Hypromelose-P

Hypromellose-P (hydroxypropyl methylcellulose) is a substance widely used in the pharmaceutical and food industries. It is a type of cellulose modified by the addition of hydroxypropyl groups. Hypromellose-P has a number of useful properties that make it useful for use in drugs and food additives:

1. Viscosity regulation: Hypromellose-P provides control over the viscosity of solutions, which allows it to be used as a stabilizer and thickener.
2. Film Formation: This substance can form strong and stable films on the surface of tablets, capsules and other dosage forms, which provides them with protection from moisture and improves their resistance to destruction.
3. Degradability: Hypromellose-P can be modified to control the rate of its degradation in the stomach, which is useful for controlled drug release.
4. Bioavailability: The use of hypromellose-P may improve the bioavailability of some drugs.
5. Safety: This substance is generally considered safe for consumption as it does not contain any toxic components and is well tolerated by the body.

Hypromellose-P is often used as an ingredient to create various dosage forms such as tablets, capsules, eye drops, nasal sprays and others. It can also be used in the food industry as a thickener, stabilizer and emulsifier.

Indications Hypromellose-P

1. Dry eye syndrome: This drugHypromellose-P can be used in ophthalmology to create eye drops or gels designed to moisturize and protect the cornea. These drops are usually available as a solution or gel in special bottles or packages for single use. The exact release form and method of administration may vary depending on the specific drug and its instructions for use. ts: Using eye drops with hypromellose-P can also help maintain the health of the cornea by keeping it moisturized and protected from harmful effects.

Release form

Hypromellose-P can be used in ophthalmology to create eye drops or gels designed to moisturize and protect the cornea. These drops are usually available as a solution or gel in special bottles or packages for single use. The exact release form and method of administration may vary depending on the specific drug and its instructions for use.

Pharmacodynamics

1. Moisturizing: Hypromellose-P has good moisturizing properties. When applied as eye drops, it forms a protective film on the surface of the cornea, preventing moisture evaporation and maintaining its moisture.
2. Protection from injury and irritants: Hypromellose-P may help protect the cornea from external irritants such as wind, dust or pollution, preventing them from entering the eye and minimizing the risk of injury.
3. Improved Comfort: Use of hypromellose-P may improve eye comfort and reduce the sensation of dryness, burning, or gritty sensation in the eyes that often accompanies dry eye syndrome.
4. Contact Lens Compatibility: Hypromellose-P-based formulations are generally compatible with contact lenses, making them useful for corneal hydration and protection in contact lens wearers.

Pharmacokinetics

1. Absorption: Hypromellose-P may help increase the contact time of the active ingredient with the corneal surface, which may promote its better absorption and penetration.
2. Distribution: The product is usually distributed over the corneal surface, providing long-lasting hydration and protection.
3. Metabolism and excretion: Hypromellose-P is not generally metabolized or excreted from the body, but rather is washed out of the ocular surface along with the drug.

Dosing and administration

The method of administration and dosage of hypromellose-P in the preparation for moisturizing and protecting the cornea may be specified in the instructions for the preparation or the doctor's recommendations. Usually, eye drops or gels with hypromellose-P are applied to the conjunctiva of the eye in accordance with an individual prescription or the manufacturer's recommendations.

Use Hypromellose-P during pregnancy

The use of Hypromellose-P (hydroxypropyl methylcellulose) as a corneal moisturizer and protector during pregnancy is generally considered safe because the substance is not usually absorbed into the bloodstream or crosses the placenta.

Contraindications

1. Known allergy or intolerance: People with a known allergy to hypromellose-P or any other component of this product should avoid using it.
2. Pregnancy and breast-feeding: If you are pregnant or breast-feeding, consult your doctor before using any eye medication, including those containing hypromellose-P.
3. Paediatric population: Hypromellose-P containing eye preparations may be used in children, but dosage and administration regimen may vary depending on age. It is recommended to consult a doctor.
4. Hypersensitivity to ophthalmic drugs: People with hypersensitivity to ophthalmic drugs or with a history of allergic reactions to them should use the drug with caution or consult a doctor.
5. Corneal damage or other serious eye conditions: In some cases, hypromellose-P products may be contraindicated in the presence of serious eye conditions or corneal damage. A doctor should decide whether the product is appropriate in a particular situation.
6. Not recommended for use with contact lenses: In some cases, hypromellose-P products may contain preservatives or other ingredients that may adversely affect contact lenses. It is recommended to remove contact lenses before use and put them back on only after thoroughly rinsing the eyes with water or special drops.

Side effects Hypromellose-P

In general, Hypromellose-P is well tolerated by most users, but like any other drug, it may cause side effects in some people:

1. Eye irritation:

   • Some users may experience temporary eye irritation immediately after applying the drops. This may include burning, itching, or redness of the eyes.

2. Blurred vision:

   • After using the drops, temporary blurred vision may occur. This usually goes away quickly, but if it persists, you should consult a doctor.

3. Allergic reactions:

   • Although rare, allergic reactions to the components of the drops are possible. Symptoms may include severe irritation, swelling of the eyelids, soreness, or even more serious manifestations such as swelling of the face or difficulty breathing.

Overdose

Overdose of hypromellose-P based corneal moisturizer and protector is unlikely due to its safety profile. Hypromellose-P used in ophthalmology usually does not affect the body as a whole, but affects the eyes directly.

However, if the drug is accidentally swallowed, some unwanted symptoms may occur, such as mild irritation in the throat or stomach. These symptoms are usually minor and resolve on their own.

If you experience any discomfort after accidentally swallowing the drug, it is recommended to rinse your mouth with water and consult a doctor or toxicologist to assess the situation and receive recommendations for further action.

Interactions with other drugs

Hypromellose-P, used in the preparation for corneal moisturizing and protection, does not usually interact with other ophthalmic medications or systemic drugs. Such topical agents usually do not exhibit systemic effects and do not have systemic effects, which minimizes the possibility of interactions with other drugs.