Helpex

Helplex is a medicine from the pharmacological group of anti-inflammatory analgesics. Consider its main properties, indications for use and other features of use.

An anesthetic combined preparation from the group of antipyretic, nonsteroidal antirheumatic drugs, is used to treat acute respiratory viral infections. The drug has anti-tussive, antipyretic, anti-inflammatory, anti-allergic and analgesic properties.

The drug has several release forms that are suitable for patients of all ages. The composition of the medicament includes several active components that have a strong therapeutic effect. These are paracetamol, phenylephrine, caffeine, menthol, chlorpheniramine, cetirizine and others. It is released without a prescription, but before using it is worth consulting with a doctor.

Indications Helpex

Pharmacological group of the drug indicates its anti-inflammatory, antipyretic and antirheumatic properties. Consider the indications for the use of Helpex:

• Acute upper respiratory tract infections
• Symptomatic therapy of influenza and ARVI
• Colds accompanied by dry cough and fever
• Allergic rhinitis

The drug perfectly helps with the first symptoms of influenza or acute respiratory viral infection. Since the medicine contains several active ingredients, it perfectly removes headaches, malaises, nasal congestion and other signs of a cold.

Release form

The pharmaceutical agent has several forms of release, which makes its use affordable for patients of different age categories. Let's consider the basic kinds of a preparation, the form of release and structure:

• Helpex Anticold

Tablets for oral use, are available in packs of 4, 10, 80 and 100 tablets. Active ingredients: paracetamol, caffeine, chlorpheniramine maleate and phenylephrine hydrochloride.

• Helpex Anticold DX

Tablets for oral administration, are sold in a package of 4, 10, 80 and 100 tablets. Active components: paracetamol, dextromethorphan hydrobromide, caffeine, phenylephrine hydrochloride, chlorpheniramine maleate.

• Helpex Anticold syrup

The medication is available in 60 and 100 ml vials. Each bottle contains: menthol, chlorpheniramine maleate, bromhexine hydrochloride, dextromethorphan hydrobromide and phenylephrine hydrochloride.

• Helpex Hot Cap

Powder for solution for oral administration. Produced with lemon and raspberry flavor in bags of 5 g. Active substances: paracetamol, cetirizine hydrochloride and phenylephrine hydrochloride.

Helpex antikold

An effective combined remedy for eliminating the symptoms of acute respiratory viral infection and influenza is Helpex antikold. The medicine has analgesic, antitussive, antipyretic, anti-inflammatory and anti-allergic properties. Removes symptoms such as: rhinitis, nasal congestion, headaches, sneezing. Application at the first sign of a cold, significantly improves overall well-being and helps the immune system to fight viruses.

Since the tablets contain several active components, consider the action of each of them:

• Paracetamol - has antipyretic, anti-inflammatory and analgesic effect. This therapeutic effect is associated with the effect of the medication on the thermoregulatory center located in the hypothalamus.
• Phenylephrine hydrochloride - has vasoconstrictive effect, reduces edema of the nasal mucosa.
• Caffeine - stimulates the central nervous system, affects the vasomotor and respiratory centers.
• Dextromethorphan hydrobromide - has antitussive properties, reduces the sensitivity of receptors and raises the threshold of sensitivity of the respiratory tract in relation to various stimuli.
• Chlorpheniramine maleate - eliminates itching in the nose and lacrimation, has anti-allergic properties.

The medication is allowed for patients over 12 years of age. Dosage and duration of therapy are selected by the doctor. As a rule, take 1 tablet 3-4 times a day, the interval between doses should be 4 hours. The duration of treatment should not exceed 5 days.

Contraindicated use when intolerance of any of the components of the drug, as well as diabetes, arrhythmia, various blood diseases, violations of kidney and liver, prostate adenoma, pancreatitis. It is not used simultaneously with MAO inhibitors, patients younger than 12 years, during pregnancy and lactation.

Side effects cause allergic reactions, increased blood pressure, nausea, vomiting. In addition, there may be anxiety, insomnia or drowsiness, dizziness, lethargy, confusion. In case of an overdose, a hepatotoxic effect, nausea, vomiting, allergic reactions appears. Treatment is symptomatic.

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Helpex anti-dhl

Especially popular in the season of colds are drugs that effectively and quickly eliminate the symptoms of the disease. Helpex anticoll dx has analgesic and antipyretic effect, as well as anti-inflammatory and anti-allergic effect. Quickly removes the first symptoms of acute respiratory viral infections. After its use, general well-being improves, headaches, sneezing, lacrimation, nasal congestion, coughing occur.

• The medicament contains several active ingredients: paracetamol, cetirizine hydrochloride and phenylephrine hydrochloride. These substances affect the central nervous system and sensitive receptors that cause coughing attacks.
• The medicine is taken from the first days of the disease. Patients over 12 years of age are prescribed 1 capsule up to 4 times a day. Between tablets it is recommended to observe a time interval of 3-4 hours. The course of treatment should not exceed 5-7 days.
• It is not used for hypersensitivity to one of the components, for cardiovascular diseases and hyperthyroidism, during pregnancy and lactation. Contraindicated simultaneous use with tricyclic antidepressants and MAO inhibitors.
• If the medical recommendations are not observed, side effects appear which are manifested by all the systems of the body. Most often, patients complain of decreased / increased blood pressure, tachycardia, urinary retention, various sedative effects, nausea, vomiting and discomfort in the gastrointestinal tract.
• In case of non-compliance with the recommended dosage and exceeding the course of treatment, symptoms of an overdose appear. There are biochemical and clinical signs of liver damage due to the action of paracetamol. Patients pale skin, there is nausea, abdominal pain, metabolic disorders. The remaining components cause drowsiness, increased blood pressure, dizziness. When the above symptoms appear, you need to seek medical help and conduct symptomatic therapy.

Helpex anticold syrup

Very often, various syrups and medicines are used to treat colds accompanied by a cough. Helpex antikold syrup helps to eliminate the first signs of SARS and colds. The composition of the medicament includes several active components that affect the sensory centers of the body and the central nervous system. The drug contains substances such as: phenylephrine hydrochloride, menthol, chlorpheniramine maleate, bromhexine hydrochloride and dextromethorphan hydrobromide. The complex action of the active components allows achieving a stable therapeutic effect in the first days of application.

• The drug is prescribed for the treatment of acute inflammatory infectious diseases, allergic rhinitis, coughing, lacrimation and other signs of upper respiratory tract infection. The syrup is taken orally with water. Patients older than 12 years are prescribed 5-10 ml every 3-4 hours 3 times a day. If the drug is used for children from 6-12 years, I prescribe 5 ml every 4 hours 3 times a day. The course of treatment should not exceed 7 days.
• With individual intolerance to one of the components, the drug is contraindicated to use. It is not used during pregnancy and lactation, as well as for patients younger than 6 years.
• Side effects are manifested as gastrointestinal disorders, mental disorders, dry mucous membranes of the mouth, throat and nose, increased sweating, heart palpitations and others.
• In case of an overdose, there are: increased weakness, sleep disorders, tremor, urinary retention, allergic reactions to the skin, respiratory depression. Treatment is supportive, symptomatic. In case of excessive overdose, seek medical attention and monitor body temperature, respiratory function and blood pressure of the patient.

Pharmacodynamics

The effectiveness of the drug is determined by the action of its constituents after use. Pharmacodynamics Chelpex is represented by several active substances, we consider in more detail their properties.

• Paracetamol

It has antipyretic, analgesic and weak anti-inflammatory properties. The mechanism of action is based on the effect on the center of thermoregulation and inhibition of the synthesis of prostaglandins and inflammatory mediators. Increases the threshold of pain sensitivity.

• Cetirizine hydrochloride

Selective H ₁ -receptor antagonist , a potent antihistamine. It reduces the late allergic reaction, reduces the release of inflammatory mediators. Does not affect other receptors and does not cause antiserotonin or anticholinergic effects.

• Phenylephrine hydrochloride

Selective α ₁ -adrenomimetic with vasoconstrictive action. Reduces swelling of the nasal mucosa, improves nasal breathing, reduces the volume of nasal secretion, which facilitates the passage of air.

• Dextromethorphan hydrobromide

Antitussive, increases the sensitivity threshold of the receptors of the cough center to various stimuli. Softens dry non-productive cough and relieves irritation from the respiratory tract.

• Caffeine

Affects the central nervous system, stimulates the cerebral cortex, respiratory and vasomotor centers.

• Chlorpheniramine maleate

Has anti-allergic effect, relieves itching in the nose, sneezing and lacrimation.

• Menthol

Has a calming and analgesic effect. The effectiveness of the substance is due to reflex reactions, which are associated with irritation of nerve endings. This action leads to a decrease in pain.

• Bromhexine hydrochloride

Antitussive, expectorant and mucolytic substance. Stimulates the synthesis of endogenous surfactant, which ensures the stable functioning and protection of alveolar cells. Improves the rheological effect of bronchopulmonary secretion and excretion of sputum.

Pharmacokinetics

After ingestion, all active substances behave differently, creating a therapeutic effect. Pharmacokinetics describes the processes of distribution, metabolism and excretion of active components, consider this in more detail:

• Paracetamol

Quickly absorbed from the digestive tract, the maximum concentration in the blood plasma - 1 hour after use. Binding to blood proteins is insignificant. The half-life is 1-4 hours. Antipyretic effect persists for 6-7 hours, analgesic - about 5 hours. It is excreted by the kidneys, about 5% unchanged.

• Dextromethorphan hydrobromide

Completely absorbed from the digestive tract, metabolized in the liver, excreted by the kidneys in an unchanged form. The elimination half-life is 3-4 hours.

• Caffeine

It is absorbed from the intestine, most of it is oxidized and demethylated. It is excreted by the kidneys, the half-life is 5-10 hours.

• Cetirizine hydrochloride

Quickly absorbed in the digestive tract. Eating does not affect the level of absorption. The maximum concentration in the blood plasma is 30-60 minutes after application. In adults, the half-life is 7-11 hours, in children 6-7. Binding to blood proteins on the blood at 90%.

• Chlorfeniramine

Slowly absorbed in the digestive tract, the maximum concentration occurs after 3-6 hours after ingestion. 70% binds to blood proteins, bioavailability at the level of 25-50%. In the process of distribution through the body, it penetrates the blood-brain barrier. It is excreted by the kidneys within 4-6 hours.

• Phenylephrine

It is characterized by uneven absorption and low bioavailability. It is excreted in the form of metabolites with urine. In the case of acidification of urine, the elimination process is accelerated.

Dosing and administration

The effectiveness of therapy for upper respiratory tract infection depends on the duration of the course of treatment. Dosage and administration of Helpex are based on the form of release of the medicine and the recommendations of the attending physician.

• Helpex Anticold and Helpex Anticold DX are allowed to be used for patients over 12 years old. As a rule, 1 tablet is prescribed up to 4 times a day. Between medication take a time interval of 4 hours. The medicine is taken an hour after eating, squeezed with plenty of liquid. The course of therapy should not exceed 5 days.
• Syrup Helpex Anti-Oxygen is taken orally with water. For patients over 12 years, appoint 5-10 ml 2-3 times a day, and for children 6-12 years, 5 ml 3 times a day.

[5], [6]

Use Helpex during pregnancy

Treatment of catarrhal diseases in expectant mothers is a rather complicated process, as many drugs have a negative effect on fetal development. Use Chelpex during pregnancy is contraindicated.

The ban on the use of medication is explained by the fact that tablets and syrup contain several active substances that affect the body of a woman and a child in different ways. So, paracetamol and phenylephrine penetrate into breast milk, so the drug is not used and during lactation.

Contraindications

When using any medication, consult your doctor. This is due to the fact that all medicines have certain contraindications to the use. Let's consider it on an example of the combined protivoprostudnogo means Helpeks.

Contraindications:

• Individual intolerance of components
• Diabetes
• Arrhythmia
• Arterial hypertension
• Diseases of the circulatory system
• Hyperthyroidism
• Pancreatitis (at the stage of exacerbation)
• Impaired renal and hepatic function
• Adenoma of the prostate (with difficulty urinating)
• Alcoholism
• Thrombosis of peripheral arteries
• Pregnancy and lactemia
• Age of patients under 12 years (tablets)
• Age of patients under 6 years (syrup)
• Simultaneous use of MAO inhibitors.

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Side effects Helpex

If the drug is used without following the recommendations given in the instructions, a number of negative reactions occur. Side effects of the anti-inflammatory analgesic are manifested by such symptoms:

• Hepatic colic
• Nausea
• Vomiting
• Diarrhea / constipation
• Decreased appetite
• Pain in the epigastric region
• Anemia
• Skin Allergic Reactions
• Thrombocytopenia
• Aseptic pyuria
• Insomnia
• Anxiety
• Dizziness
• Interstitial glomerulonephritis
• High blood pressure
• Confusion of consciousness.

[3], [4]

Overdose

Since the cold remedy Helpex is multicomponent, the effects of overdose are based on the mechanism of action of all its active substances.

• Paracetamol causes the development of a hepatotoxic effect. After 24-72 hours, symptoms of hepatic injury are observed. The patient suffers from vomiting, nausea, pain in the abdomen, pallor of the skin.
• Caffeine provokes attacks of nausea, headaches, anxiety, limb tremors, palpitations, vomiting and confusion.
• Phenylephrine causes an increase in blood pressure, ventricular ekstrasistoliyu, a sense of heaviness in the head and limbs, paroxysms.
• Chlorpheniramine in case of an overdose provokes depression / excitation of consciousness, convulsive syndrome. In rare cases, the appearance of atropine-like symptoms is noted.
• Cetirizine - in adult patients causes drowsiness, and children have arousal, which quickly gives way to drowsiness.

To eliminate the above symptoms it is recommended to carry out symptomatic therapy. During the first hour, it is advisable to wash the stomach and take absorbents. During the first day after an overdose, the administration of N-acetylcysteine.

Interactions with other drugs

Treatment of ARVI and colds requires an integrated approach, so very often several means are used simultaneously. Interaction with other drugs is possible with appropriate indications of the doctor.

• Paracetamol comes into contact with anticoagulants and anticonvulsants. Its antipyretic activity decreases when used with barbiturates.
• Caffeine reduces the effect of sleeping pills and narcotics. Its suction rate decreases due to colestyramine and is increased by metoclopramide.
• When using phenylephrine with MAO inhibitors and sympathomimetic amines, blood pressure rises.
• Chlorpheniramine does not work concomitantly with CNS suppressant drugs (MAO inhibitors, barbiturates, tricyclic antidepressants, tranquilizers), calcium chloride, norepinephrine and kanamycin sulfate.

[7], [8]

Storage conditions

The effectiveness of the therapeutic effect of the drug depends on the conditions of its storage. All forms of the Helplex release must be stored in a dry place, protected from sunlight and inaccessible to children. The storage temperature should not exceed 20-25 ° C. It is recommended to keep the medicine in its original packaging.

Shelf life

Helpex syrup and tablets have different shelf life. After the first opening of the vial, the syrup is suitable for use for 7 days. Tablets and unopened syrup can be stored for 24 months from the date of production (indicated on the packaging / vial), provided that the storage rules are observed.