Hartmann's solution

Hartman's solution is a medicine that is prescribed for decreased blood circulation volumes, acid-base imbalance disorders in the body, and for a number of other indications. Let's look at the features of this drug, methods of use, dosage, contraindications, and interactions with other medicines.

Hartman's solution, like other medications, is taken only for medical reasons. The drug is administered by drip, in the form of infusions. As a rule, Hartman's solution is used for treatment in hospitals, less often infusions are done at home.

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Indications Hartmann's solution

Indications for the use of Hartman's solution are based on medical indications and doctor's recommendations. The drug is prescribed for:

• Severe dehydration with normal acid-base balance;
• Hypovolemia;
• Mild acidosis;
• To compensate for water and electrolyte deficiencies (due to diarrhea, burns, vomiting, peritonitis and other severe infections);
• To maintain extracellular fluid after surgical intervention or during surgery. In this case, the use of Hartman solution makes it possible to delay blood transfusion;
• For the treatment of significant blood loss, shock and trauma.

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Release form

The drug is available in glass bottles of 500 ml and 1000 ml. The drug contains calcium chloride, sodium lactate solution, potassium chloride, hydrochloric acid, sodium chloride and water for injection.

This form of release of Hartman's solution for infusions is very convenient for drip administration. For use in hospital conditions, Hartman's solution is produced in plastic bottles. This form of release does not require special conditions of transportation and storage, unlike glass bottles of this drug. One package contains 10 bottles of Hartman's solution.

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Pharmacodynamics

Pharmacodynamics of Hartman solution are the active substances of the drug and the processes that occur with them after entering the human body. In terms of its osmolarity and composition, Hartman solution belongs to the extracellular fluid. That is why the drug is used to replace electrolytes and fluid. Another purpose of the drug is to regulate the acid-base balance.

Hartman's solution works much more effectively than sodium chloride infusion solution. The drug provides replacement of the most important cations for the human body in the extracellular fluid - (K ⁺ Na ⁺ Ca ²⁺ ). The active substance of the drug is lactate, metabolized in the body into bicarbonate. Hartman's solution has an alkalizing effect.

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Pharmacokinetics

Pharmacokinetics of Hartman solution is the processes of introduction, distribution, metabolism and excretion of the drug. After internal drip administration, Hartman solution very quickly increases the osmolarity of the blood. The drug does not stay in the blood for a long time, and after 30-40 minutes goes to the tissues. The components of the drug are excreted in the urine.

Hartman's infusion solution has a beneficial effect on the body. The drug is practically not metabolized, so it does not affect the functioning of the body's organ systems. As a rule, the drug is used in inpatient treatment, monitoring the patient's condition at the time of drug administration.

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Dosing and administration

The method of administration and dosage of the drug is prescribed by the attending physician. When using the drug in the form of infusions, the average drip rate should be at the level of 60 drops per minute, up to 2500 ml per day, i.e. 2.5 ml per kg of the patient's weight. If the drug is used in emergency conditions, the rate of administration should be up to 100 drops per minute, and the volume of the drug administered depends on the patient's condition.

Please note that within 24 hours after using Hartman's solution, it is necessary to provide the body with the daily fluid requirement. The volume of fluid must also be replenished during the next two days. This will allow the fluid deficit to be fully replenished within 72 hours.

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Use Hartmann's solution during pregnancy

The use of Hartman solution during pregnancy is not recommended. Hartman solution, like any medications, is not recommended for use during pregnancy. The drug is not recommended for use in early pregnancy, as it can cause a miscarriage. The use of Hartman solution in the last months of pregnancy is a direct threat to premature birth and complications during the birth process.

The use of Hartman's solution during pregnancy is possible only for medical reasons, in cases where the potential benefit to the mother is much more important than the risk to the child. The drug is prohibited for use during lactation, since the active substances of Hartman's drug enter the child's blood with mother's milk.

Contraindications

Contraindications to the use of Hartman solution are based on individual intolerance to the active components of the drug and hypersensitivity to their action. The main contraindications to the use of Hartman solution: hypertonic dehydration, cardiac and renal failure, arterial hypertension, hyperlactacidemia and other diseases.

Hartman's solution is prescribed with special caution in cases of acute dehydration, respiratory failure, hypoporteinemia, and during treatment with corticotropin and glucocorticosteroids.

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Side effects Hartmann's solution

Side effects of Hartman's solution occur due to incorrect dosage of the drug. Side effects may also occur when using the drug in patients who have contraindications. So, the main symptoms of the side effects of Hartman's infusion solution:

• Allergic reactions on the skin;
• Hypervolemia;
• Anxiety;
• Hyperchloremia;
• Thrombophlebitis;
• Overhydration.

If side effects occur, discontinue use of the drug or reduce the dosage. It is mandatory to seek medical help to treat the painful symptoms of side effects.

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Overdose

Overdose of Hartman's solution may occur due to high dosage of the drug or high speed of its administration. In case of overdose, a violation of the balance of water and electrolytes in the body, as well as cardiopulmonary decompensation are possible. In this case, the patient is stopped administering Hartman's solution and symptomatic therapy is carried out.

In particularly severe cases of overdose, patients are prescribed drugs that will negate the effect of Hartman's solution. The process of replenishing fluid is mandatory, that is, maintaining a drinking regime to ensure the normal functioning of the organ system.

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Interactions with other drugs

Interaction of Hartman solution with other drugs is possible only with the permission of a doctor. Thus, with the simultaneous use of non-steroidal anti-inflammatory drugs, estrogens, mineralocorticoids, anabolic hormones, vasodilators and Hartman solution, sodium retention in the body is possible.

When Hartman's solution interacts with angiotensin-converting enzyme inhibitors, potassium preparations and diuretics, hyperkalemia may develop. When combined with cardiac glycosides, the toxicity of the latter drugs increases. If Hartman's solution interacts with salicylates, the alkalinity of urine may increase, as well as the process of drug excretion may slow down.

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Storage conditions

The storage conditions for Hartman's solution are described in the instructions for the drug and are no different from the rules for storing other infusion fluids. The drug must be stored in a dry, dark, cool place out of the reach of children. It is important to maintain the temperature regime - from 15 to 25 ° C.

When storing and transporting Hartman's solution in glass bottles, it is very important to be careful. But the storage conditions of Hartman's solution in plastic bottles require compliance with the temperature regime. Please note that failure to comply with the storage conditions of the drug will lead to the loss of its medicinal properties, and therefore ineffectiveness in the treatment process.

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Shelf life

The shelf life of Hartman's solution is 3 years from the date of manufacture of the drug, which is indicated on the packaging of the drug. Upon expiration of the shelf life, the drug must be disposed of. It is strictly prohibited to use an expired infusion solution. Since the use of a spoiled drug can lead to uncontrolled and irreversible negative health consequences and worsen the patient's condition.

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