Immunoreactive trypsin in the blood of newborns (test for congenital cystic fibrosis)

Cystic fibrosis (cystic fibrosis) is a fairly common disease. Cystic fibrosis is inherited by autosomal recessive type, it is detected in 1 of 1500-2500 newborns. Due to early diagnosis and effective treatment, the disease is no longer considered to be inherent only in childhood and adolescence. With the improvement of methods of treatment and diagnosis, an increasing number of patients reach adulthood. Currently, 50% of patients survive to 25 years. The main method of early postnatal diagnosis of cystic fibrosis is the determination of the concentration of trypsin in the serum of newborns.

Reference values (norm) of concentration of immunoreactive trypsin in blood serum

Age	Immunoreactive trypsin, μg / l
Blood from the umbilical cord	23.3 ± 1.9
0-6 months	31.3 ± 5.4
6-12 months	37.1 ± 6.9
1-3 years	29.8 ± 1.8
3-5 years	28.3 ± 3.2
5-7 years	35.7 ± 3.6
7-10 years old	34.9 ± 2.2
Adults	33.3 ± 11.1

An increase in the concentration of trypsin in the blood serum of children in the first few weeks after birth indicates the presence of cystic fibrosis, and therefore the definition of this indicator is considered an effective screening method. With the progression of the disease and the development of true pancreatic insufficiency, the concentration of trypsin in the blood serum decreases.

[1], [2], [3], [4], [5], [6], [7], [8], [9]