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Kalpol
Last reviewed: 23.04.2024
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Kalpol is an oral suspension for children. It has a strawberry smell and a pink color. The main properties of the medicine are analgesic and antipyretic.
Indications Kalpol
It is indicated for children from 3 months. (at an earlier age the medicine can be prescribed only by a doctor) up to 6 years. It is used as an antipyretic drug (for diseases such as influenza, ARVI, various childhood infectious processes, as well as reactions to vaccines and other conditions in which there is an increase in temperature), and in addition, an analgesic drug (mild or moderate pain syndrome (dental or headache, as well as muscular pain, neuralgia, as well as painful sensations due to burns and various injuries and injuries)).
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Release form
It is produced in the form of a suspension in glass bottles with a volume of 70 or 100 ml. One package contains 1 bottle, as well as a measuring spoon.
[2]
Pharmacokinetics
After oral administration, the peak concentration in the blood plasma is observed after 0.5-1.5 hours. The ratio of bioavailability, as well as the distribution of the active component in infants and children is similar to that in adults. The half-life is approximately 1.5-2.5 h.
The process of metabolism occurs in the liver. In patients under 10 years of age, the main degradation product is paracetamol sulfate, while at the age of 12+ years it is direct glucuronide. In the case of a deficiency of glutathione, these metabolites are able to block enzyme hepatocyte systems, provoking necrosis. Then about 85-95% of the drug is excreted along with the urine for 24 hours (less than 4% of the dose - unchanged).
Dosing and administration
To drink orally, washed down with water, 1-2 hours after eating, 3-4 r. / Day. The interval between receptions should be at least 4 hours. Do not use water to dilute the suspension. To dose the mixture was more convenient and accurate, a measuring spoon is used (marks 2,5, as well as 5 ml are indicated).
Single-use dosages for infants at the age of 3 months / 1 year - 2.5-5 milliliters of suspension (60-120 milligrams of paracetamol). At the age of 1-6 years - 5-10 milliliters of medication (120-240 milligrams of paracetamol).
The treatment course usually lasts 3 days (if the medicine is used as an antipyretic) or 5 days (if the medicine is used as an anesthetic). If it is necessary to prolong the course, you should consult your doctor.
Side effects Kalpol
Among the adverse reactions: vomiting with nausea, allergies (such manifestations as itching and rash on the skin, angioedema and urticaria), pain in the abdomen. In rare cases, develops leukopenia, thrombocytopenia or neutropenia, as well as anemia. In the case of long-term admission in large doses, nephrotoxic and hepatotoxic effects may occur, as well as methemoglobinemia or panmyelophthisis.
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Overdose
Signs of an overdose: increased sweating, severe pallor, pain in the stomach, and besides this vomiting with nausea. After 1-2 days. Symptoms of the disorder start to appear in the liver (there are pain sensations in this area, and the activity of liver enzymes in the blood increases, the PTV increases). In severe overdose, hepatonecrosis and hepatic failure are observed, and in addition to this, encephalopathy and confluence in coma.
As a therapy: you need to cancel the medication, perform gastric lavage, drink enterosorbents (such as polyphepan, and also activated charcoal) and inject into / into a special antidote N-acetylcysteine (or you can prescribe oral methionine intake).
Interactions with other drugs
Alcoholic beverages, tricyclics, barbiturates, antiepileptic drugs, and in addition rifampicin and phenylbutazone increase the hepatotoxicity of Kalpola, and salicylates - its nephrotoxic effect.
Paracetamol is also capable of increasing the properties of indirect anticoagulants, and in addition to weakening the effect of uricosuric agents and increasing the toxicity of chloramphenicol.
Storage conditions
Keep the medicine in a place that is closed from children and sunlight. Temperature conditions - no more than 25 ° C.
[19]
Shelf life
Kalpol it is authorized to use within 3th years from the moment of manufacturing of a medicine.
[20]
Attention!
To simplify the perception of information, this instruction for use of the drug "Kalpol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.