacokinetics

Ambroxol is almost completely and at high speed absorbed in the gastrointestinal tract after taking the tablet orally. The bioavailability values of the substance are within 70-80%, and the protein synthesis indicators in the plasma are 75-90%. The Cmax level in the blood plasma is noted after 2 hours.

The drug quickly passes into tissues, especially into the kidneys and lungs. The half-life of ambroxol is within 10-12 hours. The drug is excreted with feces and urine (mainly in the form of non-toxic metabolic products). Approximately 90% of the consumed dose of the drug is excreted by the kidneys.

Ambroxol crosses the placenta and is also excreted in breast milk.

The drug clearance values may be reduced in people with severe forms of liver disease (by 20-40%). The half-life of the substance is extended in people with severe kidney disease.

Dosing and administration

The tablets are taken orally, it is recommended to do this after eating. For a child aged 6-12 years, the prescribed dosage is 0.5 tablet with 2-3 doses per day; for a teenager over 12 years old - 1 tablet 3 times per day. For an adult, the dose is 1 tablet 3 times per day or 2 tablets 2 times per day.

Before taking the syrup, shake the bottle with the substance to dissolve any honey sediment that may be present. The syrup is taken in portions measured out using a measuring spoon with divisions - 1.25 ml (¼), and 2.5 ml (½). The volume of a full measuring spoon is 5 ml of syrup.

The syrup is consumed in the following portions:

• children under 2 years of age – 2.5 ml 2 times a day;
• children 2-5 years old – 2.5 ml 3 times a day;
• children 5-12 years old – 5 ml 2-3 times a day;
• adolescents from 12 years of age and adults – 10 ml 3 times a day for 2-3 days, and starting from the 3-4th day – in a dosage of 5 ml, 3 times a day.

Therapy should last for 5-10 days.

The use of the medication in other dosage regimens is permitted only with a doctor's prescription.

Use Medoxa during pregnancy

It is prohibited to use Medox in the 1st trimester, and starting from the 4th month of pregnancy, the drug is used with caution.

It is prohibited to prescribe the drug to women during lactation.

Contraindications

It is contraindicated to use the drug in people with intolerance to its components.

Caution is required when prescribing to people with ulcers in the digestive organs, severe kidney diseases that impair their function, and liver failure.

The syrup is prescribed with caution in cases of hay fever or diabetes.

[ 3 ]

Side effects Medoxa

The use of the drug may cause nausea, dry mouth, increased fatigue, bowel disorders and headaches.

Sometimes the use of Medox leads to the appearance of dysuria, rhinorrhea or exanthema.

Occasionally, taking the drug causes side effects such as allergies in the form of urticaria, epidermal rashes, or anaphylaxis.

Dermatitis of an allergic nature may occasionally occur when using the medication.

[ 4 ]

Overdose

In case of drug intoxication, hypersalivation, vomiting, hypotension, and diarrhea develop.

Interactions with other drugs

The medicinal effectiveness of the drug is weakened when combined with drugs that suppress the cough reflex, because they interfere with the discharge of sputum.

The medicinal activity of amoxicillin, doxycycline and erythromycin with cefuroxime is potentiated when combined with Medox due to an increase in the amount of these substances passing into the bronchial secretion.

[ 5 ]

Storage conditions

Medox should be kept in a dark and dry place, out of reach of small children. The temperature level should not exceed +25°C. An opened bottle of syrup has a shelf life of 0.5 years when kept at a maximum temperature of 25°C.

Shelf life

Medox can be used within 24 months from the date of manufacture of the medicinal product.

Application for children

The tablets should not be used in pediatrics – for children under 6 years of age.

[ 6 ]

Analogues

The drug's analogues are Bronkhoksol, Ambrosan, Hydrocortisone and Bronchoval with Mucaltin, as well as Sulfocamphocaine, Terpon, Libexin, Doxycycline and Doctor MOM. The list also includes Fervex, Erythromycin, Dexamethasone, Sulfadimezine with Flucloxacillin, Sulfazine with Kitazycin, Potesept, Oleandomycin phosphate, Amizon, Sulfadimethoxine and Metronidazole with Sulfapyridazine.