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Magne-B6 +
Medical expert of the article
Last reviewed: 03.07.2025
ATC classification
Active ingredients
Pharmacological group
Pharmachologic effect
Indications Magne-B6 +
This drug is prescribed in cases of magnesium and vitamin B6 deficiency, which may occur due to nutritional disorders (due to diets), chronic alcoholism, due to prolonged stress and excessive physical and mental stress, with prolonged use of diuretics, during pregnancy.
The presence of magnesium and vitamin B6 deficiency may manifest itself as: increased fatigue and irritability; depression and sleep disorders; circulatory disorders and increased heart rate; gastrointestinal spasms and constipation; muscle weakness, myalgia, paresthesia and cramps of skeletal muscles; joint pain.
Clinical practice shows the effectiveness of Magne-B6 + in the complex therapy of heart failure, angina pectoris, atherosclerosis, arterial hypertension, diabetes mellitus, osteoporosis, and depression.
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Pharmacodynamics
Magnesium is an intracellular cation; up to 65% of its reserves are in bones, about 30% in other tissues, and the rest in extracellular fluid. A third of magnesium is bound to proteins, and there are at least 700 such proteins in the body.
Magnesium takes an active part in metabolism, primarily as a coenzyme for the synthesis of nucleic acids, proteins and energy metabolism. Penetrating through cell membranes, this microelement promotes the integrity of cell membranes of tissues of almost all internal human organs, restores the resting potential of muscle cell membranes, reduces the degree of neuronal excitability and regulates the transmission of nerve impulses. Magnesium is needed to ensure the norm of platelets in the blood, the synthesis of serotonin, unsaturated fatty acids and porphyrins.
Pyridoxine in Magne-B6+, when entering the body, is converted into the coenzyme form of pyridoxal phosphate, which takes direct and indirect part in protein, fat and carbohydrate metabolism; in the synthesis of red blood cells; in ensuring the sodium-potassium balance in the body's fluids, as well as in supplying glucose to nerve cells.
Pharmacokinetics
Due to the presence of pyridoxine hydrochloride (vitamin B6) in the preparation Magne-B6 +, the level of absorption of magnesium lactate dihydrate from the small intestine is significantly increased (up to 45% of the dose taken) and its penetration into tissue cells and intracellular space is facilitated. At the same time, vitamin B6 reduces the excretion of magnesium from the body.
Magnesium undergoes glomerular filtration in the kidneys, and almost a third of it is excreted in the urine.
Dosing and administration
Magne-B6 + is prescribed to be taken orally - during meals, with 200 ml of water. The daily dose for adults is 6 to 8 tablets, which are taken in two or three doses. For children over 6 years old, the permissible daily dose is 4-6 tablets. The duration of the course of treatment is a month.
Use Magne-B6 + during pregnancy
The use of Magne-B6 + during pregnancy requires strict recommendations from the attending physician and is prescribed to pregnant women in case of increased uterine tone, muscle cramps in the legs, and also to prevent the development of late toxicosis (preeclampsia). Treatment should be carried out under constant medical supervision.
Contraindications
Contraindications to the use of this drug are: moderate and severe renal failure, hereditary disorder of amino acid metabolism (phenylketonuria), impaired absorption of glucose or galactose, hypersensitivity to the components of the drug, children under 6 years of age.
Magne-B6 + should be prescribed with caution in case of calcium deficiency in the body, diabetes mellitus, gastric ulcer and duodenal ulcer.
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Side effects Magne-B6 +
Side effects of Magne-B6 + may include pain in the epigastric region, constipation, nausea, vomiting and flatulence. On individual ingredients in the composition of the drug.
An allergic reaction may occur - skin rash and itching.
In addition, magnesium affects the absorption of iron, which can cause symptoms of iron deficiency anemia.
Overdose
An overdose of this drug is possible only if the patient has impaired renal function. In this case, nausea and vomiting, a drop in blood pressure, and difficulty breathing are observed. The possibility of a comatose state and cardiac arrest cannot be ruled out. Overdose is treated by rehydration and forced diuresis, and in case of renal dysfunction - hemodialysis.
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Interactions with other drugs
When prescribing Magne-B6 +, its interactions with other drugs should be taken into account. It is not recommended to use Magne-B6 together with phosphates and calcium compounds, as this reduces the absorption of magnesium in the gastrointestinal tract.
In turn, magnesium reduces the effect of tetracycline antibiotics, thrombolytic drugs and some drugs against Parkinson's disease.
Pyridoxine, which is part of Magne B6, enhances the effect of diuretics and cardiac glycosides.
Shelf life
The shelf life of the drug is 24 months.
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Manufacturer
Attention!
To simplify the perception of information, this instruction for use of the drug "Magne-B6 +" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.